A5008896114- Gut microbiota and health
- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Microbial Metabolites in Food Biotechnology
- Food composition and properties
- Bioinformatics and Genomic Networks
- Environmental DNA in Biodiversity Studies
- Vestibular and auditory disorders
- Neurobiology and Insect Physiology Research
- Insect symbiosis and bacterial influences
- Silk-based biomaterials and applications
- Hearing Loss and Rehabilitation
- Animal and Plant Science Education
- Biofuel production and bioconversion
- Diet, Metabolism, and Disease
- Developmental Biology and Gene Regulation
- Probiotics and Fermented Foods
- Childhood Cancer Survivors' Quality of Life
- Amino Acid Enzymes and Metabolism
- Hematopoietic Stem Cell Transplantation
- CRISPR and Genetic Engineering
- Hearing, Cochlea, Tinnitus, Genetics
Universitätsklinikum Erlangen
2024
Duke University
2022-2024
Fox Chase Cancer Center
2015-2023
Immersion (United States)
2023
University of Virginia
2021-2022
University of the Virgin Islands
2019
Previous studies suggest that gut microbiome disruption induced by chemotherapy, dietary deficiencies, and/or antibiotics are associated with increased incidence of acute graft-versus-host disease (aGVHD) following hematopoietic stem cell transplantation (HSCT). In a murine model antibiotic-induced disruption, Holmes and colleagues show oral administration galactooligosaccharides (GOS) as prebiotic attenuates lethal aGVHD, highlighting the crosstalk between diet microbiota. Their data...
Abstract In many tissues, the presence of stem cells is inferred by capacity tissue to maintain homeostasis and undergo repair after injury. Isolation self-renewing with ability generate full array within a given strongly supports this idea, but identification genetic manipulation individual their niche remain challenge. Here we present novel methods for marking genetically altering epithelial follicle (FSCs) Drosophila ovary. Using these new tools, define sequential multistep process that...
Fructans are commonly used as dietary fibre supplements for their ability to promote the growth of beneficial gut microbes. However, fructan consumption has been associated with various dosage-dependent side effects. We characterised effects in an exploratory analysis a randomised trial healthy adults (
Genome-scale metabolic network reconstructions (GENREs) are valuable tools for understanding microbial metabolism. The process of automatically generating GENREs includes identifying reactions supported by sufficient genomic evidence to generate a draft network. GENRE is then gapfilled with additional in order recapitulate specific growth phenotypes as indicated associated experimental data. Previous methods have implemented absolute mapping thresholds the included GENREs; however, there...
Tinnitus is a symptom often associated with hearing loss (HL) and in many cases more burdening to the individual than HL itself. Many approaches have been made explain development chronification of phantom percept as well different treatment strategies lower tinnitus related burden. In studies, variance data high therefore interpretation specific might be difficult. With this retrospective study, we attempt part by investigating specifically effects non-auditory comorbidity categories on...
<title>Abstract</title> Tinnitus is a symptom often associated with hearing loss (HL) and in many cases more burdening to the individual than HL itself. Many approaches have been made explain development chronification of phantom percept as well different treatment strategies lower tinnitus related burden. In studies, variance data high therefore interpretation specific might be difficult. With this retrospective study, we attempt part by investigating specifically effects non-auditory...
Abstract Members of the Lactobacillus genus are frequently utilized in probiotic industry with many species conferring demonstrated health benefits; however, these effects largely strain-dependent. We designed a method called PROTEAN (Probabilistic Reconstruction Of constituent Anabolic Networks) to computationally analyze genomic annotations and predicted metabolic production capabilities 144 strains across 16 isolated from human intestinal, oral, vaginal body sites. Using we conducted...
Abstract Genome-scale metabolic network reconstructions (GENREs) are valuable tools for understanding microbial community metabolism. The process of automatically generating GENREs includes identifying reactions supported by sufficient genomic evidence to generate a draft network. GENRE is then gapfilled with additional in order recapitulate specific growth phenotypes as indicated associated experimental data. Previous methods have implemented absolute mapping thresholds the included GENREs;...