A5071399179- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Hepatitis C virus research
- Adolescent and Pediatric Healthcare
- Liver physiology and pathology
- Immune Response and Inflammation
- Pregnancy and Medication Impact
- IL-33, ST2, and ILC Pathways
- Adenosine and Purinergic Signaling
- CAR-T cell therapy research
University Medical Center Hamburg-Eppendorf
2022-2025
Universität Hamburg
2022-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2023
National University of General San Martín
2023
γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance protection compared to other is unclear. We used a mouse model systemic S. infection associated with high bacterial load and persistence kidney. Infection caused fulminant accumulation Renal acquired tissue residency were maintained numbers during chronic infection. At day 7, up 50% renal produced IL-17A situ large fraction remained + Controlled depletion revealed that restricted replication acute...
Abstract IL-6 plays a fundamental role in T cell differentiation and is strictly controlled by surface expression shedding of IL-6R. also acts on other cells that might affect maturation. To study the impact cell-autonomous uncontrolled signaling cells, we generated mice with constitutively active IL-6R gp130 chain (Lgp130) expressed either all (Lgp130 × CD4Cre mice) or inducible CD4+ CD4CreERT2 mice). Lgp130 accumulated activated including TH17 lung, resulting severe inflammation. Tamoxifen...
Background: The P2X7 ion channel, a key sensor of sterile inflammation, has been implicated as therapeutic target in glomerulonephritis, and P2X7-antagonistic nanobodies can attenuate experimental glomerulonephritis. However, little is known about the expression on renal immune cells. Methods: We used conventional immunofluorescence kidney sections well intraperitoneal injection mice followed by flow cytometry analysis parenchymal T cells RNA-sequencing to elucidate function vascular mouse...