A5029990715- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Dendrimers and Hyperbranched Polymers
- Advanced Nanomaterials in Catalysis
- Polymer Surface Interaction Studies
- Photodynamic Therapy Research Studies
- Molecular Sensors and Ion Detection
- Reproductive tract infections research
- Pancreatic function and diabetes
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Pediatric health and respiratory diseases
- Graphene and Nanomaterials Applications
- Clostridium difficile and Clostridium perfringens research
- Cancer Research and Treatments
- Microbial Metabolites in Food Biotechnology
- Cervical Cancer and HPV Research
- Diabetes and associated disorders
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Eosinophilic Esophagitis
- Microscopic Colitis
- Food Allergy and Anaphylaxis Research
Zhejiang University
2025
Jinhua Academy of Agricultural Sciences
2025
University of Michigan
2021-2024
BioSurfaces (United States)
2024
Southwest Jiaotong University
2017-2021
Ministry of Education Science and Technology
2018
Chengdu University
2018
Abstract The complex tumor microenvironment constitutes a variety of barriers to prevent nanoparticles (NPs) delivery and results in extremely low accumulation nanomedicines solid tumors. Here, newly developed size‐changeable collagenase‐modified polymer micelle is employed enhance the penetration retention nanomedicine deep tissue. TCPPB first formed by self‐assembly maleimide‐terminated poly(ethylene glycol)‐ block ‐poly(β‐amino ester) (MAL‐PEG‐PBAE) succinic anhydride‐modified...
Tumor hypoxia and the short half-life of reactive oxygen species (ROS) with small diffusion distance have greatly limited therapeutic effect photodynamic therapy (PDT). Here, a multifunctional nanoplatform is developed to enhance PDT through increasing concentration in tumor cells by Fenton reaction reducing between ROS target site mitochondrial targeting. Fe3O4@Dex-TPP nanoparticles are first prepared coprecipitation presence triphenylphosphine (TPP)-grafted dextran (Dex-TPP) Fe2+/Fe3+,...
The cGAS-STING pathway plays a crucial role in innate immune activation against cancer and infections, STING agonists based on cyclic dinucleotides (CDN) have garnered attention for their potential use immunotherapy vaccines. However, the limited drug-like properties of CDN necessitate an efficient delivery system to system. To address these challenges, we developed immunostimulatory agonists. Here, examined aqueous coordination interactions between metal ions report that mixed with Zn2+...
Abstract Mitochondrial‐targeting therapy is an emerging strategy for enhanced cancer treatment. In the present study, a multistage targeting using doxorubicin‐loaded magnetic composite nanoparticles developed efficacy of photothermal and chemical therapy. The with core–shell–SS–shell architecture are composed core Fe 3 O 4 colloidal nanocrystal clusters, inner shell polydopamine (PDA) functionalized triphenylphosphonium (TPP), outer methoxy poly(ethylene glycol) linked to PDA by disulfide...
The checkpoint inhibitor therapy that blocks programmed death-1 (PD-1) and its major ligand PD-L1 has achieved encouraging clinical efficacy in certain cancers. However, the binding of inhibitors with other immune cells express often results a low response rate to blockade severe adverse effects. Herein, an LyP1 polypeptide-modified outer-membrane vesicle (LOMV) loaded PD-1 plasmid is developed achieve self-blockade tumor cells. nanocarriers accumulate tissue through OMV-targeting ability...
A dual drug–loaded, pH-responsive polymersome can induce endoplasmic reticulum (ER) stress and autophagy blockade in cancer cells.
Abstract Peptides, which are made up of amino acids, an excellent candidate as a composition component nanocarrier for drug delivery due to their biocompatibility, bioavailability, and stability in vivo. Here, the progress peptides nanocarriers applications cancer therapy summarized, including matrix self‐assembled nanoparticles, surface modification moieties targeting and/or penetrating function, enzyme‐responsive linkers nanoparticles triggering release. Peptide‐based should receive more...
Type 1 diabetes (T1D) is an autoimmune disorder in which pancreatic β-cells are destroyed by CD8+ T cells. Anti-CD3 antibody effectively treats early-stage T1D when β-cell autoantibodies detected but before symptoms appear. However, it impairs the immune system temporarily, exposing individuals to infection. A therapeutic that can reverse new-onset without harming remains urgently needed. Herein, we have constructed cellular vesicles presenting granzyme B-responsive fusion proteins...
Abstract Injectable formulations with sustained and steady release capabilities are critically required to treat diseases requiring temporary or lifelong continuous therapy, especially for drugs a short half‐life. Additionally, achieving sufficiently high drug loading in single dose remains persistent challenge. Herein, by mimicking the formation principles of mussel adhesive plaques, we have developed membrane‐enclosed crystalline systems insulin progesterone as model macro‐ small‐molecular...
Abstract Injectable formulations with sustained and steady release capabilities are critically required to treat diseases requiring temporary or lifelong continuous therapy, especially for drugs a short half‐life. Additionally, achieving sufficiently high drug loading in single dose remains persistent challenge. Herein, by mimicking the formation principles of mussel adhesive plaques, we have developed membrane‐enclosed crystalline systems insulin progesterone as model macro‐ small‐molecular...
Abstract The accumulation of nanoparticles in tumors by the enhanced permeability and retention (EPR) effect is effective well known. However, how to maximize still a bottleneck development nanomedicine. Herein, tumor vascular‐targeted hybrid polymeric micelle, which has great capacity selectively augment EPR dilating blood vessels via activity nitric oxide (NO), presented. Under neutral conditions, micelle stable, with long circulation half‐life due carboxylated poly(ethylene glycol) (PEG)...
A dual-targeted cascade-responsive multifunctional micelle is fabricated, which can carry the therapeutic agent into mitochondrion to induce mitochondrial apoptosis.
<h3>Background</h3> Immune checkpoint blockers (ICBs) have been a breakthrough for cancer treatment. However, ICBs benefit only subset of patients and can cause immune-related adverse events (irAEs).<sup>1</sup> In particular, recent studies identified correlation between dysregulated gut microbiomes poor clinical outcomes with ICBs, as well increased risks immunotherapy-induced colitis.<sup>2</sup> Toward the goals microbiome modulation potentiating ICB treatment, we developed an oral gel...
<h3>Background</h3> The dysregulated gut microbiota found in cancer patients is emerging as the new therapeutic target. Here, we have engineered inulin – a widely consumed dietary fiber into an oral gel formulation to modulate and host immune responses. We show that improves safety anti-tumor efficacy of checkpoint blockers (ICBs) various murine tumor models. <h3>Methods</h3> optimized scale-up production gel. In tumor-bearing mice, was orally administered starting day 7 after inoculation,...
Objective To investigate the value of ultrasonography in diagnosing benign and malignant thyroid nodules.Methods The data 60 patients with 81 nodules were retrospectively observed analyzed,including size,shape,border,echoes,crocalcification blood signal.Results ultrasound findings ill-defined edge,irregular shape,A/T ≥ 1,hypoechogenicity,microcalcification rich flow.Conclusion plays an important role nodules. Key words: Thyroid nodule; Ultrasonography; Diagnosis
Objective : In order to increase the survival rate of clinical thumb reconstruction, Doppler ultrasound (DU) imaging technology based on minimum variance adaptive beamforming (MV) algorithm is applied preoperative examination reconstruction. Method 75 patients who needed reconstruction were divided into 40 study group and 35 traditional group. Before operation, color was used examine saphenous vein, radial artery in receiving area, dorsalis pedis cephalic vein donor area determine whether...