A5046551755- Gut microbiota and health
- Diet and metabolism studies
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Sleep and related disorders
- Nutritional Studies and Diet
- Healthcare professionals’ stress and burnout
- Obesity, Physical Activity, Diet
- Metabolomics and Mass Spectrometry Studies
- Oral microbiology and periodontitis research
- Clostridium difficile and Clostridium perfringens research
- Health Sciences Research and Education
- Health, psychology, and well-being
- Sleep and Wakefulness Research
- Genomics and Phylogenetic Studies
- Nutrition and Health in Aging
- Dietary Effects on Health
- Food Security and Health in Diverse Populations
- Adipokines, Inflammation, and Metabolic Diseases
- Health disparities and outcomes
- Nutrition, Genetics, and Disease
- Nursing Diagnosis and Documentation
- Zoonotic diseases and public health
- Nutrition, Health and Food Behavior
- Health, Environment, Cognitive Aging
National Institutes of Health Clinical Center
2020-2025
National Institutes of Health
2020-2025
Columbia University
2023
University of Illinois Chicago
2018-2022
National Academies of Sciences, Engineering, and Medicine
2021
National Institute of Nursing Research
2020
Rockefeller University
2020
National Institutes of Health
2020
Jesse Brown VA Medical Center
2018
The gut microbiota, via the production of metabolites entering circulation, plays a role in blood pressure regulation. Blood is also affected by characteristics sleep. To date, no studies have examined relationships among microbiota/metabolites, pressure, and We hypothesized that fragmented sleep associated with elevated mean arterial an altered dysbiotic microbial community, changes fecal metabolites. In our model system, rats were randomized to 8 h fragmentation during rest phase (light...
Humans are inextricably linked to each other and our natural world, microorganisms lie at the nexus of those interactions. Microorganisms form genetically flexible, taxonomically diverse, biochemically rich communities, i.e., microbiomes that integral health development macroorganisms, societies, ecosystems.
Microbiome research relies on next-generation sequencing and downstream data analysis workflows. Several manufacturers have introduced multi-amplicon kits for microbiome characterization, improving speciation, but present unique challenges analysis. The goal of this methodology study was to develop two pipelines specific mixed-orientation reads from multi-hypervariable (V) region amplicons. A secondary aim assess agreement with expected abundance, considering database variable region. Mock...
Background/Objectives: Food-insecure individuals are at risk for poor health outcomes, including substandard sleep health. A possible association of food insecurity with regularity has not been explored, and factors contributing to the relationship between well understood. This cross-sectional study explored identified specific nutrients that mediated association. Methods: used dietary intake, interview, physical examination, actigraphy, laboratory data from NHANES 2011–2014 assess...
Abstract Shotgun metagenomic sequencing comprehensively samples the DNA of a microbial sample. Choosing best bioinformatics processing package can be daunting due to wide variety tools available. Here, we assessed publicly available shotgun metagenomics packages/pipelines including bioBakery, Just Microbiology System (JAMS), Whole metaGenome Sequence Assembly V2 (WGSA2), and Woltka using 19 mock community set five constructed pathogenic gut microbiome samples. Also included is workflow for...
Nurse scientists play an important role in studying complex relationships among human genetics, environmental factors, and the microbiome, all of which can contribute to health disease. Therefore, it is essential that they have tools necessary execute a successful microbiome research study. The purpose this article highlight methodological factors for nurse consider when designing In addition considering influence host-associated microbiomes (i.e., microorganisms associated with organisms...
Background Plausible phenotype mechanisms following bariatric surgery include changes in neural and gastrointestinal physiology. This pilot study aims to investigate individual combined neurologic, gut microbiome, plasma hormone pre- versus post-vertical sleeve gastrectomy (VSG), Roux-en-Y gastric bypass (RYGB), medical weight loss (MWL). We hypothesized post-weight would be associated with central reward system brain connectivity, differences postprandial responses, increased microbiome...
Current methods of sleep research in rodents involve invasive surgical procedures EEG and EMG electrodes implantation. Recently, a new method measuring sleep, PiezoSleep, has been validated against implanted mice rats. PiezoSleep uses piezoelectric film transducer to detect the rodent's movements respiration employs an algorithm automatically score sleep. Here, we validate scoring versus EEG/EMG rats.Adult male Brown Norway Wistar Kyoto rats were with bilateral stainless-steel screws into...
Introduction The consumption of probiotics may influence children’s gut microbiome and metabolome, which reflect shifts in microbial diversity composition metabolism. These potential changes might have a beneficial impact on health. However, there is lack evidence investigating the effect metabolome children. We aimed to examine two ( Streptococcus thermophilus Lactobacillus delbrueckii ; S2) vs. three (S2 + Bifidobacterium animalis subsp . lactis strain BB-12) strain-supplemented yogurt....
As a risk factor for conditions related to the microbiome, understanding role of SVI on microbiome diversity may assist in identifying public health implications research. Here we found, using sub-sample Human Microbiome Project phase 1 cohort, that was linked across body sites and influence race/ethnicity-based differences diversity. Our findings, build current knowledge regarding human geography research, suggest measures geographic social vulnerability be considered as additional...
The notion that genetics, through natural selection, determines innate traits has led to much debate and divergence of thought on the impact human phenotype. purpose this synthesis was examine how theory informs genetic research understanding lens Martha Rogers' unitary beings can offer a contemporary view inform epigenetic research. We also propose new conceptual model for philosophical, theoretical, literatures were examined synthesis. have merged philosophical phenomena from with into...
Abstract Introduction Connections between sleep and cardiovascular risk health are reported in adults. The regularity index (SRI), a measure of day-to-day variability sleep-wake times, has been shown to be associated with older connection SRI health, the American Heart Association (AHA) derived concept positive promotion across lifespan, yet reported. aim this work is investigate associations health. Methods Using National Health Nutrition Examination Survey (NHANES) 2011-2014 data US adults...
Abstract Introduction Colorectal cancer is one of the most common cancers worldwide. Patients with this disease may experience gut dysbiosis and various psychoneurological symptoms (PNS) including, sleep disturbance, psychological distress, pain. Family caregivers involved in managing their day-to-day needs also similar PNS. This study aimed to explore associations between characteristics microbiome patient-caregiver dyads stratified by presence or absence Methods colorectal sleep-partner...
Alcohol use disorder (AUD) is commonly associated with distressing psychological symptoms. Pathologic changes AUD have been described in both the gut microbiome and brain, but mechanisms underlying gut-brain signaling individuals are unknown. This study examined associations among microbiome, brain morphometry, clinical symptoms treatment-seeking AUD.