A5055053640- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Alzheimer's disease research and treatments
- Erythrocyte Function and Pathophysiology
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
National Institute of Chemistry
2021-2023
University of Ljubljana
2022-2023
Reactive oxygen species (ROS) regulate the activities of inflammasomes, which are innate immune signaling organelles that induce pyroptosis. The mechanisms by ROS control inflammasome unclear and may be multifaceted. Herein, we report protein gasdermin D (GSDMD), forms membrane pores upon cleavage inflammasome-associated caspases, is a direct target ROS. Exogenous endogenous sources ROS, ROS-inducing stimuli prime cells for pyroptosis induction, promote oligomerization cleaved GSDMD, leading...
Abstract Reactive oxygen species (ROS) affect inflammation and immunity in a multitude of ways, particular the context signaling pathways that determine cell fate. Inflammasomes are multiprotein cytoplasmic complexes whose pyroptosis-inducing activities controlled by ROS. Our knowledge how ROS mediates inflammasome is largely based on studies initiating events these pathways. Herein, we show controls terminal pyroptosis We found oxidizes protein gasdermin D (GSDMD) promotes its assembly into...