A5081315058- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Circular RNAs in diseases
- Cancer-related gene regulation
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Nutrition and Health in Aging
- Lung Cancer Treatments and Mutations
- Higher Education and Teaching Methods
- Second Language Learning and Teaching
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Esophageal and GI Pathology
- EFL/ESL Teaching and Learning
- Ectopic Pregnancy Diagnosis and Management
- Protein Degradation and Inhibitors
- Ideological and Political Education
- Liver Disease Diagnosis and Treatment
- Gestational Trophoblastic Disease Studies
Anyang Tumor Hospital
2019-2025
Beijing Friendship Hospital
2014-2024
Capital Medical University
2014-2024
Shanghai Shipbuilding Technology Research Institute
2024
First Affiliated Hospital of Henan University
2024
Fujian Agriculture and Forestry University
2023
The Fourth People's Hospital of Zibo City
2023
Xianyang Normal University
2022
Henan University of Science and Technology
2020
Sichuan University
2017-2018
Yellow catfish (Pelteobagrus fulvidraco) is one of the most important freshwater aquaculture species in China. However, its small size and lower meat yield limit edible value. Myostatin (MSTN) a negative regulator mammalian muscle growth. But, function Mstn fish remains elusive. To explore roles mstn gene growth create strain yellow with high amount mass, we performed targeted disruption using engineered zinc-finger nucleases (ZFNs). Employing zebrafish embryos as screening system to...
Background Cesarean scar pregnancy (CSP) is a very rare but life-threatening entity and there no optimal management strategy. Here we report successfully conservative treatment of CSP. Methods We retrospectively analyzed the clinical data 54 women with CSP, who underwent uterine artery embolization between January 2007 September 2012 at Peking University People's Hospital. evaluated outcomes, technique complications embolization. Results Of patients, 2 patients hemorrhage after induced...
Myostatin (Mstn), a member of the transforming growth factor β superfamily, plays an inhibiting role in mammalian muscle growth. Mammals like human, cattle, mouse, sheep, and dog carrying null alleles Mstn display double-muscle phenotype. is conserved fish; however, little known whether fish with mutated mstn similar phenotype to mammals because lack mutant alleles. Previously, we knocked out one duplicated copies myostatin gene (mstna) yellow catfish using zinc-finger nucleases. In this...
Abstract Lung cancer is the main health threat in world. Recently, oleuropein has been reported to have potent antioxidant and anticancer activities. However, antitumor effects of on H1299 cells are not well understood. Therefore, purpose this paper tantamount explore its underlying mechanism that may be involved. Oleuropein treatment resulted cell cycle distribution at G 2 /M arrest apoptosis a dose‐dependent manner. Mitochondria‐mediated was verified by increase Bax/Bcl‐2 ratio, release...
Engineered endonucleases are a powerful tool for editing DNA. However, sequence preferences may limit their application. We engineer structure-guided endonuclease (SGN) composed of flap endonuclease-1 (FEN-1), which recognizes the 3′ structure, and cleavage domain Fok I (Fn1), cleaves DNA strands. The SGN target on basis structure formed between guide (gDNA) cut through its Fn1 dimerization. Our results show that SGN, guided by pair gDNAs, transgenic reporter gene endogenous genes in...
Abstract Esophageal squamous cell carcinoma (ESCC) is a highly prevalent and aggressive malignancy, timely diagnosis of ESCC contributes to an increased cancer survival rate. However, current detection methods for mainly rely on endoscopic examination, limited by relatively low participation Herein, ferric‐particle‐enhanced laser desorption/ionization mass spectrometry (FPELDI MS) utilized record the serum metabolic fingerprints (SMFs) from retrospective cohort (523 non‐ESCC participants 462...
Targeted drug therapy and transcatheter arterial chemoembolization (TACE) is the most effective control method for middle late-stage hepatocellular carcinoma (HCC). Regorafenib as second-line treatment of patients with advanced HCC, combined TACE still achieved good results in clinic. However, there no relevant research at present. This study was to investigate efficacy safety regorafenib HCC after failure first-line targeted treatment.Fifty-nine received between October 2019 September 2021...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a malignant condition in humans. Anoikis related genes (ARGs) are crucial to cancer progression. Therefore, more studies on the relationship between ARGs and ESCC warranted. Methods The study acquired ESCC-related transcriptome data from genome atlas (TCGA). Differentially expressed (DE-ARGs) were obtained by performing differential analysis training set, candidates filtered out survival of high low expression groups DE-ARGs....
