A5022636698- Radiomics and Machine Learning in Medical Imaging
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Genomics and Diagnostics
- Tuberculosis Research and Epidemiology
- Epigenetics and DNA Methylation
- Science, Research, and Medicine
- Biomedical Ethics and Regulation
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- HIV/AIDS drug development and treatment
- MRI in cancer diagnosis
- Gene expression and cancer classification
- CRISPR and Genetic Engineering
- Hemoglobinopathies and Related Disorders
- Prenatal Screening and Diagnostics
- Cancer-related Molecular Pathways
- Traditional Chinese Medicine Studies
- Mycobacterium research and diagnosis
- Genomics and Chromatin Dynamics
- Genetics, Bioinformatics, and Biomedical Research
- Advanced MRI Techniques and Applications
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Tracheal and airway disorders
Zhuzhou Central Hospital
2024-2025
Central South University
2024-2025
Xijing Hospital
2013-2024
University of South China
2023
Shandong First Medical University
2023
Shandong Tumor Hospital
2023
Air Force Medical University
2013-2022
St. Jude Children's Research Hospital
2018-2022
Shenyang Pharmaceutical University
2022
Mayo Clinic in Arizona
2019
Allogeneic hematopoietic stem-cell transplantation for X-linked severe combined immunodeficiency (SCID-X1) often fails to reconstitute immunity associated with T cells, B and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemotherapy is given. In previous studies, autologous gene therapy γ-retroviral vectors failed B-cell NK-cell was complicated by vector-related leukemia.We performed a dual-center, phase 1-2 safety efficacy study of lentiviral vector...
Silver nanoparticles (AgNPs) are incorporated into medical and consumer products to exploit their excellent antimicrobial properties; however, potential mechanisms of toxicity AgNPs in mammalian cells not fully understood. The objective this study was determine the mechanism size- concentration-dependent cytotoxicity human liver-derived hepatoma (HepG2) cells. Mechanisms were explored at subcytotoxic concentrations (≤10 µg/ml AgNPs) autophagy induction, lysosomal activity,...
Abstract Effective data sharing is key to accelerating research improve diagnostic precision, treatment efficacy, and long-term survival in pediatric cancer other childhood catastrophic diseases. We present St. Jude Cloud (https://www.stjude.cloud), a cloud-based data-sharing ecosystem for accessing, analyzing, visualizing genomic from >10,000 patients with survivors, >800 sickle cell patients. Harmonized totaling 1.25 petabytes are freely available, including 12,104 whole...
Abstract Background The hypoxic tumor microenvironment is a key factor that promotes metabolic reprogramming and vascular mimicry (VM) in ovarian cancer (OC) patients. ESM1, secreted protein, plays an important role promoting proliferation angiogenesis OC. However, the of ESM1 VM OC patients has not been determined. Methods Liquid chromatography coupled with tandem MS was used to analyze CAOV3 OV90 cells. Interactions between PKM2, UBA2, SUMO1 were detected by GST pull-down, Co-IP, molecular...
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental with prevalence of 0.9–2.6%. Twin studies showed heritability 38–90%, indicating strong genetic contributions. Yet it unclear how many genes have been associated ASD and the evidence is. A comprehensive review analysis literature data may bring clearer big picture autism genetics. We show that as 2193 genes, 2806 SNPs/VNTRs, 4544 copy number variations (CNVs) 158 linkage regions by GWAS, genome-wide CNV studies, analyses,...
Transcription factors (TFs) play key roles in both development and stress responses. By integrating into rewiring original systems, novel TFs contribute significantly to the evolution of transcriptional regulatory networks. Here, we report a high-confidence map covering 388 from 47 families Arabidopsis. Systematic analysis this revealed architectural heterogeneity developmental response subnetworks identified three types network motifs that are absent unicellular organisms essential for...
Disruption of the retinoblastoma (RB) tumor suppressor pathway, either through genetic mutation upstream regulatory components or RB1 itself, is believed to be a required event in cancer. However, alterations RB-regulated E2F family transcription factors are infrequent, casting doubt on direct role for E2Fs driving In this work, analysis human cancer revealed subtle but impactful copy number gains E2F1 and E2F3 hepatocellular carcinoma (HCC). Using series loss- gain-of-function alleles dial...
