A5081991094- Cardiovascular and exercise physiology
- Sports Performance and Training
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adipose Tissue and Metabolism
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Eicosanoids and Hypertension Pharmacology
- Mitochondrial Function and Pathology
- Advanced Glycation End Products research
- Exercise and Physiological Responses
- Nuclear Receptors and Signaling
- Cardiac Ischemia and Reperfusion
- Heart Rate Variability and Autonomic Control
- Neonatal and fetal brain pathology
- Sports injuries and prevention
- High Altitude and Hypoxia
- Adipokines, Inflammation, and Metabolic Diseases
- Fuel Cells and Related Materials
- Neuroscience of respiration and sleep
- Physical Activity and Health
- Optical Imaging and Spectroscopy Techniques
- Metabolomics and Mass Spectrometry Studies
- Sports and Physical Education Research
- Non-Invasive Vital Sign Monitoring
- Music Therapy and Health
Bursa Uludağ Üni̇versi̇tesi̇
2001-2023
Czech Academy of Sciences, Institute of Physiology
2021-2022
Adli Tıp Kurumu
2020
St George's, University of London
2000-2011
St George's Hospital
2000-2003
1. The maximal oxygen uptake (V(O(2),peak)) during dynamic muscular exercise is commonly taken as a crucial determinant of the ability to sustain high-intensity exercise. Considerably less attention, however, has been given rate at which V(O(2)) increases attain this maximum (or its submaximal requirement), and even kinetic features response following 2. Six, healthy, male volunteers (aged 22 58 years), each performed 13 tests: initial ramp-incremental cycle ergometry limit tolerance...
<i>Background:</i> Perinatal hypoxia-ischemia is a major cause of mortality and long-term neurological deficits. <i>Objectives:</i> The objective this study was to compare the effects two neuroprotective agents; magnesium sulfate melatonin, administered alone or in combination, on brain infarct volume TUNEL positivity neonatal hypoxic-ischemic (HI) rat model. <i>Methods:</i> After being anesthetized, 7-day-old pups (n = 80) underwent ischemia followed by...
Purpose: The objective of this study was to compare the effects two neuroprotective agents; melatonin, a free radical scavenger and topiramate, AMPA/kainate receptor antagonist, administered alone or in combination neonatal hypoxic-ischemic mod
The oxygen uptake response to moderate-intensity exercise (i.e. < anaerobic threshold (an)) has been characterised with a gain amplitude per increment of work rate) and time constant that do not vary appreciably at different rates or between the on- off-transients. Above an, becomes more complex an early component typically projects value similar response, but which is supplemented by addition delayed slow kinetic component. We therefore established target VO2 (VO21) for each subject such...
In this study, the effect and mechanisms of [Pyr1]apelin-13, dominant apelin isoform in human cardiovascular tissues plasma, on vascular contractility were investigated.The rings obtained from thoracic aortas male Wistar Albino rats placed isolated tissue bath system.After equilibration period, [Pyr1]apelin-13 (10 -9 to 10 -6 M) was applied cumulatively aortic pre-contracted with phenylephrine plateau phase.The protocol repeated presence specific signaling pathway inhibitors (F13A, L-NAME,...
Irisin, a newly identified exercise-derived myokine, has been found involved in peripheral vasodilator effect. However, little is known regarding the potential vascular activity of irisin, and mechanisms underlying its effects on smooth muscle have not fully elucidated. This study was aimed to investigate irisin contractility rat thoracic aorta, hypothesis that protein kinase C (PKC) may role these effects.Isometric contraction-relaxation responses aorta rings were measured with an isolated...
In this study, the effect and mechanisms of [Pyr1]apelin-13, dominant apelin isoform in human cardiovascular tissues plasma, on vascular contractility were investigated. The rings obtained from thoracic aortas male Wistar Albino rats placed isolated tissue bath system. After equilibration period, [Pyr1]apelin-13 (10-9 to 10-6 M) was applied cumulatively aortic pre-contracted with phenylephrine plateau phase. protocol repeated presence specific signaling pathway inhibitors (F13A, L-NAME,...
Background/Objective: This study aimed to investigate the effects of irisin on rat tracheal smooth muscle contraction-relaxation responses and roles voltage-gated potassium (KV) channels, ATP-sensitive (KATP) large-conductance calcium-activated (BKCa) channels in these effects. Methods: Isometric contraction relaxation segments were measured using tissue bath method. Submaximal contractions induced by ACh (10-5 M) or KCl (60 mM), then concentration-response curves (10-9 10-6 obtained. For...
Bu derleme, irisin hakkındaki mevcut bilgileri ve irisinin vasküler tonusa aracılık etmedeki etkin rolünü özetleme çabasıdır. Egzersiz kronik, bulaşıcı olmayan hastalıkların, tip 2 diyabetin özellikle kardiyovasküler hastalıkların önlenmesinde bir dayanak noktasıdır. Egzersiz/fiziksel aktiviteye yanıt olarak üretilen yeni miyokin olan irisin, beyaz yağ dokusunun ‘esmerleşmesini’ teşvik ederek enerji harcamalarında artışa neden olur. hormonun ilk tanımında, öncül fibronektin III alan içeren...
This study investigated the effects of irisin on vascular smooth muscle contractility in rat thoracic aorta, and hypothesis that mitogen-activated protein kinase (MEK1/2) signaling pathway, voltage-gated potassium (KV) channels, small-conductance calcium-activated (SKCa) large-conductance (BKCa) channels may have roles these effects. Isometric contraction-relaxation responses isolated aorta rings were measured with an organ bath model. The steady contraction was induced 10-5 M phenylephrine...
Apelin is a newly discovered peptide hormone and originally endogenous apelin receptor ligand.In this study, we aimed to investigate the possible roles of potassium channel subtypes in vasorelaxant effect mechanisms apelin.The vascular rings obtained from thoracic aortas male Wistar Albino rats were placed into isolated tissue bath system. The resting tension was set 2 g. After equilibration period, aortic precontracted with 10-5 M phenylephrine (PHE) or 45 mM KCl. Pyroglutamyl-apelin-13...
Background/aim: Irisin, a newly identified exercise-derived myokine, has been found involved in peripheral vasodilator effect.However, little is known regarding the potential vascular activity of irisin, and mechanisms underlying its effects on smooth muscle have not fully elucidated.This study was aimed to investigate irisin contractility rat thoracic aorta, hypothesis that protein kinase C (PKC) may role these effects. Materials methods:Isometric contraction-relaxation responses aorta...