A5078768852- Gastrointestinal disorders and treatments
- Pancreatic function and diabetes
- Intestinal Malrotation and Obstruction Disorders
- Testicular diseases and treatments
- Clinical Nutrition and Gastroenterology
- Pleural and Pulmonary Diseases
- Trauma Management and Diagnosis
- Hernia repair and management
- Abdominal Surgery and Complications
- Organ Transplantation Techniques and Outcomes
- Cancer Mechanisms and Therapy
- Vascular Tumors and Angiosarcomas
- Pediatric Hepatobiliary Diseases and Treatments
- Pneumothorax, Barotrauma, Emphysema
- Pancreatitis Pathology and Treatment
- Congenital Diaphragmatic Hernia Studies
- Foreign Body Medical Cases
- Liver Disease Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Minimally Invasive Surgical Techniques
- Chromatin Remodeling and Cancer
- Abdominal Trauma and Injuries
- Gastrointestinal Bleeding Diagnosis and Treatment
- Teratomas and Epidermoid Cysts
- interferon and immune responses
Chang Gung Children's Hospital
2009-2024
Linkou Chang Gung Memorial Hospital
2022-2024
Chang Gung University
2006-2024
Chang Gung Memorial Hospital
2009-2024
Children's Hospital of Pittsburgh
2017
University of Pittsburgh
2017
Boston Children's Hospital
2015
Autophagy is a major regulator of pancreatic beta cell homeostasis. Altered autophagic activity has been implicated in the cells patients with type 2 diabetes, and obese diabetic rodents. Here, we show that autophagy was induced by either high-fat diet or combined high-glucose diet, but not alone. However, intake alone did increase mass insulin secretion moderately. Depletion Atg7, necessary component pathway, intra-ductal AAV8-shAtg7 infusion C57BL/6 mice, resulted decreased mass, impaired...
Abstract Objectives IFI 27 is highly expressed in psoriatic lesions but its function has not been known. The present study aimed to explore role proliferation of epidermal keratinocytes. Materials and methods knockdown over‐expression keratinocytes were used compare their proliferation, by MTT assay, apoptosis (by annexin V binding) cell cycle progression flow cytometry. Formation cyclin A/ CDK 1 complex was examined a co‐immunoprecipitaion method. Anti‐proliferation effects also vivo...
Exendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that an agonist for the GLP-1 receptor, G-protein coupled receptor (GPCR). used to clinically improve glucose tolerance in diabetic patients due its ability enhance insulin secretion. In rodents, and possibly humans, exendin-4 can stimulate β-cell proliferation. The exact mechanism of action induce proliferation not well understood. Here, using specific epidermal growth factor (EGFR) null mouse, we show induced increase mass...
Many patients with chronic pancreatitis develop diabetes (chronic pancreatitis–related [CPRD]) through an undetermined mechanism. Here we used long-term partial pancreatic duct ligation (PDL) as a model to study CPRD. We found that PDL induced significant β-cell dedifferentiation, followed by time-dependent decrease in functional mass—all specifically the ligated tail portion of pancreas (PDL-tail). High levels transforming growth factor β1 (TGFβ1) were detected PDL-tail and mainly produced...
Duodenal ulcer (DU) causes various symptoms in children. The prevalence of Helicobacter pylori (Hp)-associated DU has been reducing some regions, yet the updated trend Taiwan is unknown. Risk factors recurrence have not comprehensively investigated This retrospective study included children diagnosed with to evaluate demographics, symptoms, diagnostics, treatment, and outcomes. Specific populations (infant, surgery required) were sorted for subgroup analysis. Predictors was analyzed patients...
There are no well-established indications for the surgical management of acute necrotizing pneumonitis in children. This study presents our experience regarding this challenging topic.Between 2002 and 2009, 56 patients with empyema were treated surgically. The outcomes analyzed retrospectively. Computed tomography findings massive lung necrosis or large cavities involving more than 50% involved lobe deemed to be complicated pneumonitis. Patients without above considered...
Various investigations have demonstrated that calcitonin gene-related peptide (CGRP) plays an important role in mediating ischemic preconditioning. CGRP has been shown to mimic the protective effects of preconditioning and mitigate ischemia-reperfusion (I/R) injury heart, brain, gastrointestinal system, other tissues. This study aimed examine whether CGRP, a proven intestinal cytoprotective molecule, exerted its through modulation inducible nitride oxide synthase (iNOS) apoptosis after I/R...
The data presented in this report revealed that pre-treatment of HB-EGF decreased the protein levels JNK phosphorylation, p38 and caspase −3 had been induced by intestinal I/R injury. These results may further support can protect injury through p38/MAPK pathway-dependent anti-apoptosis.
