A5063787089- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- MRI in cancer diagnosis
- AI in cancer detection
- Urologic and reproductive health conditions
- Sexual function and dysfunction studies
- Digital Imaging for Blood Diseases
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Sexuality, Behavior, and Technology
- Urological Disorders and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Cancer Cells and Metastasis
- Advanced Glycation End Products research
- Advanced X-ray and CT Imaging
- Diversity and Career in Medicine
- Marriage and Sexual Relationships
- Medical Imaging Techniques and Applications
- Healthcare cost, quality, practices
- COVID-19 diagnosis using AI
- Medication Adherence and Compliance
- Breast Cancer Treatment Studies
Case Western Reserve University
2015-2023
University School
2018-2023
University Hospitals of Cleveland
2018-2020
University Hospitals Cleveland Medical Center
2019
Case Comprehensive Cancer Center
2019
Abstract The tumor immune composition influences prognosis and treatment sensitivity in lung cancer. presence of effective adaptive responses is associated with increased clinical benefit after checkpoint blockers. Conversely, immunotherapy resistance can occur as a consequence local T-cell exhaustion/dysfunction upregulation immunosuppressive signals regulatory cells. Consequently, merely measuring the amount tumor-infiltrating lymphocytes (TILs) may not accurately reflect complexity...
BackgroundWe developed and validated an integrated radiomic-clinicopathologic nomogram (RadClip) for post-surgical biochemical recurrence free survival (bRFS) adverse pathology (AP) prediction in men with prostate cancer (PCa). RadClip was further compared against extant prognostics tools like CAPRA Decipher.MethodsA retrospective study of 198 patients PCa from four institutions who underwent pre-operative 3 Tesla MRI followed by radical prostatectomy, between 2009 2017 a median 35-month...
Abstract Background Human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) has excellent control rates compared to nonvirally associated OPSCC. Multiple trials are actively testing whether de-escalation of treatment intensity for these patients can maintain oncologic equipoise while reducing treatment-related toxicity. We have developed OP-TIL, a biomarker that characterizes the spatial interplay between tumor-infiltrating lymphocytes (TILs) and surrounding cells...
Prognostic markers currently utilized in clinical practice for estrogen receptor-positive (ER+) and lymph node-negative (LN-) invasive breast cancer (IBC) patients include the Nottingham grading system Oncotype Dx (ODx). However, these biomarkers are not always optimal remain subject to inter-/intra-observer variability high cost. In this study, we evaluated association between computationally derived image features from H&E images disease-free survival (DFS) ER+ LN- IBC. a total of n = 321...
BACKGROUND. In-gantry MRI-guided biopsy (MRGB) of the prostate has been shown to be more accurate than other targeted methods. However, optimal number cores obtain during in-gantry MRGB remains undetermined. OBJECTIVE. The purpose this study was assess diagnostic yield obtaining an incremental from primary lesion and second sampling prostate. METHODS. This retrospective included 128 men with 163 lesions who underwent between 2016 2019. had a total sampled two or cores, 121 three 52 four...
around one third of clinically significant prostate cancer (CsPCa) foci are reported to be MRI non-visible (MRI─).To quantify the differences between MR visible (MRI+) and MRI─ CsPCa using intra- peri-lesional radiomic features on bi-parametric (bpMRI).This retrospective multi-institutional study comprised 164 patients with pre-biopsy 3T multi-parametric from 2014 2017. The referred lesions PI-RADS v2 score < 3 but ISUP grade group > 1. Three experienced radiologists were involved in...
Abstract Background Accurate delineations of regions interest (ROIs) on multi‐parametric magnetic resonance imaging (mpMRI) are crucial for development automated, machine learning‐based prostate cancer (PCa) detection and segmentation models. However, manual ROI labor‐intensive susceptible to inter‐reader variability. Histopathology images from radical prostatectomy (RP) represent the “gold standard” in terms delineation disease extents, example, PCa, prostatitis, benign prostatic...
