A5101198725- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Photosynthetic Processes and Mechanisms
- Genomics and Chromatin Dynamics
- Alzheimer's disease research and treatments
- Plant Reproductive Biology
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Plant biochemistry and biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- Plant Stress Responses and Tolerance
- Pesticide Residue Analysis and Safety
- DNA and Biological Computing
- Chromosomal and Genetic Variations
- Memory and Neural Mechanisms
- Dementia and Cognitive Impairment Research
- Chalcogenide Semiconductor Thin Films
- Neurological Disease Mechanisms and Treatments
- Advanced Proteomics Techniques and Applications
- Genetically Modified Organisms Research
- Heat shock proteins research
- Medical Imaging Techniques and Applications
- Plant-Microbe Interactions and Immunity
- Plant nutrient uptake and metabolism
Huashan Hospital
2024-2025
Fudan University
2024-2025
Peking University
2006-2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai East Hospital
2024
Tongji University
2024
China-Japan Friendship Hospital
2024
Xi'an Polytechnic University
2023
National Center of Biomedical Analysis
2011-2023
The transcription factor LONG HYPOCOTYL5 (HY5) acts downstream of multiple families the photoreceptors and promotes photomorphogenesis. Although it is well accepted that HY5 to regulate target gene expression, in vivo binding any its promoters has yet be demonstrated. Here, we used a chromatin immunoprecipitation procedure verify suspected sites. We demonstrated association with promoter targets not altered under distinct light qualities or during light-to-dark transition. Coupled DNA chip...
Abstract We present high-resolution maps of DNA methylation and H3K4 di- trimethylation two entire chromosomes fully sequenced centromeres in rice (Oryza sativa) shoots cultured cells. This analysis reveals combinatorial interactions between these epigenetic modifications chromatin structure gene expression. Cytologically densely stained heterochromatin had less H3K4me2 H3K4me3 more methylated than the euchromatin, whereas a unique composition. Most transposable elements highly but no...
To elucidate genome-level responses to drought and high-salinity stress in rice, a 70mer oligomer microarray covering 36,926 unique genes or gene models was used profile genome expression changes rice shoot, flag leaf panicle under conditions. While patterns of response within particular organ type showed significant overlap, comparison profiles among different organs largely organ-specific regulation. Moreover, both stresses appear alter the number involved transcription cell signaling...
Transcription factors (TFs) play key roles in both development and stress responses. By integrating into rewiring original systems, novel TFs contribute significantly to the evolution of transcriptional regulatory networks. Here, we report a high-confidence map covering 388 from 47 families Arabidopsis. Systematic analysis this revealed architectural heterogeneity developmental response subnetworks identified three types network motifs that are absent unicellular organisms essential for...
MYB transcription factor genes play important roles in many developmental processes and various defence responses of plants. Two Arabidopsis R2R3-type genes, AtMYB59 AtMYB48, were found to undergo similar alternative splicing. Both have four distinctively spliced transcripts that encode either MYB-related proteins or R2R3-MYB proteins. An extensive BLAST search the GenBank database resulted finding cloning two rice homologues, both which also share a splicing pattern. In semi-quantitative...
PlantMetabolomics.org (PM) is a web portal and database for exploring, visualizing, downloading plant metabolomics data. Widespread public access to well-annotated datasets essential establishing as functional genomics tool. PM integrates data generated from different analytical platforms multiple laboratories along with the key visualization tools such ratio error plots. Visualization can quickly show how one condition compares another which largest changes. The tries capture complete...
Metabolomics is the methodology that identifies and measures global pools of small molecules (of less than about 1,000 Daltons) a biological sample, which are collectively called metabolome. can therefore reveal metabolic outcome genetic or environmental perturbation regulatory network, thus provide insights into structure regulation network. Because chemical complexity metabolome limitations associated with individual analytical platforms for determining metabolome, it currently difficult...
A brief history of SnO 2 -based PSCs development in recent years and the advantages as ETL.
Background Urinary formic acid (FA) has been reported to be a biomarker for Alzheimer's disease (AD). However, the association between FA and pathological changes in memory clinic patients is currently unclear. Objective This study aims investigate associations across different cognitive statuses patients. Methods A cohort of with mild impairment (MCI-Aβ- n = 37, MCI-Aβ+ 33), AD dementia (n 39), cognitively normal subjects (CN-Aβ- 98, CN-Aβ+ 50) were included. Comprehensive...
Abstract INTRODUCTION To investigate the associations of metabotropic glutamate receptor 5 (mGluR5) with tau deposition and cognitive ability in patients early Alzheimer's disease (AD). METHODS Twenty‐six cognitively impaired (CI) 14 unimpaired (CU) individuals underwent mGluR5 positron emission tomography (PET) ([ 18 F]PSS232), amyloid PET F]florbetapir), F]MK6240), neuropsychological assessment. The relationships among availability, deposition, assessment were analyzed using Spearman's...
Abstract Purpose: PET imaging targeting the purinergic receptor subtype 7 (P2X7R) is of high interest for assessing glioma microenvironment. No reports were published regarding P2X7R in gliomas. Therefore, we compared uptake characteristics 18F-GSK1482160, a novel ligand, to conventional 11C-MET and contrast-enhanced MRI patients with Experimental Design: Thirteen (8 grade II, 5 III/IV) at initial diagnosis consecutively included underwent 18F-GSK1482160 PET, MRI. The semi-quantitative...
Plasma phosphorylated tau 181 (p-tau-181) and glial fibrillary acidic protein (GFAP) have potential predictive value for identifying synaptic density as measured using 18 F-SynVesT-1 brain PET; the relationship of plasma p-tau-181 GFAP with synapse loss might be influenced by aggregation rather than amyloid-β deposition or cortical thickness.
Modern cybersecurity built on public-key cryptosystems like Rivest-Shamir-Adleman is compromised upon finding solutions to the prime factorization. Nevertheless, solving factorization problem, given a large N, remains computationally challenging. Here, we design DNA origami frameworks (DOFs) direct localized assembly of double-crossover (DX) tiles for with model consisting computing, decision-making, and reporting motifs. The implementation based sequential different DX in DOF cavity that...
Abstract Summary:NTAP is designed to analyze ChIP-chip data generated by the NimbleGen tiling array platform and accomplish various pattern recognition tasks that are useful especially for epigenetic studies. The modular design of NTAP makes processing highly customizable. Users can either use perform full process analysis, or choose post-processing modules in pre-processed other platforms. output be saved standard GFF format files visualized GBrowse. Availability Implementation:The source...
Molecular docking is a pivotal process in drug discovery. While traditional techniques rely on extensive sampling and simulation governed by physical principles, these methods are often slow costly. The advent of deep learning-based approaches has shown significant promise, offering increases both accuracy efficiency. Building upon the foundational work FABind, model designed with focus speed accuracy, we present FABind+, an enhanced iteration that largely boosts performance its predecessor....
To explore the clinical characteristics and pathogenic variant in a child with Cantú syndrome (CS).
<title>Abstract</title> Traumatic brain injury (TBI) is a prevalent neurosurgical condition that can lead to significant disability and mortality. This study investigates the role of long non-coding RNAs (lncRNAs) pyroptosis in neuroinflammation during acute phase post-TBI. We analyzed 58 pyroptosis-related genes through mRNA-seq injured 33 mice subjected controlled cortical impact (CCI), organized into 11 groups with different time points (0, 1, 2, 3, 4, 6, 12, 24, 72, 148 hours), including...