A5007644722- Chromatin Remodeling and Cancer
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Congenital heart defects research
- Cancer-related Molecular Pathways
- Protein Degradation and Inhibitors
- Cancer Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Cancer Genomics and Diagnostics
- Tumors and Oncological Cases
- Cardiac Fibrosis and Remodeling
- Retinoids in leukemia and cellular processes
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Estrogen and related hormone effects
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Congenital Heart Disease Studies
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Oral and Maxillofacial Pathology
- Advanced Breast Cancer Therapies
- Esophageal Cancer Research and Treatment
- Head and Neck Cancer Studies
- Growth Hormone and Insulin-like Growth Factors
Peter MacCallum Cancer Centre
2016-2025
John Hunter Hospital
2024
The University of Melbourne
2021
Walter and Eliza Hall Institute of Medical Research
2010-2020
The Royal Melbourne Hospital
2011-2020
St John of God Subiaco Hospital
2019
Victor Chang Cardiac Research Institute
2005-2017
Melbourne Health
2013
UNSW Sydney
2006-2010
Keio University
2010
The pulmonary vein is sleeved by myocardium, which a major source of atrial fibrillation and involved in congenital sinus venosus defects. Little known about the cellular origin mechanism formation myocardium. We observed biphasic process myocardium mice. Firstly, myocardial cell population forms de novo at connection atrium. Genetic labeling revealed that cells do not contribute to this population, indicating it differentiation mesenchymal cells. Secondly, these initiate phase rapid...
The sinoatrial node, which resides at the junction of right atrium and superior caval vein, contains specialized myocardial cells that initiate heart beat. Despite this fundamental role in function, embryonic origin mechanisms localized formation node have not been defined. Here we show subsequent to Nkx2-5 –positive tube, bordering inflow tract tube give rise –negative sinus horns. Using genetic models, as myocardium matures, suppresses pacemaker channel gene Hcn4 T-box transcription factor...
The venous pole of the mammalian heart is a structurally and electrically complex region, yet lineage molecular mechanisms underlying its formation have remained largely unexplored. In contrast to classical studies that attribute origin myocardial sinus horns embryonic pole, we find form only after looping by differentiation mesenchymal cells septum transversum region into myocardium. their precursor never express Nkx2–5 , transcription factor critical for development. addition, show do not...
Estrogen-induced progression through G1 phase of the cell cycle is preceded by increased expression G1-phase regulatory proteins c-Myc and cyclin D1. To investigate potential contribution these to estrogen action, we derived clonal MCF-7 breast cancer lines in which or D1 was expressed under control metal-inducible metallothionein promoter. Inducible either sufficient for S-phase entry cells previously arrested pretreatment with ICI 182780, a potent antagonist. not accompanied Cdk4...
The genetic hierarchies guiding lineage specification and morphogenesis of the mammalian embryonic heart are poorly understood. We now show by gene targeting that murine T-box transcription factor Tbx20 plays a central role in these pathways, has important activities both cardiac development adult function. Loss results death embryos at mid-gestation with grossly abnormal morphogenesis. Underlying disturbances was severely compromised transcriptional program,defects molecular pre-pattern,...
The classification of small cell lung cancer (SCLC) into distinct molecular subtypes defined by ASCL1, NEUROD1, POU2F3, or YAP1 (SCLC-A, -N, -P, -Y) expression, paves the way for a personalized treatment approach. However, existence YAP1-expressing SCLC subtype remains controversial.
Estrogen antagonists inhibit cell cycle progression in estrogen-responsive cells, but the molecular mechanisms are not fully defined. Antiestrogen-mediated G0/G1 arrest is associated with decreased cyclin D1 gene expression, inactivation of D1-cyclin dependent kinase (Cdk) 4 complexes, and phosphorylation retinoblastoma protein (pRb). We now show that treatment MCF-7 breast cancer cells pure estrogen antagonist ICI 182780 results inhibition E-Cdk2 activity prior to a decrease G1 S phase...
BRAF and CRAF are critical components of the MAPK signaling pathway which is activated in many cancer types. In approximately 1% melanomas, or through structural arrangements. We describe here a metastatic melanoma with GOLGA4-RAF1 fusion pathogenic variants CTNNB1 CDKN2A. Anti-CTLA4/anti-PD1 combination immunotherapy failed to control tumor progression. absence other actionable patient was administered MEK inhibitor therapy on basis its potential action against RAF1 fusions. This resulted...
Estrogens and insulin/insulin-like growth factor-I (IGF-I) are potent mitogens for breast epithelial cells and, when co-administered, induce synergistic stimulation of cell proliferation. To investigate the molecular basis this effect, a MCF-7 cancer model was established where serum deprivation concurrent treatment with pure estrogen antagonist, ICI 182780, inhibited factor action arrested in G0/G1 phase. Subsequent insulin or IGF-I alone failed to significant S-phase entry. However, these...
Communication between neighboring tissues plays a central role in guiding organ morphogenesis. During heart tube assembly, interactions with the adjacent endoderm control medial movement of cardiomyocytes, process referred to as cardiac fusion. However, molecular underpinnings this endodermal-myocardial relationship remain unclear. Here, we show an essential for platelet-derived growth factor receptor alpha (Pdgfra) directing Mutation pdgfra disrupts assembly both zebrafish and mouse....
The transcription factor GLI1 is a critical effector of the sonic hedgehog pathway. Gene fusions that activate have recently been reported in several tumor types including gastroblastoma, plexiform fibromyxoma, subset pericytomas, and other soft tissue tumors. These tumors arise wide variety anatomical origins variable malignant potentials, morphologies, immunohistochemistry profiles. In this case report, we describe from jejunum with MALAT1-GLI1 gene fusion expressed truncated...