A5028007643- Gut microbiota and health
- Infant Nutrition and Health
- Probiotics and Fermented Foods
- Pediatric health and respiratory diseases
- Infant Health and Development
- Dermatology and Skin Diseases
- Cancer Research and Treatments
- Digestive system and related health
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Clinical Nutrition and Gastroenterology
- Salmonella and Campylobacter epidemiology
- Parasitic Infections and Diagnostics
- Inflammatory Bowel Disease
- Fatty Acid Research and Health
- Advancements in Transdermal Drug Delivery
- Escherichia coli research studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Food Allergy and Anaphylaxis Research
- Herbal Medicine Research Studies
- Immune Response and Inflammation
- Microbial Metabolites in Food Biotechnology
- Enterobacteriaceae and Cronobacter Research
- Amoebic Infections and Treatments
Nestlé (France)
2025
Nestlé Health Science (United States)
2025
Nestlé (Switzerland)
2012-2024
Nestlé (Brazil)
2012-2014
University of Lausanne
2013
Institut Pasteur
2009
University Hospital of Lausanne
1997-2004
Centre Hospitalier Sainte-Anne
1981
OBJECTIVE. We examined the presence of a natural bacterial inoculum in breast milk and its intracellular transport from maternal intestine to through circulation. METHODS. Breast peripheral blood were collected aseptically healthy donors at various times after delivery, viable bacteria was determined plating. Temporal temperature gradient gel electrophoresis used examine ribosomal DNA content cells, mononuclear feces corresponding infant feces. Blood nongravid nonlactating women served as...
Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance commensal bacteria and a vigorous response pathogens. It has recently been demonstrated former involves limited migration bacterially loaded from Peyer's patches mesenteric lymph nodes. During lactation, gut-associated lymphoid tissue travel breast via lymphatics peripheral blood. Here, we show human blood mononuclear milk contain their genetic...
Attenuated strains of Salmonella are attractive live vaccine candidates for eliciting mucosal as well systemic immune responses. The ability to induce responses in the reproductive tract may be critical effectiveness a prophylactic against genital human papillomaviruses (HPV), which important etiologic agents development cervical cancer. To examine potential Salmonella-based prevent HPV infection, L1 major capsid protein from type 16 (HPV16) was constitutively expressed PhoPc strain...
ABSTRACT This study describes the in vivo activity of Lactobacillus johnsonii La1 (NCC533) Giardia intestinalis -infected gerbils ( Meriones unguiculatus ). Daily administration lactobacilli drinking water from 7 days before inoculation with trophozoites efficiently prevented G. strain WB clone C6 infecting gerbils. More specifically, shedding fecal antigens (GSA65 protein) was diminished La1-treated group, and resolution infection observed by 21 postinoculation. Histology analysis enzymatic...
Summary We evaluated whether a probiotic supplementation in dogs with food responsive diarrhoea (FRD) has beneficial effects on intestinal cytokine patterns and microbiota. Twenty‐one client‐owned FRD were presented for clinically needed duodeno‐ colonoscopy enrolled prospective placebo (PL)‐controlled trial. Intestinal tissue samples faeces collected during endoscopy. mRNA abundance of interleukin (IL)‐5, ‐10, ‐12p40 ‐13, tumour necrosis factor‐ α , transforming growth β 1 interferon (IFN)‐...
In recent decades, the prevalence of subjects with reactive skin has considerably increased in industrialised countries. 50% women and 30% men report cutaneous discomfort classified under reactive/sensitive skin. Several topical approaches have been proposed, particular through improvement galenic forms or protection epidermal surface. We propose to act differently, deeply from inside body via an innovative nutritional approach. To this purpose, Lactobacillus paracasei NCC 2461 (ST11) was...
Over the past few decades number of people presenting reactive skin has increased in industrial countries. Skin inflammation mediated by neuropeptides and impaired barrier function are both underlying features conditions. Live microorganisms defined as probiotics have been successfully used to improve health status humans. Beyond effects on intestinal microbiota, some probiotic strains display potent immune-modulatory properties at level. The aim this study was evaluate whether Lactobacillus...
The underlying biochemical consequences of inflammatory bowel disease (IBD) on the systemic and gastrointestinal metabolism have not yet been fully elucidated but could help to better understand pathogenesis identify tissue-specific markers associated with different stages. Here, we applied a metabonomic approach monitor metabolic events gradual development Crohn's (CD)-like ileitis in TNFΔARE/WT mouse model. Metabolic profiles intestinal compartments from age 4 up 24 weeks were generated by...
Bovine milk-derived oligosaccharides (MOS) containing primarily galacto-oligosaccharides with inherent concentrations of sialylated can be added to infant formula enhance the oligosaccharide profile.To investigate effects an MOS-supplemented on gut microbiota and intestinal immunity.In a double-blind, randomized, controlled trial, healthy term formula-fed infants aged 21-26 d either received intact protein cow milk-based (control group, CG, n = 112) or same 7.2 g MOS/L (experimental EG, 114)...
The precise mechanisms underlying the interaction between intestinal bacteria and host epithelium lead to multiple consequences that remain poorly understood at molecular level. Deciphering such events can provide valuable information as mode of action commensal probiotic microorganisms in gastrointestinal environment. Potential roles along privileged target represented by mucosal immune system include maturation prior, during after weaning, reduction inflammatory reactions pathogenic...
ABSTRACT Objectives: The aim of this study was to demonstrate the tolerance and safety an enteral formula containing prebiotics/probiotics, its effect on faecal microbiota in critically ill children. Subjects Methods: Ninety‐four patients between 1 3 years old under mechanical ventilation requiring feeding were randomised receive either a test synbiotic blend (composed 2 probiotic strains [ Lactobacillus paracasei NCC 2461 Bifidobacterium longum 3001], fructooligosaccharides [FOS], inulin,...
Wolfberry (fruit of Lycium barbarum) has been prized for many years in China its immunomodulatory property and high specific antioxidant content. However, clear clinical evidence demonstrating the effect wolfberry dietary supplementation is still lacking. After our earlier report showing that a proprietary milk-based formulation (Lacto-Wolfberry) enhances vivo antigen-specific adaptive immune responses aged mice, present study aimed at Lacto-Wolfberry on functions elderly, especially vaccine...
Post-natal gut maturation in infants interrelates of the morphology, digestive, and immunological functions microbiota development. Here, we explored both development markers barrier healthy term during their early life to assess interconnection different infant formulae regimes.A total 203 were enrolled this randomized double-blind controlled trial including a breastfed reference group. Infants fed starter for first four weeks life, supplemented with combination nutrients (lactoferrin,...