A5026475470- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Vascular Malformations Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- Chemokine receptors and signaling
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Ziziphus Jujuba Studies and Applications
- Metabolism and Genetic Disorders
- PI3K/AKT/mTOR signaling in cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune cells in cancer
- Estrogen and related hormone effects
- Drug Solubulity and Delivery Systems
- Autophagy in Disease and Therapy
- Molecular Communication and Nanonetworks
- Hippo pathway signaling and YAP/TAZ
- Advanced Vision and Imaging
The University of Texas Health Science Center at San Antonio
2015-2025
The University of Texas Health Science Center at Houston
2021-2025
China Pharmaceutical University
2021-2025
Ministry of Education
2024
Jinan University
2024
The University of Texas at San Antonio
2024
National Institutes for Food and Drug Control
2023
Chongqing University of Science and Technology
2023
Guangxi University
2023
Hubei University
2023
Thymoquinone (TQ, 2-methyl-5-isopropyl-1,4-benzoquinone), a bioactive constituent extracted from the seeds of Nigella sativa, has been proved to exert anti-tumor efficiency in various cancers. Autophagy is self-digestion phenomenon, and its role tumor formation progression remains controversial. In present study, we investigated effects TQ on renal cell cancer (RCC) lines (786-O ACHN) using wound healing assay, transwell assay western blot analysis. We found that effectively inhibited...
Abstract The chemokine (C-C motif) ligand 2 (CCL2) with its cognate receptor (CCR2) plays important roles in tumor invasion and metastasis. However, the mechanisms mediators for autocrine CCL2 CCL2-CCR2 axis remain elusive breast cancer. Here we examined levels of 4 cancer cell lines along 57 human specimens found them significantly increased presence 17β-estradiol (E2) estrogen (ER)-positive cells, while anti-estrogen treatment weakened this enhancement. expression positively correlated...
Background and Purpose Deciphering chemical mechanism of action (MoA) enables the development novel therapeutics (e.g. drug repositioning) evaluation side effects. Development computational methods for MoA assessment under a systems pharmacology framework would accelerate discovery with greater efficiency low cost. Experimental Approach In this study, we proposed an improved network‐based inference method, balanced substructure‐drug‐target (bSDTNBI), to predict old drugs, clinically failed...
Programmed death-ligand 1 (PD-L1) expression on the surface of tumour cells can cause immune evasion. Benefits combining anti-PD-L1 therapy with nab-paclitaxel in patients advanced triple-negative breast cancer (TNBC) have been reported. However, some cannot tolerate immune-related adverse effects (irAEs) caused by antibody-based immunotherapy. BRD4 is a member bromodomain and extra-terminal domain (BET) family. inhibition has shown antitumour many tumours, but its role TNBC not definitively...
Ethnopharmacological relevance:The Wei Nai An capsule (WNAC); a complex made of 5 herbs, including Astragali Radix, Notoginseng Radix Et Rhizoma, Ginseng Rhizoma Rubra, Bovis Calculus, Pearl Powder. The WNAC has well documented therapeutic effect on stomach diseases chronic gastritis, epigastric pain, and peptic ulcer, while the herbs formula have been reported to treat diseases. However, mechanisms through which exerts its benefits not clearly defined.PurposeThe Cardiovascular (CVDs)...
Introduction: Thrombolytic and mechanical thrombectomy therapies are the current standard of care for large vessel occlusion (LVO) stroke. Multiple studies emphasized impact time metrics on patient outcomes, particularly door-to-needle door-to-puncture (DTP) times. Tenecteplase (TNK) offers potential advantages over alteplase (tPA), including a simplified one-time bolus administration, which may reduce DTP time. While suggested TNK is non-inferior to tPA in terms clinical few cohort have...
The endovascular treatment of complex middle cerebral artery (MCA) aneurysms, particularly dysplastic large MCA bifurcation can pose significant technical challenges. We aim to present three cases illustrating the nuances and challenges often encountered in Y-stent-assisted coiling (Y-SAC) for such aneurysms provide an update on nuances. consecutive each >10 mm with a wide neck. successfully performed Y-SAC all first attempt using "around world" technique used Neuroform Atlas Stent (Stryker...
The risk of diabetic cardiovascular complications is closely linked to the length hyperglycemia exposure. Mitophagy plays a significant role in vascular endothelial injury. However, specific mechanisms by which mitophagy contributes injury during sustained remain unclear. In ApoE-/- mice and human umbilical vein cell (HUVEC) models, enhanced following short-term long-term high-glucose Short-term exposure promotes Parkin-mediated upregulates mitochondrial fission protein 1 (Fis1) expression,...
The cell membrane is a major barrier for drug transport. Given that many cancer drugs must passively cross the membrane, understanding drug-membrane interactions crucial. We used fluorescence-activated sorting to investigate how cholesterol influences transport of ellipticine and pirarubicin across membranes. showed depletion helped membranes nonsmall lung carcinoma Chinese hamster ovary cells. In contrast, uptake was not strongly influenced by depletion. To study microscopic origins these...
