A5037842087- Bacteriophages and microbial interactions
- HIV Research and Treatment
- RNA and protein synthesis mechanisms
- Pancreatic function and diabetes
- Wnt/β-catenin signaling in development and cancer
- Nerve injury and regeneration
- Microtubule and mitosis dynamics
- Neurogenesis and neuroplasticity mechanisms
- Liver physiology and pathology
- RNA Research and Splicing
- Aldose Reductase and Taurine
- Pluripotent Stem Cells Research
KU Leuven
2023-2024
Dana-Farber Cancer Institute
2022
Binding to the receptor, CD4, drives pretriggered, "closed" (state-1) conformation of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer into more "open" conformations (states 2 and 3). Broadly neutralizing antibodies, which are elicited inefficiently, mostly recognize state-1 Env conformation, whereas commonly poorly antibodies states 2/3. HIV-1 metastability has created challenges for defining structure developing immunogens mimicking this labile conformation....
Terminally differentiated cells are commonly regarded as the most stable cell state in adult organisms, characterized by growth arrest while fulfilling their specialized functions. A better understanding of mechanisms involved promoting cycle exit will improve ability to differentiate pluripotent into mature tissues for both pharmacological and therapeutic use. Here, it demonstrates that a hyperosmolar environment enforces protective p53-independent quiescent immature hepatoma stem...
ABSTRACT The efficacy of chemotherapy is often hindered by the enrichment a population cancer cells that enter drug-tolerant persister (DTP) state, mimicking embryonic diapause, yet underlying mechanisms this transition remain poorly understood. This study demonstrates both parental and chemotherapy-induced Wnt-active (Wnt High ) in Triple-negative breast exhibit transcriptional functional properties characteristic DTP cells, including diapause signature, reduced MYC expression, reversible...
ABSTRACT Binding to the receptor, CD4, drives pretriggered, “closed” (State-1) conformation of human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer into more “open” conformations (States 2 and 3). Broadly neutralizing antibodies, which are elicited inefficiently, mostly recognize State-1 Env conformation, whereas commonly poorly antibodies States 2/3. HIV-1 metastability has created challenges for defining structure developing immunogens mimicking this labile conformation....
ABSTRACT Terminally differentiated cells are regarded as the most stable and common cell state in adult organisms they reside growth arrest carry out their cellular function. Improving our understanding of mechanisms involved promoting cycle exit would facilitate ability to manipulate pluripotent into mature tissues for both pharmacological therapeutic use. Here, we demonstrated that a hyperosmolar environment enforced protective p53-independent quiescent dedifferentiated hepatoma stem...