A5007837273- Gut microbiota and health
- Diet and metabolism studies
- Single-cell and spatial transcriptomics
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Craniofacial Disorders and Treatments
- Agriculture Sustainability and Environmental Impact
- Human-Animal Interaction Studies
- COVID-19 Impact on Reproduction
- Metabolomics and Mass Spectrometry Studies
- Mycobacterium research and diagnosis
- Intergenerational Family Dynamics and Caregiving
- Cancer Immunotherapy and Biomarkers
- Congenital heart defects research
- Reproductive System and Pregnancy
- Primate Behavior and Ecology
- Microscopic Colitis
- Immune Cell Function and Interaction
- Nutritional Studies and Diet
Northwestern University
2023-2025
Wellcome/MRC Cambridge Stem Cell Institute
2024
University of Cambridge
2024
Wellcome Sanger Institute
2024
Harvard University
2022
Human embryonic bone and joint formation is determined by coordinated differentiation of progenitors in the nascent skeleton. The cell states, epigenetic processes key regulatory factors that underlie lineage commitment these cells remain elusive. Here we applied paired transcriptional profiling approximately 336,000 nucleus droplets spatial transcriptomics to establish a multi-omic atlas human cranium development between 5 11 weeks after conception. Using combined modelling data,...
Abstract The gastrointestinal tract is a multi-organ system crucial for efficient nutrient uptake and barrier immunity. Advances in genomics surge diseases 1,2 has fuelled efforts to catalogue cells constituting tissues health disease 3 . Here we present systematic integration of 25 single-cell RNA sequencing datasets spanning the entire healthy development adulthood. We uniformly processed 385 samples from 189 controls using newly developed automated quality control approach (scAutoQC),...
Abstract Industrialized diets that incorporate processed foods and are often high in simple sugars fats low fiber have myriad health impacts, many of which may operate via impacts on the gut microbiota. Examining how these affect microbiota can be challenging given lab animal models experience altered environmental contexts, human studies include a suite co-varying cultural factors likely to shape alongside diet. To complement approaches, we compare microbiomes wild populations olive baboons...
ABSTRACT The primary goal of captive primate management is to ensure optimal health and welfare the animals in our care. Given that gut microbiome interacts closely with host metabolism, immunity, even cognition, it represents a potentially powerful tool for identifying subtle changes status across range body systems simultaneously. However, thus far, has not been widely tested or implemented as monitoring tool. In this study, we used longitudinal sampling newly arrived chimpanzees at Chimp...
The gastrointestinal (GI) tract consists of connected organs, from the oral cavity to rectum, which function ensure efficient nutrient uptake and barrier immunity. Diseases GI affect millions worldwide as such there are now over 25 published single cell RNA-sequencing (scRNAseq) datasets surveying tract, profiling specific anatomical regions, lineages, ages diseases. To consolidate these efforts, we harmonised integrated scRNAseq across whole developing adult human tissues, well newly...
Abstract A central goal of biological anthropology is connecting environmental variation to differences in host physiology, biology, health, and evolution. The microbiome represents a valuable pathway for studying how environments impacts health outcomes. While there are many resources learning about methods related sample collection, laboratory analyses, genetic sequencing, fewer dedicated helping researchers navigate the dense portfolio bioinformatics statistical approaches analyzing data....