A5056655805- Immune Response and Inflammation
- Immune Cell Function and Interaction
- interferon and immune responses
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- Immune cells in cancer
- Mesenchymal stem cell research
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Circular RNAs in diseases
University of California, Berkeley
2009-2017
University of California, Los Angeles
2008
The innate immune system responds to unique molecular signatures that are widely conserved among microbes but not normally present in host cells. Compounds stimulate pathways may be valuable the design of novel adjuvants, vaccines, and other immunotherapeutics. cyclic dinucleotide cyclic-di–guanosine monophosphate (c-di-GMP) is a recently appreciated second messenger plays critical regulatory roles many species bacteria produced by eukaryotic In vivo vitro studies have previously suggested...
Diversity-generating retroelements (DGRs) recognize novel ligands through massive protein sequence variation, a property shared uniquely with the adaptive immune response. Little is known about how recognition achieved by DGR variable proteins. Here, we present structure of Bordetella bacteriophage major tropism determinant (Mtd) bound to receptor pertactin, revealing remarkable adaptability in static binding sites Mtd. Despite large dissimilarities ligand mode, principles underlying...
Abstract Neutrophils are generally the first immune cells recruited during development of sterile or microbial inflammation. As these express many innate receptors with potential to directly recognize endogenous signals, we set out assess whether their functions locally influenced by signals present at onset Using a mouse model peritonitis, demonstrate that neutrophils elicited in presence C-type lectin receptor ligands have an increased ability produce cytokines, chemokines, and lipid...