A5080742016- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Retinal Diseases and Treatments
- Bone Tumor Diagnosis and Treatments
- Tracheal and airway disorders
- Retinoids in leukemia and cellular processes
- NF-κB Signaling Pathways
- Protease and Inhibitor Mechanisms
- Cancer-related gene regulation
- Ear and Head Tumors
- Oral and Maxillofacial Pathology
University of Alabama at Birmingham
2022-2025
Rationale: Developing novel pre-operative and intraoperative imaging approaches for glioblastoma multiforme (GBM) could aid therapeutic intervention while sparing healthy normal brain, which remains a significant clinical challenge. 5-aminolevulinic acid (5-ALA) is the only agent approved to resection of GBM. Matrix metalloproteinase 14 (MMP14), overexpressed in GBM, an attractive target preoperative Prior studies have shown feasibility near-infrared fluorescence (NIRF) positron emission...
Abstract Purpose: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has continually increased during the past several decades. Using transoral robotic surgery (TORS) significantly improves functional outcomes relative to open for OPSCC. However, TORS limits tactile feedback, which is often most important element cancer surgery. Fluorescence-guided (FGS) strategies aid surgeon assessment malignancy resection are in various phases clinical research but exhibit greatest potential...
Transoral laser microsurgery represents the primary surgical modality for early laryngeal cancers with oncologic outcomes equivalent to radiotherapy. Accurate tumor mapping and margin assessment can be difficult, however, particularly during piecemeal or ablative resections, tumors a wider geographic footprint. Tumor‐targeted fluorescence‐guided surgery in patients head neck cancer has empirically improved identification; this case details, first time, resection of T2N0M0 transglottic using...
Abstract Accurate assessment of tumor margins with specific, non-invasive imaging would result in the preservation healthy tissue and improve long-term local control, thereby reducing risk recurrence. Overexpression epidermal growth factor receptor (EGFR) has been used other cancers as an biomarker to identify cancerous tissue. We hypothesize that expression EGFR ameloblastomas may be specifically visualize tumors. The aims this study are measure specificity radiolabeled 89 Zr-panitumumab...
<p>Supplementary Figure S2: Additional characterization of bipolar forceps instrument and normal tissue fluorescence signals without the tumor in view.</p>
<p>Supplementary Video S1: Late-resection intraoperative brightfield and robot fluorescence views of representative OPSCC cases.</p>
<div>AbstractPurpose:<p>The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has continually increased during the past several decades. Using transoral robotic surgery (TORS) significantly improves functional outcomes relative to open for OPSCC. However, TORS limits tactile feedback, which is often most important element cancer surgery. Fluorescence-guided (FGS) strategies aid surgeon assessment malignancy resection are in various phases clinical research but exhibit...
<p>Supplementary Video S2: Locating missed OPSCC fragment using intraoperative robot fluorescence.</p>
<p>Supplementary Figure S1: OPSCC EGFR H-scores.</p>
<p>Supplementary Video S1: Late-resection intraoperative brightfield and robot fluorescence views of representative OPSCC cases.</p>
<p>Supplementary Figure S1: OPSCC EGFR H-scores.</p>
<p>Supplementary Figure S3: Additional characterization of consecutive OPSCC presentations in a single patient.</p>
<div>AbstractPurpose:<p>The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has continually increased during the past several decades. Using transoral robotic surgery (TORS) significantly improves functional outcomes relative to open for OPSCC. However, TORS limits tactile feedback, which is often most important element cancer surgery. Fluorescence-guided (FGS) strategies aid surgeon assessment malignancy resection are in various phases clinical research but exhibit...
<p>Supplementary Figure S2: Additional characterization of bipolar forceps instrument and normal tissue fluorescence signals without the tumor in view.</p>
<p>Supplementary Video S2: Locating missed OPSCC fragment using intraoperative robot fluorescence.</p>
<p>Supplementary Figure S3: Additional characterization of consecutive OPSCC presentations in a single patient.</p>
Context.— Tumor contaminants were incidentally noted in frozen section margins of oropharyngeal squamous cell carcinoma. Objective.— To estimate the frequency tumor slides patients who underwent surgery for pharyngeal cancer, and to characterize surgical pathologic context these incidents. Design.— A retrospective search was conducted identify resections from 2016 2022. Surgical pathology, operative reports, reviewed. Preanalytical phase defined as that occurred with or without occurrence...