Darrell Gentry
A5039071943- Cancer Genomics and Diagnostics
- Genetics, Bioinformatics, and Biomedical Research
- Epigenetics and DNA Methylation
- Gene expression and cancer classification
- Prenatal Screening and Diagnostics
- Genomics and Rare Diseases
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Cancer Research and Treatments
- Protein Degradation and Inhibitors
- Virus-based gene therapy research
St. Jude Children's Research Hospital
2020-2021
Abstract Effective data sharing is key to accelerating research improve diagnostic precision, treatment efficacy, and long-term survival in pediatric cancer other childhood catastrophic diseases. We present St. Jude Cloud (https://www.stjude.cloud), a cloud-based data-sharing ecosystem for accessing, analyzing, visualizing genomic from >10,000 patients with survivors, >800 sickle cell patients. Harmonized totaling 1.25 petabytes are freely available, including 12,104 whole...
ABSTRACT Effective data sharing is key to accelerating research that will improve the precision of diagnoses, efficacy treatments and long-term survival pediatric cancer other childhood catastrophic diseases. We present St. Jude Cloud ( https://www.stjude.cloud ), a cloud-based ecosystem developed via collaboration between Children’s Research Hospital, DNAnexus, Microsoft, for accessing, analyzing visualizing genomic from >10,000 patients, survivors >800 sickle cell patients....
Abstract Pediatric brain tumors comprise a distinct spectrum of diseases compared to adult and are distinguished by their unique clinical histopathological features, developmental context, mutation burden, genomic, epigenomic, transcriptomic alterations. Access in vivo models that recapitulate pediatric has been limited inadequate represent these heterogeneous diseases. Here we introduce the Brain Tumor Portal (PBTP, pbtp.stjude.cloud), an open resource access molecular characterization,...
<div>Abstract<p>Effective data sharing is key to accelerating research improve diagnostic precision, treatment efficacy, and long-term survival in pediatric cancer other childhood catastrophic diseases. We present St. Jude Cloud (<a href="https://www.stjude.cloud" target="_blank">https://www.stjude.cloud</a>), a cloud-based data-sharing ecosystem for accessing, analyzing, visualizing genomic from >10,000 patients with survivors, >800 sickle cell patients....
<div>Abstract<p>Effective data sharing is key to accelerating research improve diagnostic precision, treatment efficacy, and long-term survival in pediatric cancer other childhood catastrophic diseases. We present St. Jude Cloud (<a href="https://www.stjude.cloud" target="_blank">https://www.stjude.cloud</a>), a cloud-based data-sharing ecosystem for accessing, analyzing, visualizing genomic from >10,000 patients with survivors, >800 sickle cell patients....
<p>Involves Supplementary Table Legends and Figures associated legends</p>
<p>Involves Supplementary Table Legends and Figures associated legends</p>
Abstract Despite making significant advances over the past 25 years in our understanding of most common adult solid tumors, much less is known about childhood tumors. We have previously described a protocol to produce orthotopic patient-derived xenografts (O-PDX) at diagnosis, recurrence and autopsy. These O-PDX models provide both vivo vitro systems study mechanisms disease origin, tumor progression preclinical testing. Here, we present an innovative cloud-based all-in-one data portal...