Laparoscopic surgery is commonly used for the treatment of many pediatric surgical diseases at our department. Single-incision laparoscopic (SILS) well-known its cosmetic benefit. We, hereby, present experience SILS and evaluate efficacy.From July 2012 to June 2014, 78 patients aged less than 18 years who underwent were retrospectively evaluated. There 44 males 34 females, with a mean age 10.3 years. The procedures included appendectomy (n = 64), reduction intussusception 8), removal an...
Objective Factors associated with testicular torsion (TT) and consequent orchiectomy in patients presenting to pediatric emergency departments (PEDs) scrotal pain (SP) are not well described. We report the factors predicting TT children SP. Methods The data on (aged ≤18 years) who presented SP PEDs at 4 branches of Chang Gung Hospital through 10 years were analyzed. Results In all, 256 Their mean age was 11.60 ± 4.61 72.7% (n = 186) aged 18 years. left-sided 54.7% 140) interval between onset...
Melanin, synthesized by melanocyte, is transferred to neighboring keratinocyte and finally accumulates in perinuclear site. Except functioning as an internal sunscreen protect from UV damage, the potential effect of melanin on modulating bioactivity has not yet been fully investigated. In this study, we added directly culture human epidermal keratinocytes uptake was found be dose- time-dependent determined spectrophotometric method. The uptaken accumulated perinuclearly that similar pattern...
Although the incidence of malignant sacrococcygeal germ cell tumors (MSGCTs) is high in East Asian countries, information about MSGCTs from this region limited. This report aimed to analyze data children with a single medical center Taiwan.Patients aged 18 years or younger primary recurrence teratoma who underwent surgery during neonatal period between January 1999 and December 2016 were identified Linkou Chang Gung Cancer Center registry. The clinical features, laboratory data, treatment...
Introduction: Dieulafoy lesion is an unusual cause of gastrointestinal bleeding in which significant, and often recurrent, hemorrhage occurs from a pinpoint non-ulcerated arterial lesion. It usually located gastric fundus, extremely rare children. Case Presentation: In this study, we present male adolescent with jejunal The patient was admitted to the hospital due hematochezia hypotension. No active bleeders were identified on endoscopy, colonoscopy, double-balloon enteroscopy. Computed...
Foreign body ingestion is a common occurrence in the pediatric population. We present case of 1-year-old infant boy who presented with abdominal distention and shock. At laparotomy, he was found to have an ileal perforation caused by wire from aluminum scouring pad that his parents were not aware had ingested. To our knowledge, this first report pad-related perforation. This emphasizes danger ingesting fragments metal importance considering foreign impaction workup gastrointestinal
Altered mental status can have many causes, some of which are life threatening, especially in children. In addition to the usual central nervous system and metabolic such as meningitis, encephalitis, seizure, electrolyte imbalance, inborn errors metabolism, less common causes altered status, if not diagnosed managed rapidly, poor consequences. We present a case child with life-threatening unusual cause mesenteric hernia hypovolemic shock. The was reduced successfully at laparotomy....
BackgroundEarly diagnosis and surgical intervention for midgut malrotation with bowel obstruction are crucial. We aimed to identify risk factors adverse outcomes in infants develop a prediction model.MethodsWe reviewed the operation records of surgically diagnosed at Chang Gung Children's Medical Center between January 2000 December 2020. Patients were classified into poor-outcome group (PO) if they underwent resection or experienced mortality; all others categorized as favorable-outcome...
Pediatric patients with short bowel syndrome (SBS) often require long-term parenteral nutrition and intravenous fluid support (PN) until enteral autonomy (EA). However, PN accounts for many complications. We aimed to investigate the outcome predictors of EA in these patients.
BackgroundVideo-assisted thoracoscopic bullectomy with pleurodesis is widely used to treat spontaneous pneumothorax. However, 1%–3% of patients experience postoperative complications that may require reoperation, such as bleeding or prolonged air leaks, and 3%–7% a repeat due recurrence. Therefore, modified procedure improved outcomes required.MethodsBetween January 1, 2011 December 31, 2015, 196 pneumothorax underwent without fixation the lung apex chest wall. In in group, was fixed wall...
Background: The purpose of this study is to assess the roles pediatric surgeons and adult trauma in management torso patients a Level I center. Methods: From 2015 2019, (age < 18 years) were studied. A comparison between who did not undergo surgery was performed. Older children (age: 10−18 compared with young adults 18−35 selected same criteria using propensity score matching (PSM) inverse probability treatment weighting (IPTW). Results: total 226 included study. Patients underwent for (N =...