A5101915372- RNA Interference and Gene Delivery
- Prostate Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Advanced X-ray and CT Imaging
- Urologic and reproductive health conditions
- Prostate Cancer Treatment and Research
- Endoplasmic Reticulum Stress and Disease
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cardiovascular Health and Risk Factors
- Advanced biosensing and bioanalysis techniques
- NF-κB Signaling Pathways
- Advanced MRI Techniques and Applications
- Machine Learning in Bioinformatics
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Research and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- RNA modifications and cancer
- Pediatric Urology and Nephrology Studies
- Congenital Heart Disease Studies
- Microbial Inactivation Methods
- Metabolomics and Mass Spectrometry Studies
- Bone Metabolism and Diseases
- Urological Disorders and Treatments
- Chronic Disease Management Strategies
Hebei Provincial Center for Disease Control and Prevention
2020-2025
Sir Run Run Shaw Hospital
2024
Hainan University
2022
University Hospital Heidelberg
2021
Heidelberg University
2021
Taian City Central Hospital
2014-2021
Princess Margaret Cancer Centre
2021
University Health Network
2021
Guizhou Provincial People's Hospital
2019
Purdue University West Lafayette
2018
The balance between bone formation and resorption is compromised in diabetes, which may contribute to the high risk of fractures diabetic patients. However, mechanism by glucose affects turnover remains be elucidated. present study demonstrated that inhibited receptor activator nuclear factor‑κB ligand (RANKL)‑induced osteoclastogenesis. In order examine involved inhibition osteoclastogenesis, examined several key molecules osteoclast differentiation, including v‑ATPase V0 subunit d2...
Objective: To analyze the prevalence of chronic kidney disease (CKD) and influencing factors adults in Hebei Province, provide scientific evidence for development comprehensive CKD prevention control strategies. Methods: In China Adult Chronic Disease Nutrition Surveillance 2018, a total 7 562 permanent residents aged ≥18 years were selected by multi-stage stratified cluster random sampling from 13 surveillance points questionnaire survey, medical examination laboratory test. Results: A 1...
Oxidized HDL (ox-HDL), unlike native that exerts antiatherogenic effects, plays a proatherogenic role. However, the underlying mechanisms are not completely understood. This study was designed to explore inductive effect of ox-HDL on endoplasmic reticulum (ER) stress-CCAAT-enhancer-binding protein homologous (CHOP)-mediated macrophage apoptosis and its upstream mechanisms. Our results showed could be ingested by macrophages, causing intracellular lipid accumulation. As with tunicamycin (an...
Background: We previously confirmed the targeting of high-mobility group box 1 (HMGB1) by miR-25. This project aims to further investigate whether miR-25 improves myocardial ischemia-reperfusion injury (IRI) in vivo HMGB1. Methods: A rat model IRI was established ligation left anterior descending coronary artery for 45 minutes followed 2, 4, or 6 hours reperfusion. The expression miR-25, HMGB1, and apoptosis-related proteins myocardium determined quantitative real-time polymerase chain...
Prostate cancer cells must maintain or achieve the further ability of proliferation during progression. The molecular mechanisms, however, remain poorly understood. We identified a novel oncogene, termed membrane-spanning 4-domains, subfamily A, member 8B (MS4A8B), over-expressed in prostate cancer.We firstly detected MS4A8B mRNA 13 types paired human normal and tissues by real-time polymerase chain reaction (RT-PCR). In 140 clinically localized samples from radical prostatectomy,...
Abstract Objective We aimed to evaluate the role of tumor size in predicting risk for localized prostate cancer (PCa) patients undergoing radical prostatectomy (RP). Methods Twenty‐five thousand, one hundred twenty‐seven men with PCa receiving RP from 2010 2015 were extracted Surveillance, Epidemiology, and End Results database. Kaplan–Meier plots multivariable Cox regression analyses used illustrate overall survival (OS) according size. The was confirmed by postoperative pathology after RP....
Abstract We describe a woman with flank pain and hydronephrosis. Computed tomography (CT) urography maximum intensity projection (MIP) reformatted images clearly showed that long finger‐like intraluminal filling defects mass in the left middle ureter. The pathologic biopsy by ureteroscopy revealed lesion mainly consists of benign fibrinoid necrosis. A large soft smooth, spindle‐like, dark brown (approximately 13.5 cm length) was identified ureter when open surgery performed. segment part...
This protocol details a method to analyze two tissue samples at the transcriptomic level using microarray analysis, ingenuity pathway analysis (IPA) and gene set enrichment (GSEA). Methods such as these provide insight into mechanisms underlying biological differences across thus can be applied interrogate variety of processes different samples, conditions, like. The full detailed below determine effects muscle-specific Notch1 activation in mdx mouse model previously published data human...
To investigate the application of Enhanced Recovery After Surgery (ERAS) in nursing care patients undergoing Thulium laser prostatectomy and analyze factors affecting postoperative complications.
When this article was originally published in The Prostate 22852:911–922 (2014), it contained errors the affiliations of Sheng Li, Feng Yue, and Na Wang. have now been corrected as shown above. We regret error.
Abstract Introduction: Exploring functional connectivity (FC) alterations is important for the understanding of underlying neuronal network in subjective cognitive decline (SCD). The objective this study was to prove that dynamic FC can better reflect changes brain function individuals with SCD compared static FC, and further explore association between amyloid pathology preclinical stage Alzheimer’s disease (AD). Methods: 101 normal control (NC) subjects, 97 SCDs, 55 impairment (CI)...
Abstract The mitochondrial serine protease ClpXP regulates the integrity of respiratory chain by degrading damaged and/or misfolded proteins. This is over-expressed in multiple malignancies and inhibiting or hyperactivating it kills malignant cells vitro vivo. In Bacillus subtilis, bacterial homologue recognizes proteins tagged with phosphor-arginine for degradation. Yet, unknown how To determine phosphorylated amino acids influence ClpXP-mediated protein degradation, we incubated...