A5006484881- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Gestational Diabetes Research and Management
- Health, Environment, Cognitive Aging
- Pregnancy and preeclampsia studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Child Nutrition and Water Access
- Physical Activity and Health
- Health disparities and outcomes
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Infant Nutrition and Health
- COVID-19 and healthcare impacts
- Genetic Associations and Epidemiology
- Childhood Cancer Survivors' Quality of Life
- Blood Pressure and Hypertension Studies
- Global Maternal and Child Health
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Poverty, Education, and Child Welfare
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Long-Term Effects of COVID-19
- Diabetes Management and Research
- Eating Disorders and Behaviors
University College London
2021-2025
Faculty (United Kingdom)
2023-2025
English Institute of Sport
2022-2025
American Chronic Pain Association
2021-2023
Leicester General Hospital
2021-2022
University of Leicester
2017-2022
Loughborough University
2015-2021
University of Bristol
2016-2017
University of Otago
2008
Background Individuals with obesity do not represent a homogeneous group in terms of cardiometabolic risk. Using 3 nationally representative British birth cohorts, we investigated whether the duration was related to heterogeneity Methods and findings We used harmonised body mass index (BMI) disease risk factor data from 20,746 participants (49.1% male 97.2% white British) enrolled cohort studies: 1946 National Survey Health Development (NSHD), 1958 Child Study (NCDS), 1970 Cohort (BCS70)....
Abstract Background Findings from studies assessing Long Covid in children and young people (CYP) need to be assessed light of their methodological limitations. For example, if non-response and/or attrition over time systematically differ by sub-groups CYP, findings could biased any generalisation limited. The present study aimed (i) construct survey weights for the Children with (CLoCk) study, (ii) apply them published CLoCk showing prevalence shortness breath tiredness increased baseline...
Chronic pain is highly prevalent and associated with a large burden of illness; there pressing need for safe, home-based, non-pharmacological, interventions. Virtual reality (VR) digital therapeutic known to be effective acute pain, but its role in chronic not yet fully elucidated. Here we present protocol the National Institute Health (NIH) Back Pain Consortium (BACPAC) VR trial that evaluates effectiveness three forms patients lower back (cLBP), form pain.The NIH BACPAC will randomise 360...
Abstract Objective Adults living with overweight or obesity do not represent a single homogenous group in terms of mortality and disease risks. The aim our study was to evaluate how the associations adulthood incident are modified by (i.e., differ according to) self-reported childhood body weight categories. Methods sample comprised 191,181 men 242,806 women aged 40–69 years (in 2006–2010) UK Biobank. outcomes were all-cause mortality, cardiovascular (CVD), obesity-related cancer. Cox...
Background The literature is equivocal as to whether the predicted negative mental health impact of COVID-19 pandemic came fruition. Some quantitative studies report increased emotional problems and depression; others improved well-being. Qualitative explorations reveal heterogeneity, with themes ranging from feelings loss growth development. Objective This study aims analyze free-text responses children young people participating in Children Young People With Long COVID get a clearer...
Objectives Construct updated birth weight-for-gestational age centile charts for use in the UK and compare these to currently used UK-WHO charts. Design Secondary analysis of national data. Participants Centiles were constructed using 1 269 403 singleton births occurring England Wales 2013–2014 as part MBRRACE-UK perinatal surveillance programme. These then validated 642 737 2015. Main outcome measures Sex-specific centiles. created lambda-mu-sigma method via GAMLSS package R. This...
Construct an ethnic-specific chart and compare the prediction of adverse outcomes using this with clinically recommended UK-WHO customised birth weight charts cut-offs for small-for-gestational age (SGA: <10th centile) large-for-gestational (LGA: >90th centile).Prospective cohort study.Born in Bradford (BiB) study, UK.3980 White British 4448 Pakistani infants complete data gestational age, weight, ethnicity, maternal height, parity.Prevalence SGA LGA, three indicators diagnostic utility...
In the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, chronic disabling fatigue lasting ≥6 months affected 1.3% 13-year-olds, was equally common in boys girls, became more prevalent with increasing family adversity.ALSPAC data were used to estimate prevalence syndrome (CFS) at age 16 years, defined by parental report unexplained months. We investigated gender a composite 14-item adversity index as risk factors. School absence obtained from National Pupil Database....