Numerous studies have shown that the frequency of myeloid-derived suppressor cells (MDSCs) is associated with tumor progression, metastasis, and recurrence. Chemokine (C-C motif) ligand 3 (CCL3) may be secreted by attract MDSCs into microenvironment. In present study, we aimed to explore molecular mechanisms whereby CCL3 involved in interaction breast cancer MDSCs.The expression its receptors was investigated using real-time polymerase chain reaction, western blotting, enzyme-linked...
The pre-metastatic niche has been shown to play a critical role in tumor metastasis, and its formation is closely related the microenvironment. However, underlying molecular mechanisms remain unclear. In present study, we successfully established mouse model of lung metastasis using luciferase-expressing MDA-MB-435s cells. this model, recruitment vascular endothelial growth factor receptor-1 (VEGFR1)+CD133+ hematopoietic progenitor cells (HPCs) was gradually increased but decreased after...
We propose a new Eulerian-Lagrangian approach to simulate the various surface tension phenomena characterized by volume, thin sheets, filaments, and points using Moving-Least-Squares (MLS) particles. At center of our is meshless Lagrangian description different types codimensional geometries their transitions an MLS approximation. In particular, we differentiate codimension-1 codimension-2 on particles precisely describe evolution sheets discretize codimension-0 operators background...
The TMEM127 tumor suppressor gene encodes a transmembrane protein of unknown function mutated in pheochromocytomas and, rarely, renal cancers. Tumors with inactivating mutations have increased mTORC1 signaling by undefined mechanisms. Here we report that interacts the lysosome-anchored complex comprised Rag GTPases, LAMTOR pentamer (or 'ragulator') and vATPase, which controls amino acid-mediated activation. We found under nutrient-rich conditions expression reduces recruitment to Rags. In...
Emerging evidence shows that mitochondria fusion/fission imbalance is related to the occurrence of hyperglycemia-induced vascular injury. To study temporal dynamics mitochondrial fusion and fission, we observed alteration proteins in a set different high-glucose exposure durations, especially early stage hyperglycemia. The vitro results show persistent cellular apoptosis endothelial dysfunction can be induced rapidly within 12 hours' pre-incubation. Our maintain normal morphology function 4...
Abstract Understanding the molecular components of insulin signaling is relevant to effectively manage resistance. We investigated phenotype TMEM127 tumor suppressor gene deficiency in vivo. Whole-body Tmem127 knockout mice have decreased adiposity and maintain sensitivity, low hepatic fat deposition peripheral glucose clearance after a high-fat diet. Liver-specific adipose-specific deletion partially overlap global loss: liver promotes gluconeogenesis inhibits uptake, while adipose...
TIMP-2 gene plays an important role in the development of breast cancer. The present study was conducted to evaluate whether polymorphisms are associated with cancer risk a Han Chinese cohort.Six single nucleotide (SNPs) within 571 and 578 healthy control subjects were genotyped through Agena MassARRAY. Logistic regression analysis used assess influence on Functional annotation variants expression analyzed by bioinformatics.Bioinformatics found that rs4789936 likely affect transcription...
Interatomic potentials play a crucial role in the molecular dynamics (MD) simulation of silicon carbide (SiC). However, ability interatomic to accurately describe certain physical properties SiC has yet be confirmed, particularly for hexagonal SiC. In this study, mechanical, thermal, and defect four structures (3C-, 2H-, 4H-, 6H-SiC) have been calculated with multiple using MD method, then compared results obtained from density functional theory experiments assess descriptive capabilities...
Bone metastases (BMs) are common for breast cancer patients. However, triple-negative (TNBC) with BM is relatively rare and few data on it available. In this study, we aim to investigate the incidence clinicopathological features evaluate prognosis of TNBC patients BM.A total 616 (120 out them had BM) between 2007 2011 were involved in study. Clinicopathological characteristics statistically analyzed.A 120 (19.5%) developed a median age 53.1 years. The overall survival (OS) was 40 months,...
Distinguishing the surface markers of cancer stem cells ( CSC s) is a useful method for early diagnosis and treatment tumors, as s may participate in tumorigenesis metastasis by migrating into circulatory system. However, potential targets are expressed at low levels natural state always changing. Thus, dynamic screening has been reported to be an effective measure exploring markers. In recent years, diverse single‐chain variable fragments (scFvs) have widely used immunotherapy. this study,...
Cartoon-style pictures can be seen almost everywhere in our daily life. Numerous applications try to deal with cartoon pictures, a dataset of will valuable for these applications. In this paper, we first present ToonNet: cartoon-style image recognition dataset. We construct benchmark set by 4000 images 12 different classes collected from the Internet little manual filtration. extend basal 10000 adopting several methods, including snapshots rendered 3D models shader, 2D-3D-2D converting...