A5053965294- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Tissue Engineering and Regenerative Medicine
- DNA Repair Mechanisms
- Metabolism and Genetic Disorders
- Congenital gastrointestinal and neural anomalies
- Diet and metabolism studies
- Electrospun Nanofibers in Biomedical Applications
- Folate and B Vitamins Research
- Microscopic Colitis
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Gastroesophageal reflux and treatments
- Ion Channels and Receptors
- Xenotransplantation and immune response
- Complementary and Alternative Medicine Studies
- Phytochemistry Medicinal Plant Applications
- Neutropenia and Cancer Infections
- 3D Printing in Biomedical Research
- Infant Health and Development
- Neonatal Respiratory Health Research
- Pathogenesis and Treatment of Hiccups
- Mesenchymal stem cell research
- Cancer Research and Treatments
- Biochemical and Molecular Research
University of Vermont
2001-2014
Vermont Cancer Support Network
2006
University of Vermont Medical Center
2002
Systemic administration of mesenchymal stromal cells (MSCs) suppresses airway inflammation and methacholine-induced hyper-responsiveness (AHR) in mouse models T helper cell (Th) type 2-mediated eosinophilic allergic (AAI); however, the efficacy MSCs severe Th17-mediated neutrophilic AAI has not yet been demonstrated. We assessed MSC effects a model mixed Th2/Th17 produced by mucosal exposure to Aspergillus fumigatus hyphal extract (AHE). Following sensitization oropharyngeal AHE...
Changes in mitochondrial DNA copy number and increases mutations, especially deletions, have been associated with exposure to mutagens aging. Common deletions that are the result of recombination between direct repeats human rat (4,977 4,834, bp, respectively) known increase tissues aged individuals. Previous studies used long-distance PCR Southern blot or quantitative determine frequency deleted DNA. A (TaqMan) assay was developed detect both deletion rat. This methodology allows not only...
Persistent changes in gastrointestinal motility frequently accompany the resolution of colitis, through mechanisms that remain to be determined. Trinitrobenzene sulfonic acid (TNBS) colitis guinea pig decreases rate propulsive motility, causes hyperexcitability AH neurons, and induces synaptic facilitation. The neurons are sensitive cyclooxygenase-2 (COX-2) inhibition. aim this investigation was determine if neurophysiological persist following recovery from colitis. Evaluations...
Changes in mucosal serotonin (5-HT) signaling have been detected a number of functional and inflammatory disorders the gastrointestinal (GI) tract. This study was undertaken to determine whether chronic constipation (CC) is associated with disordered 5-HT evaluate caused by opiate use causes such changes.Human rectal biopsy samples were obtained from healthy volunteers, individuals idiopathic CC, taking medication or without occurrence constipation. EC cells identified immunohistochemistry....
Although patients with malignant disease frequently use dietary supplements, the effects of these agents regard to chemotherapy are unclear. Therefore, authors investigated influence vitamin B12, folate, and nutritional supplements on chemotherapy-induced toxicity.Women breast carcinoma were asked complete a questionnaire that recorded their supplements. Blood samples obtained for assessment serum B12 folate levels before after first cycle weekly blood counts. Toxicity was evaluated by...
The Gastrointestinal Motility Monitor (GIMM; Catamount Research and Development; St. Albans, VT) is an in vitro system that monitors propulsive motility isolated segments of guinea pig distal colon. complete consists a computer, video camera, illuminated organ bath, peristaltic heated water bath circulating pumps, custom GIMM software to record analyze data. Compared with traditional methods monitoring colonic peristalsis, the allows for continuous, quantitative evaluation motility. colon...
Abstract Selective serotonin‐reuptake inhibitors are therapies for psychological and bowel disorders, but produce adverse effects in the non‐targeted system. To determine whether human serotonin‐selective reuptake transporter (SERT) transcripts intestine different from brain, rapid amplification of cDNA ends, primer extension RT‐PCR assays were used to evaluate SERT each region. Potential SLC6A4 gene promoter constructs evaluated with a secreted alkaline phosphatase reporter assay. A novel...
The Gastrointestinal Motility Monitor (GIMM; Catamount Research and Development; St. Albans, VT) is an in vitro system that monitors propulsive motility isolated segments of guinea pig distal colon. complete consists a computer, video camera, illuminated organ bath, peristaltic heated water bath circulating pumps, custom GIMM software to record analyze data. Compared with traditional methods monitoring colonic peristalsis, the allows for continuous, quantitative evaluation motility. colon...