A5012097474- Calcium signaling and nucleotide metabolism
- Immune Cell Function and Interaction
- Ion Channels and Receptors
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Sirtuins and Resveratrol in Medicine
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Bioactive Compounds and Antitumor Agents
- Cancer, Stress, Anesthesia, and Immune Response
- Galectins and Cancer Biology
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Thermal Regulation in Medicine
- Adenosine and Purinergic Signaling
- Long-Term Effects of COVID-19
- Plant Stress Responses and Tolerance
University Medical Center Hamburg-Eppendorf
2020-2024
Universität Hamburg
2020-2024
The liver is one of the organs most commonly affected by metastasis. presence metastases has been reported to be responsible for an immunosuppressive microenvironment and diminished immunotherapy efficacy. Herein, we aimed investigate role IL-10 in metastasis determine how its modulation could affect efficacy vivo.
Background & AimsUnregulated activity of interleukin (IL) 22 promotes intestinal tumorigenesis in mice. IL22 binds the antagonist subunit alpha 2 (IL22RA2, also called IL22BP). We studied whether alterations IL22BP contribute to colorectal carcinogenesis humans and mice.MethodsWe obtained tumor nontumor tissues from patients with cancer (CRC) measured levels cytokines by quantitative polymerase chain reaction, flow cytometry, immunohistochemistry. Il22bp messenger RNA colon wild-type,...
During an immune response, T cells migrate from blood vessel walls into inflamed tissues by migrating across the endothelium and through extracellular matrix (ECM). Integrins facilitate cell binding to endothelial ECM proteins. Here, we report that Ca 2+ microdomains observed in absence of receptor (TCR)/CD3 stimulation are initial signaling events triggered adhesion proteins increase sensitivity primary murine activation. Adhesion collagen IV laminin-1 increased number a manner dependent on...
Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate (NAADP) is formed as second messenger within seconds and evokes Ca
The intestine is constantly balancing the maintenance of a homeostatic microbiome and protection host against pathogens such as viruses. Many cytokines mediate protective inflammatory responses in intestine, among them IL-1β. IL-1β proinflammatory cytokine typically activated upon specific danger signals sensed by inflammasome. SARS-CoV-2 capable infecting multiple organs, including intestinal tract. Severe cases COVID-19 were shown to be associated with dysregulated immune response,...
Hepatocellular carcinoma (HCC) ranks among the five most common cancer entities worldwide and leads to hundred-thousands of deaths every year. Despite some groundbreaking therapeutical revelations during last years, overall prognosis remains poor. Although immune system fights malignant transformations with a robust anti-tumor response, certain mediators have also been shown promote development. For example, interleukin (IL)-22 has associated HCC progression worsened in multiple studies....
Abstract IL-6 plays a fundamental role in T cell differentiation and is strictly controlled by surface expression shedding of IL-6R. also acts on other cells that might affect maturation. To study the impact cell-autonomous uncontrolled signaling cells, we generated mice with constitutively active IL-6R gp130 chain (Lgp130) expressed either all (Lgp130 × CD4Cre mice) or inducible CD4+ CD4CreERT2 mice). Lgp130 accumulated activated including TH17 lung, resulting severe inflammation. Tamoxifen...
Antigen recognition by the T-cell receptor induces a cytosolic Ca 2+ signal that is crucial for function. The channel TRPM2 (transient potential cation subfamily M member 2) has been shown to facilitate influx of extracellular through plasma membrane T cells. Therefore, it was suggested involved in activation and differentiation. However, these results are largely derived from vitro studies using lines non-physiologic means activation. Thus, relevance TRPM2-mediated signaling cells remains...
Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca2+ mobilizing agent and its inhibition proved to inhibit T-cell activation. However, impact of NAADP signaling on CD4+ differentiation plasticity inflammation in tissues other than central nervous system remains unclear. In this study, we used an antagonist signaling, trans-Ned 19, study role effector function. Partial blockade naïve T cells vitro promoted Th17 cells. Interestingly, 19 also production IL-10,...