Background: Weight can be adjusted for height using the Benn parameter (kg/mB), where B is power that minimises correlation with height.Aim: To investigate how changes across age (10–65 years) and time (1956–2015) differs between sexes.Subjects methods: The sample comprised 49,717 individuals born in 1946, 1958, 1970 or 2001. Cross-sectional estimates of were produced cohort differences at ages 10/11 42/43 years examined linear regression. Multilevel modelling was used to develop...
Introduction Complex lipids are important constituents of the central nervous system. Studies have shown that supplementation with complex milk (CML) in pregnancy may increase level fetal gangliosides (GA), potential to improve cognitive outcomes. Methods and analysis We aim recruit approximately 1500 pregnant women first trimester (11–14 weeks) randomise them into one three treatment groups: standard maternal formulation, CML-enhanced formulation or no intervention advice (ie, care)....
Objective Little is known about persistence of or recovery from chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in adolescents. Previous studies have small sample sizes, short follow-up focused on rather than CFS/ME or, equivalently, fatigue, which disabling. This work aimed to describe the epidemiology and natural course adolescents aged 13–18 years. Design Longitudinal enrolled Avon Study Parents Children. Setting Avon, UK. Participants We identified who had disabling >6...
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Abstract Background There may be a bidirectional relationship between cognition and adiposity, whereby poor leads to increased adiposity vice versa. We aimed determine whether these findings are causal, by undertaking Mendelian randomization (MR) study. Methods A total of 378 877 UK Biobank participants had three indicators [body fat percentage (BF%), body mass index (BMI) waist-hip ratio] two cognitive function measures (reaction time, visual memory). examined observational associations...
Purpose: Loneliness is common amongst children and young people (CYP) an independent risk factor for poor health. This study aimed to i) determine whether subgroups of CYP with different loneliness trajectories (during the second year pandemic) exist; ii) examine associations socio-demographic characteristics subsequent health; iii) understand between health were modified by SARS-CoV-2 infection. Methods: A total 5851 (N=3260 positive 2591 negative) provided data on (via validated 3-item...
Abstract Background Body mass index (BMI) tracks from childhood-to-adulthood, but the extent to which this relationship varies across distribution and according socio-economic position (SEP) is unknown. We aimed address using data three British cohort studies. Methods used from: 1946 National Survey of Health Development (NSHD, n = 2470); 1958 Child Study (NCDS, 7747); 1970 Cohort (BCS, 5323). BMI tracking between 11 42 years was estimated quantile regression, with estimates reflecting...
Excess bodyweight (BMI >25 kg/m
Identify the prevalence of obesity in patients with chronic fatigue syndrome (CFS) compared healthy adolescents, and those identified CFS a population cohort.Cross-sectional analysis multiple imputed data.Data from UK paediatric CFS/myalgic encephalomyelitis (CFS/ME) services data collected at two time points Avon Longitudinal Study Parents Children (ALSPAC).1685 adolescents who attended CFS/ME specialist service between 2004 2014 13 978 aged approximately years 16 participating ALSPAC...
Although many studies have investigated the overlap between pain phenotypes and chronic fatigue syndrome (CFS) in adults, little is known about relationship these conditions adolescents. The study's aim was therefore to identify whether a exists widespread (CWP) CFS adolescents investigate two share common associations with set of covariates. A questionnaire administered offspring Avon Longitudinal Study Parents Children (ALSPAC) at age 17, asking site, duration, intensity, from which...
Objective Using a large national database of people hospitalised with COVID-19, we investigated the contribution cardio-metabolic conditions, multi-morbidity and ethnicity on risk in-hospital cardiovascular complications death. Methods A multicentre, prospective cohort study in 302 UK healthcare facilities adults COVID-19 between 6 February 2020 16 March 2021. Logistic models were used to explore associations baseline patient ethnicity, cardiometabolic conditions multimorbidity (0, 1, 2,...
OBJECTIVE To investigate the association between admission blood glucose levels and risk of in-hospital cardiovascular renal complications. RESEARCH DESIGN AND METHODS In this multicenter prospective study 36,269 adults hospitalized with COVID-19 6 February 2020 16 March 2021 (N = 143,266), logistic regression models were used to explore associations level (mmol/L mg/dL) odds complications, including heart failure, arrhythmia, cardiac ischemia, arrest, coagulation stroke, injury....