A5103135506- Pancreatic function and diabetes
- Gene expression and cancer classification
- Liver physiology and pathology
- Diabetes Management and Research
- Diabetes and associated disorders
- Genomic variations and chromosomal abnormalities
- CRISPR and Genetic Engineering
- Liver Disease Diagnosis and Treatment
- Head and Neck Cancer Studies
- Colorectal and Anal Carcinomas
- RNA modifications and cancer
- Retinal Development and Disorders
- Cancer Genomics and Diagnostics
- Genetics, Aging, and Longevity in Model Organisms
- Bioinformatics and Genomic Networks
Shanghai Model Organisms (China)
2018-2023
National Taiwan University
2013-2022
Organ homeostasis is orchestrated by time- and spatially restricted cell proliferation. Studies identifying cells with superior proliferative capacities often rely on the lineage tracing of a subset populations, which introduces potential selective bias. In this work, we developed genetic system [proliferation tracer (ProTracer)] incorporating dual recombinases to seamlessly record proliferation events entire populations over time in multiple organs. mouse liver, ProTracer revealed more...
Unraveling cell fate plasticity during tissue homeostasis and repair can reveal actionable insights for stem biology regenerative medicine. In the pancreas, it remains controversial whether lineage transdifferentiation among exocrine cells occur under pathophysiological conditions. Here, to address this question, we used a dual recombinase-mediated genetic system that enables simultaneous tracing of pancreatic acinar ductal using two distinct reporters, avoiding "ectopic" labeling by...
Purpose: The aim of the study was to perform genome-wide characterization Taiwanese breast cancer at molecular level by integrating 2 microarray technologies: comparative genomic hybridization (CGH) for analyzing DNA copy number changes, and gene expression profiles determining transcriptional variations. Concurrent gains losses from same subject across contexts may indicate potential biomarkers endemic cancer. Methods: Fourteen pairs cancerous normal tissue were collected prospectively....
Abstract It is now widely believed that low-frequency variants may play an important role in cancers. In addition, are usually closely related to populations. To identify the disease-associated variants, several projects underway build a reference of genetic variations from different Furthermore, massive tools and databases available compare dynamic gene expression among organs predict functional effects variants. These resources aid roots cancers populations easier. Despite existence...