A5101742723- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Traditional Chinese Medicine Studies
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Xenotransplantation and immune response
- Musculoskeletal pain and rehabilitation
- Healthcare and Venom Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Endoplasmic Reticulum Stress and Disease
- Methemoglobinemia and Tumor Lysis Syndrome
- Cerebrovascular and Carotid Artery Diseases
- Lipid metabolism and disorders
- ECG Monitoring and Analysis
- Spine and Intervertebral Disc Pathology
- Neonatal Health and Biochemistry
- Peptidase Inhibition and Analysis
- Medication Adherence and Compliance
- Pharmacy and Medical Practices
- Oral health in cancer treatment
Yangzhou University
2021-2024
University of Kansas Medical Center
2011-2023
University of Vermont
2011-2022
Central South University
2021
The First People's Hospital of Zhaoqing
2011-2021
Wuhan Union Hospital
2021
Xiangya Hospital Central South University
2021
Haikou City People's Hospital
2020
The Fourth People's Hospital
2020
Zoucheng People's Hospital
2015
Recellularization of whole decellularized lung scaffolds provides a novel approach for generating functional tissue ex vivo subsequent clinical transplantation. To explore the potential utility stem and progenitor cells in this model, we investigated recellularization mouse lungs after intratracheal inoculation bone marrow-derived mesenchymal stromal (MSCs). The maintained structural features native lungs, including intact vasculature, ability to undergo ventilation, an extracellular matrix...
Several different detergent-based methods are currently being explored for de-cellularizing whole lungs subsequent use as three-dimensional scaffolds ex vivo lung tissue generation. However, it is not yet clear which of these may provide a scaffold that best supports re-cellularization and generation functional tissue. Notably, the detergents used de-cellularization activate matrix metalloproteinases can potentially degrade extracellular (ECM) proteins important binding growth cells...
Hepatitis C virus (HCV) replication complex resides in detergent-insoluble subcellular domains or lipid rafts. We used two proteomics approaches to characterize the protein content of rafts isolated from Huh7 cells and its modification upon HCV replication. Using two-dimensional electrophoresis mass spectrometry, we identified approximately 100 spots rafts; among them, 39 were reproducibly modified replicon cell lines as compared with control lines. also stable isotope labeling by amino...
A novel potential approach for lung transplantation could be to utilize xenogeneic decellularized pig scaffolds that are recellularized with human cells. However, tissues express several immunogenic proteins, notably galactosylated cell surface glycoproteins resulting from alpha 1,3 galactosyltransferase (α-gal) activity, conceivably prevent effective use. Use of lungs α-gal knock out (α-gal KO) pigs presents a alternative and thus comparative de- recellularization wild-type KO was...
Abstract Background Studies in animals showed that PCSK9 is involved HDL metabolism. We investigated the molecular mechanism by which regulates cholesterol concentration and also whether Pcsk9 inactivation might affect efflux capacity of serum atherosclerotic fatty streak volume. Methods Mass spectrometry western blot were used to analyze level apolipoprotein E (APOE) A1 (APOA1). A mouse model overexpressing human LDLR was test effect high levels liver on APOE-containing subfractions....
Lumbar intervertebral disc degeneration (IDD) is a common clinical pathology and has become focus for research in recent years. Matrix metalloproteinases (MMPs) are enzymes responsible the degradation of almost all extracellular matrix proteins (ECM). The over-expression MMPs or tissue inhibitors (TIMPs) may disrupt dynamic balance ECM. Therefore, current study, expression levels MMP-1 TIMP-1 lumbar IDD patients were evaluated an attempt to elucidate their role pathogenesis progression. In...
To evaluate the role of Tp-e and (Tp-e)/QT ratio in differentiating benign ventricular premature complex (VPC) malignant polymorphic tachycardia (PVT).From January 2017 to December 2017, patients with documented (PVT) or fibrillation (VF) were consecutive included classified as PVT/VF group. Sixty age- sex-matched healthy individuals recruited comparative control subdivided into non-VPC VPC Clinical characteristics Tp-e/QT between three groups compared.Tp-e significantly higher group...
