A5102451460- Aquaculture disease management and microbiota
- RNA Interference and Gene Delivery
- Reproductive biology and impacts on aquatic species
- Bioinformatics and Genomic Networks
- Plant Stress Responses and Tolerance
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related gene regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Plant responses to water stress
- Inflammasome and immune disorders
- Lipid metabolism and biosynthesis
- interferon and immune responses
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Gene expression and cancer classification
- Eicosanoids and Hypertension Pharmacology
- Invertebrate Immune Response Mechanisms
- Animal Virus Infections Studies
- Cerebrovascular and Carotid Artery Diseases
- Ubiquitin and proteasome pathways
Guangxi Medical University
2024-2025
Nanchang University
2024
Jiangxi University of Traditional Chinese Medicine
2024
University of New Hampshire
2024
Chinese Academy of Fishery Sciences
2023-2024
Zhejiang Ocean University
2023-2024
University of Electronic Science and Technology of China
2024
Jilin Academy of Agricultural Sciences
2024
Animal Science Research Institute
2024
University of New Hampshire at Manchester
2023
As a typical E3 ligase, TRIM65 (tripartite motif containing 65) is involved in the regulation of antiviral innate immunity and pathogenesis certain tumors. However, role renal cell carcinoma (RCC) underlying mechanism has not been determined yet. In this study, we identified as novel oncogene RCC, which enhanced tumor proliferation anchorage-independent growth abilities both vitro vivo. Moreover, found that TRIM65-regulated RCC mainly via direct interaction with BTG3 (BTG anti-proliferation...
Hepatocellular carcinoma (HCC) is a global health concern, ranking as the fourth leading cause of cancer-related deaths worldwide. However, role piwi-interacting RNAs (piRNAs) in HCC processes has not been extensively explored. Through small RNA sequencing, our study identified specific piRNA, pir-hsa-216911, which highly expressed cells. This overexpression pir-hsa-216911 promotes cell invasion and inhibits death, particularly pyroptosis. Knocking out led to increased pyroptosis activity,...
Abstract Background Chronic cerebral hypoperfusion (CCH) is a frequently encountered clinical condition that poses diagnostic challenge due to its nonspecific symptoms. Purpose To enhance the diagnosis of CCH and non‐CCH through Magnetic Resonance Imaging (MRI), offering support in decision‐making recommendations ultimately elevate accuracy optimize patient treatment outcomes. Methods In retrospective research, we collected 204 routine brain magnetic resonance imaging (MRI) from March 1...
Abstract Rice, an important food resource, is highly sensitive to salt stress, which directly related security. Although many studies have identified physiological mechanisms that confer tolerance the osmotic effects of salinity, link between rice genotype and not very clear yet. Association gene co‐expression network phenotypic data under stress has penitential identify stress‐responsive genes, but there no standard method associate phenotype with network. A novel for integration was...
Histone deacetylase 9 (HDAC9) is a histone (HDAC) subtype IIa protein that deacetylates 3 (H3), 4 (H4), and nonhistone proteins in vivo to alter chromosomal shape regulate gene transcription. There have been few studies on the regulatory influence of HDAC9 differentiation chicken embryonic stem cells (cESCs) into male germ cells, significance still unknown. Therefore, we explored specific role during cESCs Jilin Luhua chickens through inhibition or overexpression. In medium supplemented with...
Abstract Addressing the significant level of variability exhibited by pancreatic cancer necessitates adoption a systems biology approach that integrates molecular data, biological properties tumors, medical images, and clinical features patients. In this study, comprehensive multi-omics methodology was employed to examine distinctive collection patient dataset containing rapid autopsy tumor normal tissue samples as well longitudinal imaging with focus on cancer. By performing whole exome...
The sex chromosome, especially specific in one sex, generally determines sexual size dimorphism (SSD), a phenomenon with dimorphic difference the body size. For Cynoglossus semilaevis, flatfish China, although importance of chromosome W and its gene zbed1 female-biased SSD have been suggested, family members regulation information are still unknown. At present, three copies were identified on W, no gametologs. Phylogenetic analysis for ZBED revealed an existence ZBED9 fish. Nine uncovered...
Long nonconding RNAs (lncRNAs) have been found to be a vital regulatory factor in the development process of human cancer, and could regarded as diagnostic or prognostic biomarkers for cancers. Here, we aim confirm expression molecular mechanism RP11-171K16.5 (lnc171) hepatocellular carcinoma (HCC).
Abstract Addressing the significant level of variability exhibited by pancreatic cancer necessitates adoption a systems biology approach that integrates molecular data, biological properties tumors, and clinical features patients. In this study, comprehensive multi-omics methodology was employed to examine distinctive collection patient dataset containing rapid autopsy tumor normal tissue samples as well longitudinal imaging with focus on cancer. By performing whole exome sequencing analysis...
Abstract In many applications, such as gene co-expression network analyses, data arises with a huge number of covariates while the size sample is comparatively small. To improve accuracy prediction, variable selection often used to get sparse solution by forcing coefficients variables contributing less observed response zero. Various algorithms were developed for selection, but LASSO well known its statistical accuracy, computational feasibility and broad applicability adaptation. this...