A5087708158- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Bacteriophages and microbial interactions
- Gut microbiota and health
- T-cell and B-cell Immunology
- Bacterial Genetics and Biotechnology
- Bacillus and Francisella bacterial research
- Antimicrobial Peptides and Activities
- Vector-borne infectious diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Research and Splicing
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Mosquito-borne diseases and control
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- Probiotics and Fermented Foods
- interferon and immune responses
University of Washington
2020-2023
University of California, San Francisco
2020-2022
University of California, Berkeley
2016-2019
University of Amsterdam
2013
University of North Carolina at Chapel Hill
2012
Background Increasing evidence supports the central role of Paneth cells in maintaining intestinal host-microbial homeostasis. However, direct impact host genotype on cell function remains unclear. Here, we characterize key differences and microbial composition two widely utilized, genetically distinct mouse strains (C57BL/6 129/SvEv). In doing so, demonstrate critical influences activity enteric microbiota. Methodology Principal Findings numbers were determined by flow cytometry....
B-1a cells play an important role in mediating tissue homeostasis and protecting against infections. They are the main producers of ‘natural’ IgM, spontaneously secreted serum antibodies predominately reactive to self antigens, like phosphatidylcholine (PtC), or antigens expressed by intestinal microbiota. The mechanisms that regulate immunoglobulin (Ig) repertoire their antibody secretion remain poorly understood. Here, we use a novel reporter mouse demonstrate production self-...
In allergic asthma, allergen inhalation leads to local Th2 cell activation and peribronchial inflammation. However, the mechanisms for antigen capture presentation remain unclear. By two-photon microscopy of mouse lung, we established that soluble antigens in bronchial airway lumen were efficiently captured presented by a population CD11c + interstitial macrophages with high CX3CR1-GFP MHC class II expression. We refer these cells as Bronchus-Associated Macrophages (BAMs) based on their...
Glutathione (GSH) is an abundant metabolite within eukaryotic cells that can act as a signal, nutrient source, or serve in redox capacity for intracellular bacterial pathogens. For Francisella, GSH thought to be critical vivo source of cysteine; however, the cellular pathways permitting utilization by Francisella differ between strains and have remained poorly understood. Using genetic screening, we discovered unique pathway Francisella. Whereas prior work suggested catabolism initiates...
Abstract In allergic asthma, allergen inhalation leads to local Th2 cell activation and peribronchial inflammation. However, the mechanisms for antigen capture presentation remain unclear. By two-photon microscopy, we established that soluble antigens in bronchial airway lumen were efficiently captured presented by a population of CD11c + interstitial macrophages with high CX3CR1-GFP MHC class II expression. We refer these cells as Bronchus-Associated Macrophages (BAMs) based on their...
Abstract Glutathione (GSH) is an abundant metabolite that can act as a signal, nutrient source, or serve in redox capacity for intracellular pathogens. For Francisella, GSH thought to be critical vivo source of cysteine; however, the cellular pathways permitting utilization by Francisella differ between strains and have remained poorly understood. Using genetic screening, we discovered unique pathway spp. Whereas prior work suggested catabolism initiates periplasm, define consists major...