A5103948749- Pancreatic function and diabetes
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- interferon and immune responses
- Immune Response and Inflammation
- Diabetes Management and Research
- Diabetes and associated disorders
- Inflammasome and immune disorders
- Polyoxometalates: Synthesis and Applications
- MXene and MAX Phase Materials
- Genital Health and Disease
- Platelet Disorders and Treatments
- Renal and related cancers
- Biological and pharmacological studies of plants
- Genetics and Neurodevelopmental Disorders
- Identification and Quantification in Food
- Plant Stress Responses and Tolerance
- Cytokine Signaling Pathways and Interactions
- Metabolism, Diabetes, and Cancer
- Advanced battery technologies research
- Signaling Pathways in Disease
- Plant and animal studies
- Advanced Memory and Neural Computing
- Reliability and Maintenance Optimization
- Forest, Soil, and Plant Ecology in China
UCLouvain
2024-2025
Beihang University
2024
The Synergetic Innovation Center for Advanced Materials
2021
Nanjing Tech University
2021
Northeast Forestry University
2021
Genomics Institute of the Novartis Research Foundation
2015-2020
Center for Excellence in Molecular Cell Science
2017
University of Chinese Academy of Sciences
2017
University of Science and Technology of China
2015-2017
Yangzhou University
2016
Abstract Insufficient pancreatic β-cell mass or function results in diabetes mellitus. While significant progress has been made regulating insulin secretion from β-cells diabetic patients, no pharmacological agents have described that increase replication humans. Here we report aminopyrazine compounds stimulate robust proliferation adult primary islets, most likely as a result of combined inhibition DYRK1A and GSK3B. Aminopyrazine-treated human islets retain functionality vitro after...
Uncontrolled immune responses to intracellular DNA have been shown induce autoimmune diseases. Homeostasis regulation of cytosolic is critical for limiting the risk autoimmunity and survival host. Here, we report that E3 ubiquitin ligase tripartite motif protein 30α (TRIM30α) was induced by herpes simplex virus type 1 (HSV-1) infection in dendritic cells (DCs). Knockdown or genetic ablation TRIM30α augmented I IFNs interleukin-6 response viruses. Trim30α-deficient mice were more resistant...
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia diabetes. Thus, promoting proliferation could be one approach toward diabetes intervention. In this report we describe the discovery of potent selective DYRK1A inhibitor GNF2133, which was identified through optimization 6-azaindole screening hit. vitro, GNF2133 is able to proliferate both rodent human β-cells. vivo, demonstrated significant...
The nucleic acids of Mycobacterium tuberculosis can be detected by intracellular DNA sensors, such as cyclic GMP-AMP synthase and absent in melanoma 2 (AIM2), which results the release type I IFN proinflammatory cytokine IL-1β. However, whether cross-talk occurs between AIM2-IL-1β synthase-type signaling upon M. infection vivo is unclear. In this article, we demonstrate that mycobacterial AIM2-/- mice reciprocally induces overreactive IFN-β depressive IFN-γ responses, leading to higher...
Long-range aligned nanochannels are synthesized and utilized as Li + ion pathways in solid polymer electrolytes. Cyano groups distributed within accelerate migration, leading to superior ionic conductivity.
Toll‐like receptor 7 (TLR7) and TLR9 sense viral nucleic acids induce type I IFN production, which must be properly controlled to avoid autoimmune diseases. Here, we report the negative regulation of TLR7/9‐mediated production by TRIM35. TRIM35 expression is induced TLR7/9 stimulation then interacts with IRF7, master regulator response. Furthermore, promotes K48‐linked ubiquitination IRF7 induces its degradation via a proteasome‐dependent pathway. Therefore, feedback due ability suppress...
Abstract The emergence of solid‐state battery technology presents a potential solution to the dissolution challenges high‐capacity small molecule quinone redox systems. Nonetheless, successful integration argyrodite‐type Li 6 PS 5 Cl, most promising electrolyte system, and systems remains elusive due their inherent reactivity. Here, library derivatives is selected as model electrode materials ascertain critical descriptors governing (electro)chemical compatibility subsequently performances...
Platelet-rich plasma (PRP) is blood that has been enriched with platelets, and the number of platelets correlated rheumatoid activity. PRP a concentrated source autologous contains several different growth factors cytokines, including platelet‑derived factor, transforming factor‑β insulin‑like factor‑1, which stimulate healing bone soft tissue. Rheumatoid arthritis (RA) characterized by synovial hyperplasia, cell activation, articular inflammation invasion synovium into adjacent cartilage....
Loss of β-cell mass and function can lead to insufficient insulin levels ultimately hyperglycemia diabetes mellitus. The mainstream treatment approach involves regulation levels; however, approaches intended increase are less developed. Promoting proliferation with low-molecular-weight inhibitors dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential treat oral therapies by restoring mass, content glycemic control. GNF4877, a potent dual inhibitor DYRK1A glycogen...
Drought stress in trees limits their growth, survival, and productivity it negatively affects the afforestation survival rate. Our study focused on molecular responses to drought a coniferous species Larix olgensis A. Henry. was simulated one-year-old seedlings using 25% polyethylene glycol 6000. The response these assessed by analyzing select biochemical parameters, along with gene expression metabolite profiles. soluble protein content, peroxidase activity, malondialdehyde content of L ....
Pancreatic β-cell apoptosis, a hallmark of the development type 1 diabetes (T1D), is associated with increased levels pro-inflammatory cytokines. Thus, an agent protecting β-cells from cytokine-induced stress should have impact on maintaining functional mass in T1D. Screening ∼2 million-compound library identified series 7-azaindole derivatives as capable rat insulinoma death induced by The screening hits were optimized to result GNF3809, compound which preserves insulin content and...
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ABSTRACT Regeneration of the alveolar epithelium is necessary to restore tissue architecture and gas exchange capabilities in chronic pulmonary diseases such as fibrosing interstitial lung disease. While it known type 2 (AT2) cells give rise 1 (AT1) repair after injury, methods promote this process under pathological settings are poorly understood. Here, using a complex 3D organoid culture with TGF-β1 dependent impaired AT1 spheroid formation, we performed high-throughput screen (HTS)...
The reliability of the system is influenced by common cause failure mode and multi-state characteristic. This paper proposes an improved multi-value decision diagram method to analyze high-speed railway traction substation systems. According requirements safety-critical analysis, this begins with analysis structure unit module status, comprehensively considering influence failures characteristics. In paper, we design principle transforming fault tree model into a binary model. Fully...