A5064274343- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Liver physiology and pathology
- Bioinformatics and Genomic Networks
- Ferroptosis and cancer prognosis
- Hedgehog Signaling Pathway Studies
- Thyroid Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Thyroid and Parathyroid Surgery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Parathyroid Disorders and Treatments
Cleveland Clinic
2019-2024
Fox Chase Cancer Center
2013-2019
Drexel University
2013-2019
Ontario Institute for Cancer Research
2012-2013
University of Toronto
2013
Ludwig-Maximilians-Universität München
2009
Heinrich Heine University Düsseldorf
2009
Luisenkrankenhaus
2009
Charité - Universitätsmedizin Berlin
2009
Significance The evolutionarily conserved RNA-binding protein Musashi-2 (MSI2) regulates mRNA translation and influences multiple biological processes, including maintenance of stem cell identity. This work for the first time, to our knowledge, identifies that more aggressive patient tumors have higher MSI2 levels. We define a critical role in supporting non-small lung cancer (NSCLC) invasiveness further claudins 3, 5, 7 (CLDN3, CLDN5, CLDN7), TGF-β receptor 1 (TGFβR1), small mothers against...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide frequently impervious to curative treatment efforts. Similar other cancers associated with prolonged exposure carcinogens, HNSCCs often have a high burden of mutations, contributing substantial inter- intra-tumor heterogeneity. The heterogeneity this malignancy further increased by rising rate human papillomavirus (HPV)-associated (HPV+) HNSCC, which defines an etiological subtype significantly different...
Anti-Müllerian hormone (AMH) and its type II receptor AMHR2, both previously thought to primarily function in gonadal tissue, were unexpectedly identified as potent regulators of transforming growth factor (TGF-β)/bone morphogenetic protein (BMP) signaling epithelial-mesenchymal transition (EMT) lung cancer. AMH is a TGF-β/BMP superfamily member, AMHR2 heterodimerizes with I receptors (ALK2, ALK3) also used by the for BMP (BMPR2). regulates expression BMPR2, ALK2, ALK3, supports kinase...
Clinical decision making for human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is predominantly guided by disease stage anatomic location, with few validated biomarkers. The epidermal growth factor receptor (EGFR) an important therapeutic target, but its value in guiding remains ambiguous. We integrated analysis of clinically annotated tissue microarrays data available through the TCGA, to investigate idea that expression signatures involving EGFR, proteins...
No treatment strategies effectively limit the progression of Alzheimer's disease (AD), a common and debilitating neurodegenerative disorder.The absence viable options reflects fact that pathophysiology genotypic causes are not well understood.The advent genome-wide association studies (GWAS) has made it possible to broadly investigate alterations driving phenotypic occurrences.Recent have associated single nucleotide polymorphisms (SNPs) in two paralogous scaffolding proteins, NEDD9 CASS4,...
Circulating tumor cells (CTC) and plasma cell-free RNA (cfRNA) can serve as biomarkers for prognosis treatment response in lung cancer. One barrier to the selected or routine use of CTCs cfRNA precision oncology is limited quantity both, are only seen metastatic disease. As capture presents an opportunity monitor assess malignancies without invasive procedures, we compared two methods CTC identification, profiled mRNA from identify potential tumor-associated biomarkers. Peripheral blood was...
// Tim N. Beck 1,4,* , John Kaczmar 1,2,* Elizabeth Handorf 1 Anna Nikonova Cara Dubyk Suraj Peri Miriam Lango 3 A. Ridge Ilya G. Serebriiskii 1,6 Barbara Burtness 5 Erica Golemis 1,4 and Ranee Mehra 1,2 Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, USA 2 Medical Oncology, Surgical 4 Cell Biology Genetics, Drexel University College of Medicine, Department Internal Yale School Medicine New Haven, CT, 6 Biochemistry, Kazan Federal University, Kazan, Russia * These authors...
Copy number variations (CNVs) are a major source of genomic variability and especially significant in cancer. Until recently microarray technologies have been used to characterize CNVs genomes. However, advances next-generation sequencing technology offer opportunities deduce copy directly from genome data. Unfortunately cancer genomes differ normal several aspects that make them far less amenable detection. For example, often aneuploid an admixture diploid/non-tumor cell fractions. Also...
Immune checkpoint inhibitors (ICIs) have emerged as paradigm shifting treatment options for a number of cancers. Six antibodies targeting the immune proteins programmed cell death 1 (PD-1), ligand (PD-L1) or cytotoxic T-lymphocyte associated protein 4 (CTLA4) been approved. In some cases, response rates impressive, but not uniformly so and consistently; similarly, toxicity to this class therapeutic is often unpredictable can be life threatening. Predicting are two main obstacles truly...
// Anna V. Gaponova 1, 2 , Alexander Y. Deneka Tim N. Beck 3 Hanqing Liu 4 Gregory Andrianov S. Nikonova 1 Emmanuelle Nicolas Margret B. Einarson Erica A. Golemis Ilya G. Serebriiskii Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA Department of Biochemistry and Biotechnology, Kazan Federal University, 420008, Russian Federation & Biology, Program in Cell Biology Genetics, Drexel University College Medicine, 19129, Pharmaceutics, Jiangsu School Pharmacy, Jingkou...
Hemolytic transfusion reactions and transfusion-related acute lung injury (TRALI) are life-threatening complications associated with the of blood products. Hemorrhage is one most common surgical risk bleeding particularly in patients hematologic deficiencies. Management can be divided into two phases. The first phase centers on immediate control second focuses keeping patient stable reducing sequelae transfusions loss. We present case a 53-year-old woman long-standing immune thrombocytopenia...
11027 Background: Some recent publications indicated that the use of G-CSF could be connected to an increase in CTC as well elevated levels tumor markers such CA 27.29. In SUCCESS Trial and CA27.29 are examined before after adjuvant chemotherapy (CHT) 3754 breast cancer patients (pts). Methods: The is a phase III trial comparing FEC-Docetaxel vs. FEC-Doc-Gemcitabine regime 2 5 years treatment with zoledronate primary (BC) (N+ or high risk). Blood samples taken CHT. were assessed...