NADH-cytochrome b5 oxidoreductase (Ncb5or) in endoplasmic reticulum (ER) is involved fatty acid metabolism, and Ncb5or(-/-) mice fed standard chow (SC) are insulin-sensitive but weigh less than wild type (WT) littermates. develop hyperglycemia at about age 7 weeks due to β-cell dysfunction loss associated with saturated accumulation manifestations of ER oxidative stress. Here we report that when born heterozygous mothers a high fat (HF) diet continue ingest HF, they as much SC-fed WT 5...
Allogeneic lung transplant is limited both by the shortage of available donor lungs and lack suitable long-term assist devices to bridge patients transplantation. Avian have different structure mechanics resulting in more efficient gas exchange than mammalian lungs. Decellularized avian lungs, recellularized with human cells, could therefore provide a powerful novel unit for potential use pulmonary therapeutics. To initially assess this small large models, chicken (Gallus gallus domesticus)...
Effective screening for colorectal cancer (CRC) enables earlier diagnosis and intervention to improve patient survival. In this study, we prospectively conducted a blood-based CRC program community residents in Hanjiang District, Yangzhou City, evaluated the efficacy of multi-locus DNA methylation assay (ColonAiQ). The ColonAiQ-positive rate colonoscopy participation population, detection intestinal lesions, positive predictive value (PPV) advanced adenoma (AA) were calculated, associated...
Ncb5or (NADH cytochrome b5 oxidoreductase) is a cytosolic ferric reductase implicated in diabetes and neurological conditions. comprises (b5) (b5R) domains separated by CHORD-Sgt1 (CS) linker domain. redox activity depends on proper interdomain interactions to mediate electron transfer from NADH or NADPH via FAD heme. While full-length human has proven resistant crystallization, we have succeeded obtaining high-resolution atomic structures of the domain construct containing CS b5R (CS/b5R)....
To analyze the correlation between coronary heart disease and possible risk factors such as age, gender, hypertension, dyslipidemia, smoking, diabetes, uric acid plasma fibrinogen, to screen main of in elderly evaluate intervention status elderly. In unchangeable factors, age is still factor disease; terms onset female later than that male, but complications mortality rate are higher more male. The first level prevention needs doctors patients establish a mutual trust relationship, actively...
To determine the association between glycosylated hemoglobin (HbA1c) and ambulatory blood pressure or heart rate in hypertensive patients.
Chronic obstructive pulmonary disease (COPD) is the 3rd leading cause of death in US and primarily triggered susceptible individuals by chronic cigarette smoke (CS) exposure. Protease/antiprotease imbalances COPD leads to destruction lung matrix. Therapies targeting this imbalance have not yet provided a cure. Mass spectrometry (MS) has been used analyze proteome healthy lungs, but extracellular matrix (ECM) bound proteins (i.e. matrisome (MAT) are difficult detect thus underrepresented....
Abstract Objective To evaluate the presence of Brugada electrocardiogram (ECG) pattern, clinical characteristics, treatment, and long‐term prognosis syndrome in southern Chinese population. Methods This prospective study consisted a consecutive series patients with diagnostic coved type I ECG pattern at baseline between January 2007 February 2020. Histories symptoms including ventricular tachycardia (VT)/ventricular fibrillation (VF) episode, syncope, family history Syndrome (BrS) or...
Magnoliae Officinalis Cortex, a common Chinese medicinal in clinic, should undergo sweating process producing area according to Pharmacopoeia, which affects its genuineness and quality. In light of the concept research mode quality marker(Q-marker) for decoction pieces, active components Cortex pieces altered significantly before after were identified this study. The main pharmacodynamic material basis was clarified by pharmacodynamic, pharmacokinetic drug property research, followed...
Objective The study sought to compare the effect of different proton pump inhibitors (PPI) on antiplatelet efficacy clopidogrel in patients with non-ST segment elevation acute coronary syndrome (NSTEACS). Methods A prospective, randomized clinical trial was studied. One hundred and forty-five NSTEACS after drug eluting stent implantation were recruited study. Patients assigned into group A B randomly, given standard medical therapy (clopidogrel, aspirin, low molecular weight heparin,...
Objective To study tirofiban intravenous injection, coronary artery injection of the two different methods in acute ST segment elevation myocardial infarction, application emergency PCI. Methods Patients underwent PCI with infarction as research subjects, a total 108 cases, patients were randomly divided into observation group and control group, 54 each group.In first dose was injected artery.The treated by injection.The results groups compared. Results Before treatment, TIMI...