A5004800197- Spinal Cord Injury Research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Trauma Management and Diagnosis
- Trauma and Emergency Care Studies
- Emergency and Acute Care Studies
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Pelvic and Acetabular Injuries
- Nerve Injury and Rehabilitation
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Cardiac Arrest and Resuscitation
- Cancer, Hypoxia, and Metabolism
- Tracheal and airway disorders
- Shoulder Injury and Treatment
- Cardiovascular and Diving-Related Complications
- Estrogen and related hormone effects
- Scoliosis diagnosis and treatment
- Systemic Lupus Erythematosus Research
- Laser Applications in Dentistry and Medicine
- Amyotrophic Lateral Sclerosis Research
- Neurofibromatosis and Schwannoma Cases
Royal North Shore Hospital
2015-2024
University of Southern California
2024
North Shore Hospital
2020-2022
The University of Sydney
2005-2020
Tempus Labs (United States)
2020
Northern Sydney Local Health District
2017
Prince of Wales Hospital
2016
UNSW Sydney
2016
St Vincent's Hospital Sydney
1998
Mater Misericordiae Hospital
1998
Riluzole is a sodium-glutamate antagonist that attenuates neurodegeneration in amyotrophic lateral sclerosis (ALS). It has shown favorable results promoting recovery pre-clinical models of traumatic spinal cord injury (tSCI) and early phase clinical trials. This study aimed to evaluate the efficacy safety riluzole acute cervical tSCI. An international, multi-center, prospective, randomized, double-blinded, placebo-controlled, adaptive, Phase III trial (NCT01597518) was undertaken. Patients...
Background: Interspinous spacers are used in selected patients for the treatment of lumbar spinal stenosis. The uses interspinous devices still debated, with reports significantly higher reoperation rates and unfavourable cost-effectiveness compared to traditional decompression techniques. Methods: Six electronic databases were searched from their date inception December 2015. Relevant studies identified using specific eligibility criteria data was extracted analyzed based on predefined...
Abstract Background Laboratory spinal biomechanical tests using human cadaveric or animal spines have limitations in terms of disease transmission, high sample variability, decay and fatigue during extended testing protocols. Therefore, a synthetic biomimetic spine model may be an acceptable substitute. The goal current study is to evaluate the properties model; also assess mechanical performance lateral plating following interbody fusion. Methods Three L3/4 motion segments were examined...
Background: Immobilization of the cervical spine is a cornerstone spinal injury management. In context suspected injury, patients are immobilized in 'neutral position' based on head and trunk resting flat surface. It hypothesized that increased thoracic kyphosis loss lordosis seen elderly may require alternative immobilization, compared with position'. Methods: To investigate this, an audit pan-scan CT performed consecutive major trauma aged over 65 years was carried out 6-month period....
Retrospective case series.To test validity of subaxial injury classification (SLIC) treatment recommendations.Although SLIC has been tested for reliability, external studies that the its recommendations are lacking.The score was determined by reviewing imaging and clinical records in a consecutive series 185 patients with cervical spine trauma presenting to level 1 spinal referral center. Details including attending surgeon responsible decision, received, surgical approach were...
To describe pre-hospital, emergency department and acute care assessment management practices of senior clinicians for patients with traumatic spinal cord injury (TSCI) across Australia; to clinical practice variation. We used a descriptive, cross-sectional study design survey (greater than 10 years in this field) caring TSCI. The assessment, referral prehospital, department/trauma surgical expert clinicians, early hospital care, diagnostic imaging haemodynamic were surveyed. invited 95...
The present retrospective study was performed to assess the anatomical features of pedicle in isthmic spondylolisthesis and correlate this with degree slip.Twenty-six patients spondylolytic were studied. Relevant patient variables, length, width, height L5 pedicle, product angle between vertebral midline measured. length posterior compartment calculated as angle.With measurements comparable those reported previous publications, found be longer, width body shorter, than published values for...
Introduction Around 300 people sustain a new traumatic spinal cord injury (TSCI) in Australia each year; relatively low incidence with extremely high long-term associated costs. Care standards are inconsistent nationally, lacking consensus across important components of care such as prehospital immobilisation, timing surgery and timeliness transfer to specialist services. This study aims develop ‘expertly defined’ agreed the majority disciplines involved for these patients. Methods analysis...
Abstract Objective Evidence‐based management for patients with acute traumatic spinal cord injury (TSCI) in the ED has a critical impact on long‐term outcomes. Acute hypotension post‐injury may compromise perfusion and extend neurological damage. Published guidelines recommend mean arterial blood pressure (BP) maintenance between 85 90 mmHg 7 days post‐injury; extent to which this is followed Australia unknown. Methods Prospective observational study of ≥16 years TSCI, treated at 48...
Spinal cord injury affects a large number of young individuals with significant cost to affected persons, families and societies both in terms economic non-economic costs. To date, our interventions have been limited prevention, good initial resuscitation, modest pharmacotherapy nursing care. This review examines the role surgery spinal injury. The pathophysiology is reviewed. compelling animal data for early decompression discussed as well evidence improved neurological outcome humans....
Timely treatment is essential for achieving optimal outcomes after traumatic spinal cord injury (TSCI), and expeditious transfer to a specialist unit (SCIU) recommended within 24 h from injury. Previous research in New South Wales (NSW) found only 57% of TSCI patients were admitted SCIU acute post-injury care; 73% transferred We evaluated pre-hospital inter-hospital practices better understand the care pathways impact on patient highlight areas health service pathway that may benefit improvement.
The Morel-Lavallée lesion (MLL) is a closed degloving injury caused by traumatic separation of the subcutaneous tissue from underlying fascia, without break in overlying skin. We present two cases that demonstrate previously unrecognised association MLL with thoracolumbar spine fractures. frequently missed, or its significance overlooked, on initial evaluation. Awareness this should allow tailored strategies to decrease high risk wound complications.
While obesity is associated with an increased risk of complications after total hip arthroplasty (THA) the relationship between body mass index (BMI) and early postoperative has not been fully characterized. This study sought to describe BMI complications, including periprosthetic joint infection (PJI), composite surgical, medical complications. Primary, elective THAs performed from 2016–2021 were identified using Premier Healthcare Database (PHD). The study's primary outcome was diagnosis...