A5086201199- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Brain Metastases and Treatment
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Elbow and Forearm Trauma Treatment
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Hip disorders and treatments
- Spinal Dysraphism and Malformations
- Substance Abuse Treatment and Outcomes
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- Opioid Use Disorder Treatment
- Ocular Oncology and Treatments
- Foot and Ankle Surgery
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Research Studies
- Hormonal Regulation and Hypertension
- Tendon Structure and Treatment
Royal North Shore Hospital
2008-2022
University College London
2011-2022
Epsom and St Helier University Hospitals NHS Trust
2015-2022
North Shore Hospital
2006-2021
Epsom Hospital
2010-2019
Birmingham and Solihull Mental Health NHS Foundation Trust
2018
Royal Surrey County Hospital
2012-2013
Alexandra Hospital
2013
Centre for Cancer Biology
2011
The University of Adelaide
2011
Poor adherence to treatment diminishes its individual and public health benefit. Financial incentives, provided on the condition of attendance, could address this problem. Injecting drug users are a high-risk group for hepatitis B virus (HBV) infection transmission, but vaccination programmes is poor. We aimed assess whether contingency management delivered in routine clinical practice increased completion HBV individuals receiving opioid substitution therapy.In our cluster randomised...
Recent case reports detail the successful use of temozolomide in management aggressive pituitary tumours. O(6)-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that counteracts effect temozolomide.To study MGMT expression tumours and consider whether associated with response to therapy tumours.We report two patients treated temozolomide, one who responded other did not. was assessed further 88 archived tumour samples.MGMT by immunohistochemistry. promoter methylation...
The etiology of sporadic pituitary tumors is currently unknown. Wnt pathways have been implicated in the pathogenesis a variety human tumors, but role these unclear. Microarray analysis using Affymetrix HG U133 plus 2.0 GeneChips identified four secreted frizzled-related protein (sFRP) family members pathway inhibitors that were differentially expressed both nonfunctioning and clinically functioning (n = 20) compared with normal controls 3). Reduced tumor expression inhibitory factor-1...
The aim of this study was to provide disease-specific information about schwannomatosis in its different forms and present 2 particular cases malignant schwannomas the context familial (FS).The authors analyzed patients with pathologically defined identified those varied schwannomatosis. Each case retrospectively for patient sex age, number operations tumors excised, symptoms, location size tumors, extent resection, nerve function pre- postoperatively, complications, other nonsurgically...
Abstract OBJECTIVE Grade I and II arteriovenous malformations (AVMs) have been considered safe to resect. However, unoperated low-grade AVMs not in previously reported series. The aim of this study was examine all cases, both operated unoperated, identify any characteristics that comprise a subgroup might pose relatively higher risk. METHODS A prospectively enrolled AVM database included 237 patients Spetzler-Martin or II. These were analyzed on the basis demographic characteristics,...
Clinical treatment decisions and the survival outcomes of patients with gliomas are directly impacted by accurate tumor classification. New more reliable prognostic markers needed to better identify variable duration among histologically defined glioma grades. Microarray expression analysis immunohistochemistry were used biomarkers associated aggressive biologic behaviors. The protein IQGAP1 IGFBP2, when in conjunction World Health Organization grading system, readily identified a subgroup...
Patients with glioblastoma (GBM) have variable clinical courses, but the factors that underlie this heterogeneity are not understood. To determine whether presence of telomerase-independent alternative lengthening telomeres (ALTs) mechanism is a significant prognostic factor for survival, we performed retrospective analysis 573 GBM patients. The ALT was identified in paraffin sections using combination immunofluorescence promyelocytic leukemia body and telomere fluorescence situ...
Loss of the cell adhesion protein E-cadherin is associated with invasion and metastasis in a number malignancies. Recent studies have highlighted that loss membrane expression may be accompanied by its detection nucleus, suggesting cellular redistribution during neoplasia. Pituitary tumors, although typically benign, locally invasive, membranous has been reported as marker prolactinomas.Our objective was to study pituitary adenomas, specifically whether nuclear occurs this...
Between 1989 and 2002 the authors treated 416 cases of angiographically confirmed arteriovenous malformations (AVMs) brain.Three hundred fifty-five patients underwent resection an AVM; 2% died 12% experienced a permanent morbidity (1.7% deterioration modified Rankin Scale [mRS] score 3-5). Patient outcomes in this series were based on Spetzler-Martin grade. For with Grade I II AVMs rate was 1% mortality 0.5%. III 18.9% (2.7% mRS 3-5) 2.7%. IV V 25.6% (5.1% 7.7%. No patient or lesion had...
Abstract Reduction in the mRNA and protein expression of lipocalin-like prostaglandin D2 (PGD2) synthase (PGDS), main arachidonic acid metabolite produced neurons glial cells central nervous system, is a significant biological event involved malignant progression astrocytomas predictive poor survival. In vitro, addition PGDS metabolite, PGD2, to A172 glioblastoma devoid resulted antiproliferative activity cell death. vitro PGD2 substitution also enhanced efficacy cyclo-oxygenase-2...
Grade I and II arteriovenous malformations (AVMs) have been considered safe to resect. However, unoperated low-grade AVMs not in previously reported series. The aim of this study was examine all cases, both operated unoperated, identify any characteristics that comprise a subgroup might pose relatively higher risk.A prospectively enrolled AVM database included 237 patients Spetzler-Martin or II. These were analyzed on the basis demographic characteristics, angiographic magnetic resonance...
✓ The authors report two cases of treatment by intraarterial papaverine cerebral vasospasm complicating the resection an arteriovenous malformation (AVM). Both had successful reversal documented on angiography. In first case sustained neurological improvement occurred, resulting in a normal outcome time discharge. second case, deterioration occurred with development edema. This complication was thought to be due perfusion pressure breakthrough, basis angiographic arterial vasodilation and...
Ependymomas arising from peripheral or spinal nerves are extremely rare. Other ectopic ependymomas found mostly in the sacrococcygeal region, possibly association with developmental anomalies. The case of an ependymoma a cranial nerve 40-year-old man is described.