A5063671736- Dermatology and Skin Diseases
- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Veterinary Oncology Research
- Exercise and Physiological Responses
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Urticaria and Related Conditions
- Veterinary Equine Medical Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Head and Neck Cancer Studies
- Immune Cell Function and Interaction
- Probiotics and Fermented Foods
- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Natural Compounds
- Infectious Diseases and Mycology
- Head and Neck Surgical Oncology
- Eosinophilic Disorders and Syndromes
- Cytokine Signaling Pathways and Interactions
- Contact Dermatitis and Allergies
- Platelet Disorders and Treatments
- IL-33, ST2, and ILC Pathways
- Nerve injury and regeneration
Tokyo University of Agriculture and Technology
2015-2024
Life Science Institute
2014-2024
International University of Health and Welfare
2024
Hiroshima University
2024
Research Organization of Information and Systems
2024
Tokyo Medical University
2022-2023
Tokyo Medical University Ibaraki Medical Center
2022-2023
Chiba Rosai Hospital
2023
Tokyo Medical University Hospital
2021-2022
Teikyo University Chiba Medical Center
2013
Four full-thickness skin wounds made in normal mice led to the significant increase levels of nerve growth factor (NGF) sera and wounded tissues. Since sialoadenectomy before inhibited rise serum NGF, NGF may be released from salivary gland into blood stream after wounds. In contrast, fact that messenger RNA protein were detected newly formed epithelial cells at edge wound fibroblasts consistent with granulation tissue produced space, suggests was also site. Topical application accelerated...
We examined in vivo efficiency of a gelatin film sheet with epidermal growth factor (EGF) for novel therapeutic device cutaneous wound repair. NIH3T3 fibroblasts and PAM212 keratinocytes proliferated when the cells were incubated homogenate EGF containing sheets, indicating that retained biologic activity process formation. To evaluate effects, sheets or control applied onto partial-thickness skin wounds made on dorsa hairless dogs. Wound closure treated was accelerated compared to...
Extracellular matrix-destructive enzymes, like matrix metalloproteinases (MMP), have been recognized in the process of inflammation and tissue remodeling repair. The affected tissues often contain markedly increased numbers mast cells. Although cells are capable activating latent collagenase proMMP, it has so far unknown whether human themselves produce secrete MMP9. In this study, MMP9 production by cord blood-derived cultured HMC-1 was examined reverse-transcriptase PCR, gelatin zymography...
Summary Background Continuous oral administration of live Lactobacillus rhamnosus GG ( L . GG) to pregnant subjects with atopic dermatitis and their children, suppressed the frequency dermatitis. The details mechanisms immune systems involved in this suppressive effect, however, remain speculative. Objective We sought clarify on by using NC/Nga mice, a model human Methods Maternal mice infant were fed food containing or not heat‐treated during pregnancy breastfeeding, after weaning. Results...
Since more than 75% of breast cancers overexpress estrogen receptors (ER), endocrine therapy targeting ER has significantly improved the survival rate. Nonetheless, cancer still afflicts women worldwide and major problem behind it is resistance to therapy. We have previously shown involvement nuclear factor-κB (NF-κB) in neoplastic proliferation human cells; however, association with transformation ER-positive cells remains unclear. In current study, we focused on roles NF-κB hormone...
Abstract Effect of nerve growth factor (NGF) on platelet-associated mast cell activation was investigated. Although neither NGF alone nor platelets induced significant 5-hydroxytriptamine (5-HT) release from rat peritoneal cells, marked 5-HT detected when costimulated with and calcium ionophore-activated platelets. This response reached maximal levels as early 5 min after the initiation coincubation completely blocked by anti-NGF Ab or an inhibitor for a tyrosine kinase trkA receptor....
Realization of a needle-free drug delivery device can solve needle-caused problems. Recently, attention has been given to the use focused liquid jet instead existing that generates turbulent jet. This study experimentally visualized penetration into gel and animal skin with very high speed around 200 m/s. We first examined high-speed images evaluate dynamics gel. found depth is determined within short time $$t_p$$ (on order 0.01 ms). similar $$L/V_j$$ , where L $$V_j$$ are, respectively,...
Motility and fertilizing ability are known to be two important physiological attributes of a mature sperm, yet the mechanism by which spermatozoa become motile remains largely unknown. It has been shown that nerve growth factor (NGF) is protein essential for development, maintenance survival peripheral central nervous systems. However, presence high levels NGF mRNA do not correlate with innervations sensitive fibers in tissues such as testis, prostate seminal vesicles. These observations...
Mast cells are one of the major producers prostaglandins (PGs). The final metabolite PGs 15-deoxy-delta-12,14-PGJ(2) (15-deoxy-delta PGJ(2)) is endogenous ligand peroxisome proliferator-activated receptor (PPAR) γ. PPARγ modulates adipocyte differentiation; therefore, we attempted to investigate whether derived from mast influenced on adipogenesis. We found increase cell numbers in fat tissue obese mice fed with a high-fat diet allowed us speculate contributions cell-mediated induction...
Constitutive nuclear factor-kappaB (NF-kappaB) activity plays a crucial role in the development and progression of lymphoma, leukemia, some epithelial cancers. Given contribution NF-kappaB carcinogenesis, novel approach that interferes with its might have therapeutic potential against cancers respond poorly to conventional treatments. Here, we shown new IkappaB kinase beta inhibitor, IMD-0354, suppressed growth human breast cancer cells, MDA-MB-231, HMC1-8, MCF-7, by arresting cell cycle...
Although the possible involvement of neurotrophic factors in itchy skins atopic dermatitis has been predicted, exact mechanism by which itch is induced remains unclear. Since nerve growth factor (NGF) crucial effects on development and functions sensory nerves, we determined production NGF extension fibers NC/NgaTnd mice with or without dermatitis. spontaneously develop dermatitis-like skin lesions when they are raised air-unregulated conventional circumstances. We quantified scratching...
Abstract: Prevalence of allergies has increased during the last two decades. Alteration gut microbiota composition is thought to play a crucial role in development atopic diseases. Oral administration probiotics been reported treat and/or prevent symptoms diseases infants, but results are still controversial. We investigated potential efficacy dietary interventions by probiotic strain on prevention and treatment dermatitis (AD) human‐like AD model, NC/NgaTnd mice perinatal administration....