Purpose: We used computerized image analysis and machine learning approaches to characterize spatial arrangement features of the immune response from digitized autopsied H&E tissue images lung in coronavirus disease 2019 (COVID-19) patients. Additionally, we applied our approach tease out potential morphometric differences autopsies patients who succumbed COVID-19 versus H1N1. Approach: whole slide autopsy specimens nine two H1N1 were computationally interrogated. 606 patches (∼55 per...
To measure the cost expenditure associated with renal cyst surveillance, we examined surveillance patterns at our institution and surplus of unindicated imaging.Patients a diagnosis between January 2017 June 2018 were identified their respective clinical imaging data reviewed for patterns. Unindicated followup was defined by Radiographic Society North America Canadian Urological Association. Total unnecessary expenditures from ultrasound, computerized tomography magnetic resonance calculated...
You have accessJournal of UrologyProstate Cancer: Detection & Screening VI1 Apr 2018MP77-02 A NEW VERSUS AN OLD NOTION: IS THERE ANY CORRELATION BETWEEN MULTI-PARAMETRIC MRI (MPMRI) PI-RADS (PROSTATE IMAGING-REPORTING AND DATA SYSTEM) SCORE PSA SPECIFIC ANTIGEN) KINETICS? Zhina Sadeghi, Rayan Abboud, Bissan Amr Mahran, Christina Buzzy, Julia Yang, Vikas Gulani, and Lee Ponsky SadeghiZhina Sadeghi More articles by this author , AbboudRayan Abboud AbboudBissan MahranAmr Mahran BuzzyChristina...
You have accessJournal of UrologyGeneral & Epidemiological Trends Socioeconomics: Advanced Practice Providers (PD16)1 Apr 2019PD16-08 COST SAVINGS ANALYSIS OF INPATIENT ADVANCED PRACTICE PROVIDER Mitchell Ng, BS Michael Wang, Laura Bukavina, MD MPH* Amr Mahran, MS Kirtishri Mishra, Callagari, MBA Christina Buzzy, andPhD Lee PonskyMD NgMitchell Ng More articles by this author , WangMichael Wang BukavinaLaura Bukavina MahranAmr Mahran MishraKirtishri Mishra CallagariMichael Callagari...
You have accessJournal of UrologyProstate Cancer: Detection & Screening V1 Apr 2018MP57-17 CAN PROSTATIC SPECIFIC ANTIGEN VELOCITY (PSAV) IMPROVE THE DIAGNOSTIC ACCURACY OF PROSTATE IMAGING REPORTING AND DATA SYSTEM (PI-RADS) SCORE FOR PREDICTING SIGNIFICANT CANCER Amr Mahran, MD, Johnny Su, Christina Buzzy, PhD, Julia Yang, MS, Vikas Gulani, and Lee Ponsky, MD MDAmr More articles by this author , SuJohnny Su PhDChristina PhD MSJulia MS MDVikas MDLee View All Author...
You have accessJournal of UrologyImaging/Radiology: Uroradiology I (PD23)1 Apr 2019PD23-02 THE EFFECTS OF ANDROGEN DEPRIVATION THERAPY ON BRAIN VOLUME 3D PLANIMETRY Nishant Jain, BS Laura Bukavina, MD MPH* Kirtishri Mishra, Amr Mahran, MS Christopher Kondray, David Sheyn, Christina Buzzy, PhD Lee Ponsky, Kristina Garrels, andMD Carvell NguyenMD JainNishant Jain More articles by this author , BukavinaLaura Bukavina MishraKirtishri Mishra MahranAmr Mahran KondrayChristopher Kondray SheynDavid...
You have accessJournal of UrologyGeneral & Epidemiological Trends Socioeconomics: Quality Improvement Patient Safety I (MP10)1 Apr 2019MP10-11 PAIN MANAGEMENT IN OUTPATIENT UROLOGIC PROCEDURES – A PROSPECTIVE RANDOMIZED TRIAL OF OXYCODONE VERSUS KETOROLAC Kirtishri Mishra*, Melody Chen, Laura Bukavina, Amr Mahran, Jonathan Kiechle, Michael Wang, Christina Buzzy, Lee Ponsky, and Christopher Gonzalez Mishra*Kirtishri Mishra* More articles by this author , ChenMelody Chen BukavinaLaura Bukavina...