A5048492696- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Congenital Ear and Nasal Anomalies
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Respiratory viral infections research
- interferon and immune responses
- Asthma and respiratory diseases
- Diabetes and associated disorders
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Viral Infections and Outbreaks Research
- Genomic variations and chromosomal abnormalities
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Genomics and Rare Diseases
- Biochemical and Molecular Research
- RNA Research and Splicing
- Inflammatory mediators and NSAID effects
EMBL Australia
2017-2024
Boston Children's Hospital
2022
Harvard University
2022
UNSW Sydney
2006-2017
Broad Institute
2009-2011
Cooperative Trials Group for Neuro-Oncology
2006-2008
Garvan Institute of Medical Research
2005-2008
St Vincent's Clinic
2006
The adipocyte fatty acid-binding protein aP2 regulates systemic glucose and lipid metabolism. We report that aP2, in addition to being abundantly expressed by adipocytes, is also human airway epithelial cells shows a striking upregulation following stimulation of with the Th2 cytokines IL-4 IL-13. Regulation mRNA expression was highly dependent on STAT6, transcription factor major regulatory role allergic inflammation. examined aP2-deficient mice model inflammation found infiltration...
B cell-activating factor belonging to the TNF family (BAFF; BLyS) is a critical regulator of cell maturation and survival, its overexpression in BAFF transgenic (Tg) mice results development autoimmune disorders. also affects T function through binding one receptors, BAFF-R. Using Tg mice, we examined typical Th1-mediated response, cutaneous delayed-type hypersensitivity reaction, found much greater degree paw swelling inflammation than control mice. Importantly, scores correlated directly...
Abstract The fatty acid-binding protein (FABP) family consists of a number conserved cytoplasmic proteins with roles in intracellular lipid transport, storage, and metabolism. Examination comprehensive leukocyte gene expression database revealed strong the adipocyte FABP aP2 human monocyte-derived dendritic cells (DCs). We isolated bone marrow-derived DC from aP2-deficient mice, showed that cytokines including IL-12 TNF was significantly impaired these cells. Degradation IκBα also DCs,...
Type 1 diabetes (T1D) is an autoimmune disease that shows familial aggregation in humans and likely has genetic determinants. Disease linkage studies have revealed many susceptibility loci for T1D mice humans. The mouse locus insulin-dependent 3 (Idd3), which a homologous interval humans, encodes cytokine genes Il2 Il21 regulates other diseases; however, the cellular molecular mechanisms of this regulation are still being elucidated. Here we show T cells from NOD produce more less exhibit...
Newborn screening (NBS) assays for spinal muscular atrophy (SMA) typically use a polymerase chain reaction (PCR) based assay to identify individuals with homozygous deletion in exon 7 of the SMN1 gene. Due high DNA sequence homology between and SMN2, it has previously been difficult accurately bioinformatically map short reads from next-generation sequencing (NGS) SMN1, resulting low analytical performance preventing NGS being used SMA screening. Advances bioinformatics have allowed be...
RNA interference (RNAi) provides a powerful way to investigate the role of genes in disease pathogenesis and modulate gene expression treat disease. In 2018, FDA approved patisiran, first RNAi-based drug, hence paving for novel class RNAi therapeutics. Harnessing inhibit vaginal HIV transmission requires effective silencing immune cells, which remains difficult. Knockdown accessible mucosal tissues may be easier than systemic silencing. Vaginally applied cholesterol-conjugated small...
Abstract Background Cystic Fibrosis (CF) is one of the most prevalent autosomal recessive inherited disease in Caucasians. Rates CF were thought to be negligible non-Caucasians but growing epidemiological evidence shows more common Indian, African, Hispanic, Asian, and other ethnic groups than previously thought. Almost all second-tier molecular diagnostic tools currently used confirm diagnosis consist panels CF-causing DNA variants However non-Caucasian individuals with often have a...
European and Australian guidelines for cystic fibrosis (CF) reproductive carrier screening recommend testing a small number of high frequency CF causing variants, rather than comprehensive CFTR sequencing. The study objective was to determine variant detection rates commercially available targeted tests in Australia.Next-generation DNA sequencing the gene performed on 2552 individuals from whole population sample identify variants. two tests, which target 50 or 175 this were calculated....