- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Body Composition Measurement Techniques
- Shoulder Injury and Treatment
- Health, Environment, Cognitive Aging
- Children's Physical and Motor Development
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- Bone health and osteoporosis research
- Birth, Development, and Health
- Nutrition and Health in Aging
- Lower Extremity Biomechanics and Pathologies
- Cardiac, Anesthesia and Surgical Outcomes
- Connective tissue disorders research
- Occupational Health and Performance
- Balance, Gait, and Falls Prevention
- Hip disorders and treatments
- Musculoskeletal pain and rehabilitation
- Ophthalmology and Visual Impairment Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone fractures and treatments
- Shoulder and Clavicle Injuries
- Knee injuries and reconstruction techniques
University of Bristol
2014-2024
Southmead Hospital
2011-2024
University of Warwick
2022
University Hospitals Bristol NHS Foundation Trust
2022
National Institute for Health Research
2022
University Hospitals Bristol and Weston NHS Foundation Trust
2022
Massey University
2021
NIHR Oxford Musculoskeletal Biomedical Research Centre
2016
Bristol Royal Hospital for Children
2013
University of the West of England
2013
<h3>Objective:</h3> To measure the levels and patterns of physical activity, using accelerometers, 11-year-old children participating in Avon Longitudinal Study Parents Children (ALSPAC). <h3>Design:</h3> Cross-sectional analysis. <h3>Setting:</h3> ALSPAC is a birth cohort study located former county Avon, southwest England. This used data collected when were 11 years old. <h3>Participants:</h3> 5595 (2662 boys, 2933 girls). The are offspring women recruited to during 1991–2. median age (95%...
Time spent in "sports/outdoor activity" has shown a negative association with incident myopia during childhood. We investigated the of time outdoors and physical activity separately.Participants Avon Longitudinal Study Parents Children (ALSPAC) were assessed by noncycloplegic autorefraction at ages 7, 10, 11, 12, 15 years, classified as myopic (≤-1 diopters) or emmetropic/hyperopic (≥-0.25 each visit (N = 4,837-7,747). Physical age 11 years was measured objectively using an accelerometer,...
Background: Objective methods can improve accuracy of physical activity measurement in field studies but uncertainties remain about their use. Methods: Children age 11 years from the Avon Longitudinal Study Parents and (ALSPAC), were asked to wear a uni-axial accelerometer (MTI Actigraph) for 7 days. Results: Of 7159 children who attended assessment, 5595 (78%) provided valid measures. The reliability coefficient 3 days recording was .7 power detect difference 0.07 SDs ( P ≤ .05) > 90%....
The aims of this study were to develop an equation predict energy expenditure and derive cut-points for moderate vigorous physical activity intensity from the Actigraph accelerometer output in children aged 12 years.The performed a series activities (lying, sitting, slow walking, fast hopscotch jogging) while wearing portable metabolic unit. sample was divided into developmental validation group. Random intercepts models used prediction assessed group by calculating limits agreement (actual...
<b>Objective</b> To investigate associations between physical activity at age 12 and subsequent adiposity 14. <b>Design</b> Prospective birth cohort study with data collected 2003 2007. <b>Setting</b> Original recruitment in 1991-2 of 14 541 pregnant women living the former County Avon (United Kingdom). <b>Participants</b> At 12, 11 952 children were invited to attend research clinic. Of these, 7159 attended, 4150 (1964 boys, 2186 girls) provided sufficient on exposure, outcome, confounding...
Although diagnostic criteria for generalized ligamentous laxity (hypermobility) in children are widely used, their validity may be limited, due to the lack of robust descriptive epidemiologic data on this condition. The present study was undertaken describe point prevalence and pattern hypermobility 14-year-old from a population-based cohort.We performed cross-sectional analysis using Avon Longitudinal Study Parents Children, large birth cohort. Hypermobility among cohort (mean age 13.8...
The pathological processes associated with development of cardiovascular disease begin early in life. For example, elevated blood pressure (BP) can be seen childhood and tracks into adulthood. relationship between physical activity (PA) BP adults is well-established, but findings children have been inconsistent, few studies measuring PA mechanically. Children aged 11 to 12 years were recruited from the Avon Longitudinal Study Parents Children. 5505 had systolic diastolic measurements, plus...
Summary Obesity is associated with the occurrence and severity of several musculoskeletal pain phenotypes, including knee chronic regional in adolescents. a risk factor for fibromyalgia adults, but whether similar relationship exists children uncertain. This study examined obesity reporting pain, (CRP) widespread (CWP), adolescents, population-based setting. A questionnaire was administered to offspring Avon Longitudinal Study Parents Children at age 17, asking about site, duration,...
To determine whether joint hypermobility (JH) in childhood is a risk factor for the subsequent development of musculoskeletal pain.JH was determined according to Beighton score at age 13.8 years children from Avon Longitudinal Study Parents and Children (ALSPAC), using cutoff ≥6 presence hypermobility. Musculoskeletal pain evaluated by questionnaire 17.8 years. Logistic regression analysis performed 2,901 participants (1,267 boys 1,634 girls) who had complete data.A total 4.6% JH Moderately...
