A5074931746- HIV Research and Treatment
- Ion-surface interactions and analysis
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- Hydrogen embrittlement and corrosion behaviors in metals
- Corrosion Behavior and Inhibition
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Combustion and Detonation Processes
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pulsed Power Technology Applications
- Petroleum Processing and Analysis
- Integrated Circuits and Semiconductor Failure Analysis
- Fire dynamics and safety research
- Risk and Safety Analysis
- Drilling and Well Engineering
- Concrete Corrosion and Durability
- Diamond and Carbon-based Materials Research
- Energetic Materials and Combustion
- Metal and Thin Film Mechanics
- Cyclone Separators and Fluid Dynamics
- Vehicle emissions and performance
- Viral gastroenteritis research and epidemiology
- Orthopedic Infections and Treatments
Southwest Petroleum University
2018-2025
Alibaba Group (China)
2024
Harvard University
2015-2024
China Automotive Technology and Research Center
2021-2024
Beihang University
2018-2024
Dana-Farber Cancer Institute
2015-2024
Changzhou University
2024
Nanjing University of Science and Technology
2022-2023
Shanghai Ninth People's Hospital
2018-2023
Shanghai Jiao Tong University
2018-2023
Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can transmit more efficiently and partially evade protective immune responses, thus necessitating continued refinement antibody therapies immunogen design. Here, we elucidate structural basis mode action two potent SARS-CoV-2 spike (S)-neutralizing monoclonal antibodies, CV3-1 CV3-25, which remain effective against emerging in vitro vivo. binds to (485-GFN-487) loop within receptor-binding...
Esophageal squamous cell carcinoma is a major histological type of esophageal cancer, with distinct incidence and survival patterns among races. Although previous studies have characterized somatic mutations in this disease, rigorous comparison between different patient populations has not been conducted. Here we sequence the samples 316 Chinese patients, combine them those from The Cancer Genome Atlas, perform comparative analysis Asian Caucasian patients. We find that mutated CSMD3...
ABSTRACT The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer, which consists of the gp120 and gp41 subunits, is focus multiple strategies for vaccine development. Extensive Env glycosylation provides HIV-1 with protection from immune system, yet glycans are also essential components binding epitopes numerous broadly neutralizing antibodies. Recent studies have shown that when isolated virions, its profile differs significantly soluble forms (gp120 or gp140)...
The development of an effective and durable SARS-CoV-2 vaccine is essential for combating the growing COVID-19 pandemic. spike (S) glycoprotein main target neutralizing antibodies elicited during virus infection or following vaccination.
ABSTRACT HIV-1 envelope glycoprotein (Env) glycosylation is important because individual glycans are components of multiple broadly neutralizing antibody epitopes, while shielding other sites that might otherwise be immunogenic. The on Env influenced by a variety factors, including the genotype protein, cell line used for its expression, and details construct design. Here, we mass spectrometry (MS)-based approach to map complete profile at every site in trimers, accomplishing two goals. (i)...
In order to obtain propagation characteristics of a rotating detonation wave (RDW) cracked kerosene gas (CKG) and ambient temperature air, series experiments were carried out at different cracking air mass flow rates. The mode RDW was analyzed in detail, the ignition range CKG evaluated. experiment, modes mainly include single (SRDW) mode, reversed (RSRDW) mixed mode. SRDW two-counter alternate. Combined with high-speed photography pressure curve, mechanism transition is analyzed. RSRDW...
An experimental study on the auto-initiation process of rotating detonation waves (RDWs) was conducted with high-temperature hydrogen-rich gas as fuel and air oxidant. Spontaneous combustion occurred after they were injected into a chamber (RDC), which resulted in hot spots RDC induced formation deflagration flame. Then, an RDW formed through deflagration-to-detonation transition RDC. The mechanism RDWs studied detail experiments. influences equivalence ratio propagation characteristics...
The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in viral membrane to enter host cells. S is major target for neutralizing antibodies elicited by natural infection and vaccines. Approximately 35% consists carbohydrate, which can influence virus infectivity susceptibility antibody inhibition. We found that virus-like particles produced coexpression S, M, E, N proteins contained glycoproteins were extensively modified complex carbohydrates....
Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM have been shown to restrict viral infections regulate host cellular innate immune responses. In order identify modulate the infection hepatitis B virus (HBV), we tested 38 human TRIMs for their effects on HBV gene expression, capsid assembly DNA synthesis in hepatoma cells (HepG2). The study revealed ectopic expression 8 HepG2...
This paper develops an improved dynamic reliability model for compressor rotor system, defined as a "unconventional active system" here. First, regarding to the variety of system-component connections, system specific modeling technique is presented, in which stress and strength are both nonnegative stochastic processes. The new fully considers load characteristics blades, inherently embodied effect statistical dependence between failures blades. Then, calculated by model, relationship time,...
Objectives: To investigate the effects of inferior alveolar nerve on new bone formation in rabbit mandibular distraction osteogenesis.Methods: 20 New Zealand White rabbits underwent bilateral osteogenesis with a rate 1 mm/day.The one side was resected under surgical microscope, vascular intact.The contralateral received sham operation.The were sacrificed at consolidation time 28 days.The regenerate callus radiograph examination, dual-energy X-ray absorptiometry, haematoxylin and eosin...
The envelope glycoprotein (Env) spike on the surface of human immunodeficiency virus type 1 (HIV-1) mediates entry into host cells and is also target for antibodies. During entry, Env needs to change shape. flexibility contributes ability HIV-1 evade immune response; many shapes raise antibodies that cannot recognize functional therefore do not block infection. We found an inhibitor, BMS-806, stabilizes shape Env. developed new variants BMS-806 stabilize in its natural state long periods...
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer is transported through the secretory pathway to infected cell surface and onto virion particles. In Golgi, gp160 Env precursor modified by complex sugars proteolytically cleaved produce mature functional trimer, which resists antibody neutralization. We observed mostly uncleaved smaller amounts of gp120 gp41 Envs on HIV-1-infected or Env-expressing cells; however, were relatively enriched in virions virus-like...
Binding to the receptor, CD4, drives pretriggered, "closed" (state-1) conformation of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer into more "open" conformations (states 2 and 3). Broadly neutralizing antibodies, which are elicited inefficiently, mostly recognize state-1 Env conformation, whereas commonly poorly antibodies states 2/3. HIV-1 metastability has created challenges for defining structure developing immunogens mimicking this labile conformation....