E2F-mediated transcriptional repression of cell cycle–dependent gene expression is critical for the control cellular proliferation, survival, and development. E2F signaling also interacts with programs that are downstream genetic predictors cancer development, including hepatocellular carcinoma (HCC). Here, we evaluated function atypical repressor genes E2f7 E2f8 in adult liver physiology. Using several loss-of-function alleles mice, determined combined deletion hepatocytes leads to HCC....
ABSTRACT Pneumocystis carinii f. sp. hominis isolates from 207 clinical specimens nine countries were typed based on nucleotide sequence variations in the internal transcribed spacer regions I and II (ITS1 ITS2, respectively) of rRNA genes. The number ITS1 nucleotides has been revised previously reported 157 bp to 161 bp. Likewise, ITS2 changed 177 192 types increased 2 15, that 3 14. 15 are designated A through O, 14 named a n. total 59 P. found this study.
Long noncoding RNAs (lncRNAs) have been shown to play essential roles in almost every important biological process through multiple mechanisms. Although the repertoire of human lncRNAs has rapidly expanded, their function and regulation remain largely elusive, calling for a systematic integrative annotation tool. Here we present AnnoLnc ( http://annolnc.cbi.pku.edu.cn ), one-stop portal systematically annotating novel lncRNAs. Based on more than 700 data sources various tool chains, enables...
Abstract Background Non-invasive discrimination between lung squamous cell carcinoma (LUSC) and adenocarcinoma (LUAD) subtypes of non-small-cell cancer (NSCLC) could be very beneficial to the patients unfit for invasive diagnostic procedures. The aim this study was investigate feasibility utilizing multimodal magnetic resonance imaging (MRI) radiomics clinical features in classifying NSCLC. This retrospective involved 148 eligible with postoperative pathologically confirmed conducted three...
Cisplatin chemotherapy is an important treatment for advanced ovarian cancer (OC). However, the development of cisplatin resistance greatly limits survival time OC patients. Endothelial cell-specific molecule 1 (ESM1) has been found to be proto-oncogene promoting OC, but its mediating remains unknown. We used quantitative polymerase chain reaction (qPCR) measure transcription levels ESM1, Growth arrest specific transcript 5 (GAS5), miR-23a-3p, and Phosphatase And Tensin Homolog (PTEN). A...
Pneumocystis carinii pneumonia (PCP) is an important cause of morbidity and death among persons with human immunodeficiency virus (HIV) infection. Polymerase chain reaction (PCR) analysis respiratory specimens has been investigated as a rapid diagnostic method. We have previously reported on the utility this technique for diagnosing PCP in HIV-infected patients. In report we evaluate PCR used blinded study design to avoid biases inherent retrospective nonblinded studies. The diagnosis was...
Dendritic spines serve as the postsynaptic platform for most excitatory synapses in mammalian brain, and their shape size are tightly correlated with synaptic strength. The actin cytoskeleton plays a crucial role spine structure its modifications during synapse development plasticity, but underlying regulatory mechanisms remain to be elucidated. Here, we report that capping protein (CP), regulator of filament growth, an essential formation. We found CP expression rat hippocampus is elevated...
Emerging evidence suggests that diffusion-weighted magnetic resonance imaging (DW MRI) could be useful for tumor detection with N and M staging of lung cancer in place fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). DW MRI at 3.0 T FDG PET/CT were performed before therapy 113 patients pulmonary nodules. Mean apparent diffusion coefficient (ADC), maximal standardized uptake value (SUVmax ) Ki-67 scores assessed. Quantitatively, specificity...
Inactivation of phosphatase and tensin homology deleted on chromosome 10 ( PTEN ) is linked to increased PI3K–AKT signaling, enhanced organismal growth, cancer development. Here we generated analyzed Pten knock-in mice harboring a C2 domain missense mutation at phenylalanine 341 FV ), found in human cancer. Despite having reduced levels protein, homozygous FV/FV embryos have intact AKT develop normally, are carried term. Heterozygous /+ carcinoma the thymus, stomach, adrenal medulla, mammary...