<b>Objective</b> To examine factors in early life (up to age 5 years) that are associated with objectively measured physical activity 11-12 year olds. <b>Design</b> Prospective cohort study. <b>Setting</b> Avon longitudinal study of parents and children, United Kingdom. <b>Participants</b> Children aged years from the children. <b>Main outcome measure</b> Physical levels counts per minute (cpm) minutes moderate vigorous for seven days a uniaxial actigraph accelerometer. <b>Results</b> Valid...
Purpose: This study examined the seasonal and intraindividual variation in objectively measured physical activity 11- to 12-yr-olds. Methods: Children were asked wear a uniaxial accelerometer for 7 d four times throughout course of about year. A random-intercepts model was used separate inter- components activity. Gender, age, body mass index (BMI), height, month measurement fitted as potential confounders. Results: total 315 children had valid data at least two occasions, 244 all occasions....
Whether a certain level of impact needs to be exceeded for physical activity (PA) benefit bone accrual is currently unclear. To examine this question, we performed cross-sectional analysis between PA and hip BMD in 724 adolescents (292 boys, mean 17.7 years) from the Avon Longitudinal Study Parents Children (ALSPAC), partitioning outputs Newtest accelerometer into six different bands. Counts within 2.1 3.1g, 3.1 4.2g, 4.2 5.1g, >5.1g bands were positively related femoral neck (FN) BMD, boys...
The intensity of habitual physical activity (PA) needed to affect skeletal development in childhood is currently unclear.To examine associations between light PA, moderate and vigorous PA (as assessed by accelerometry), tibial cortical bone mass (BMC(C)) as measured peripheral quantitative computed tomography.Cross-sectional analysis based on the Avon Longitudinal Study Parents Children.A total 1748 boys girls (mean age 15.5 yr) participated study.We BMC(C), mineral density, periosteal...
This study assessed the effect of accelerometry-measured higher impacts resulting from habitual weight-bearing activity on lower limb bone strength in older women. Despite being experienced rarely this population-based cohort, positive associations were observed between vertical and size strength. We investigated whether benefit physical (PA) for women is explained by exposure to impacts, as previously suggested observations younger individuals. Four hundred eight Cohort Skeletal Health...
Background While the United Kingdom National Health Service aimed to reduce social inequalities in provision of joint replacement, it is unclear whether these gaps have reduced. We describe secular trends primary hip and knee replacement surgery between deprivation groups. Methods findings used Joint Registry identify all replacements performed for osteoarthritis from 2007 2017 England. The Index Multiple Deprivation (IMD) 2015 was relative level patient living area. Multilevel negative...
The COVID-19 pandemic has disrupted the provision of arthroplasty services in England, Wales, and Northern Ireland. This study aimed to quantify backlog, analyze national trends, predict time recovery.
Objective. Epidemiological studies have shown an association between OA and increased BMD. To explore the nature of this relationship, we examined whether risk is in individuals with high bone mass (HBM), whom BMD assumed to be elevated due a primary genetic cause.
Physical activity (PA) may need to produce high impacts be osteogenic. The aim of this study was identify threshold(s) for defining impact PA future analyses in the VIBE (Vertical Impact and Bone Elderly) study, based on home recordings with triaxial accelerometers. Recordings were obtained from 19 Master Athlete Cohort (MAC; mean 67.6 years) 15 Hertfordshire Study (HCS; 77.7 participants. Data cleaning protocols developed exclude artifacts. Accelerations expressed g units categorized into...
ABSTRACT The onset of walking in early childhood results exposure the lower limb to substantial forces from weight bearing activity that ultimately contribute adult bone strength. Relationships between gross motor score (GMS), at 18 months and outcomes measured age 17 years were examined 2327 participants Avon Longitudinal Study Parents Children (ALSPAC). Higher GMS indicated greater competence weight-bearing activities. Total hip mineral density (BMD) cross-sectional moment inertia (CSMI)...
To investigate the relative performance of knee replacement constructs compared with best performing construct and illustrate substantial variability in performance.A non-inferiority study.England Wales.All primary total unicondylar replacements performed registered National Joint Registry between 1 April 2003 31 December 2016.Kaplan-Meier failure function for constructs. Failure difference (the benchmark) other constructs.Using a analysis, by brand were construct. Construct was estimated...
Objectives: To investigate associations between objectively measured physical activity (PA) and myopia in children. Methods: Children from the Avon Longitudinal Study of Parents (ALSPAC) were asked to wear a uniaxial accelerometer for 7 days. Measures counts per minute (cpm), minutes spent moderate vigorous (MVPA) sedentary behaviour (msed) derived worn at age 12. also examined, 10, using an autorefractor estimate myopia. Social parental factors collected pregnancy measures child recorded...