Background: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy with high incidence. This study aimed to reveal the complete circRNA-miRNA-mRNA regulatory network in ESCC and validate its function mechanism. Method: Expression of OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 2 (OTUB2) was analyzed by bioinformatics find binding sites between circRNA6448-14 miR-455-3p, as well miR-455-3p OTUB2. The relationships were verified RNA Immunoprecipitation (RIP)...
Esophageal squamous cell carcinoma (ESCC) is a malignant condition in humans. Anoikis-related genes (ARGs) are crucial to cancer progression. Therefore, more studies on the relationship between ARGs and ESCC warranted.
Aim: Accumulating evidence suggested that challenge of the maternal–fetal interaction during pregnancy might cause impairment immunological hemostasis and lead to gestational diabetes mellitus (GDM) pathological process. Immune checkpoint molecule PD-1 is one critical balancing immune response tolerance. Methods: expressions on T-cell subsets GDM patients control groups were measured via flow cytometric analysis followed up. Results: Downregulation acted as an indicator for occurrence in...
Proton pump inhibitors (PPIs) have been reported to be associated with cholangitis and might possibly carcinogenic. However, few studies conducted investigate the association of PPIs cholangiocarcinoma (CCA). Thus, a hospital-based case-control study was carried out in China explore between CCA.In this study, 1468 CCA cases (826 intrahepatic (ICC) 642 extrahepatic (ECC)) were included, which observed at Beijing Friendship Hospital, from February 2002 October 2018. We retrospectively...
Esophageal squamous cell carcinoma (ESCC) is a lethal gastrointestinal malignancy worldwide. We aimed to identify an angiogenesis-related lncRNAs (ARlncRNAs) signature that could predict the prognosis in ESCC. The GSE53624 and GSE53622 datasets were derived from GEO database. differently expressed ARlncRNAs (DEARlncRNAs) retrieved by weighted gene co-expression network analysis (WGCNA), differential expression analysis, correlation analysis. Optimal lncRNA biomarkers screened training set...
Botrytis cinerea is a devastating fungal pathogen that causes severe economic losses in global tomato cultivation. Understanding the molecular mechanisms driving tomatoes' response to this crucial for developing effective strategies counter it. Although Micro-Tom (MT) cultivar has been used as model, its stage-specific B. remains poorly understood. In study, we examined of MT and Ailsa Craig (AC) cultivars at different time points (12-48 h post-infection (hpi)). Our results indicated...
Background miR-4270 is a regulatory factor has been linked with the progression of various cancers, such as nasopharyngeal carcinoma, hepatocellular carcinoma (HCC), and gastric cancer. However, underlying mechanisms through which modulates HCC development are not fully understood. Methods expression levels were analyzed in cell lines tissue samples. An online bioinformatics tool was then utilized to predict target gene. The binding relationship between its gene DNMT3A verified using...
To evaluate the prognostic value of skeletal muscle index (SMI) and its change in patients with hepatocellular carcinoma (HCC) experiencing curative hepatectomy plus adjuvant transarterial chemoembolization (TACE).A total 62 HCC who underwent TACE after were analysed retrospectively. Skeletal area at third lumbar level was quantitated using computed tomography images normalized for height squared to obtain (SMI). loss (SML) over 6 months two SMIs before TACE. Correlation analyses preformed...
At present, there is no standard for the posterior treatment of hepatocellular carcinoma (HCC). This study isTo evaluate and compare safety efficacy transcatheter arterial chemoembolization (TACE) combined with regorafenib anti-PD-1 antibody continued TACE in patients HCC after failure second-line regorafenib.We enrolled advanced who were treated sorafenib sequential regorafenib. All found to have tumor progression 2021. After progression, PD-1 or according wishes patient. Efficacy was...