A5042931329- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- Metabolism, Diabetes, and Cancer
- melanin and skin pigmentation
- Colorectal and Anal Carcinomas
- Nutrition, Genetics, and Disease
- Histone Deacetylase Inhibitors Research
- Neurofibromatosis and Schwannoma Cases
- Cholinesterase and Neurodegenerative Diseases
- BRCA gene mutations in cancer
- Liver physiology and pathology
- Retinoids in leukemia and cellular processes
Shanxi Medical University
2016-2024
Shaanxi Provincial People's Hospital
2016-2024
Shaanxi Provincial People's Hospital
2013-2023
First Affiliated Hospital of Xi'an Jiaotong University
2009-2023
Weatherford College
2023
First Affiliated Hospital of Zhengzhou University
2021
Xi'an Jiaotong University
2009-2015
Air Force Medical University
2009
Hamamatsu University School of Medicine
2009
The recurrence and metastasis of breast cancer limit the effectiveness clinical treatments, making them important issues for clinicians to address. Tumor‑associated macrophages (TAMs) contribute regulating immune system. C‑C motif chemokine ligand 5 (CCL5) is an inflammatory that promotes chemotaxis on cells involved in immune/inflammatory response. Breast secrete CCL5 act THP‑1 cells, influencing invasion tumors. However, knowledge remains limited regarding mechanism underlying effects...
Abstract Background Rearranged during transfection ( RET ) has been proven to be a tumorigenic target in non-small cell lung cancers (NSCLCs). In -rearranged NSCLCs, molecular features and their impact on prognosis were not well illustrated, the activity of mainstay therapeutics currently compared. Methods Patients diagnosed with NSCLCs rearrangements analyzed for concomitant mutations, tumor mutation burden (TMB), PD-L1 expression, T receptor repertoire clinical outcomes chemotherapy,...
Previous studies have shown that histone deacetylase 6 (HDAC6) plays critical roles in many cellular processes related to cancer. However, its biological the development of melanoma remain unexplored. Our aim was investigate whether HDAC6 has a role human and understand underlying mechanism. In present study, expression up-regulated tissues cell lines. Knockdown significantly inhibited proliferation colony formation ability A375.S2 cells, promoted arrest at G0/G1 phase apoptosis....
The tumor microenvironment (TME) is a crucial factor in cancer progression. In breast cancer, cancer-associated fibroblasts (CAFs) and the derived stromal components have been recognized as comprising majority of pathological structure TME. this study, we show that metformin (Met), diabetes drug, transforms CAFs Met disrupts tumor-stromal cross talk by preventing cell transforming growth factor-β (TGF-β) signaling production stromal-derived factor-1 (SDF-1) interleukin-8 (IL-8) CAFs....
Malignant melanoma has the highest risk of mortality among all types skin cancer due to its highly metastatic potential. The ocular albinism type 1 (OA1) protein is a pigment cell‑specific glycoprotein, which shares significant structural and functional features with G protein‑coupled receptors. However, role OA1 in yet be elucidated. present study aimed investigate whether involved cell migration. was found stimulate migration dose‑dependent manner cultured human cells. Furthermore,...
AIM:To investigate the efficacy and side effects of combined therapy oxaliplatin capecitabine in patients with metastatic esophageal squamous cell cancer (ESCC) survival patients. METHODS:Sixty-four (median age 63 years) histological or cytological confirmation ESCC received 120 mg/m 2 intravenously on day 1 1000 orally twice daily days to 14 a 21-d treatment cycle as palliative chemotherapy.Each patient at least two cycles treatment.The efficacy, were evaluated. RESULTS:The partial response...
Human epidermal growth factor receptor (HER)‑2‑positive breast cancer accounts for ~25% of all cases, has a high propensity relapse, metastasis and drug resistance, is associated with poor prognosis. Therefore, it necessary to develop more effective therapeutic targets the treatment HER‑2‑positive cancer. CD44+/CD24‑/low currently most commonly used marker stem cells (CSCs), which are considered main cause relapse metastasis. In present study, ratio was almost zero in SK‑BR‑3 cells; however,...
We selected 13 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with breast cancer risk in the Chinese Han population. Upon statistical analyses of clinical data from 551 patients and 577 controls, we found that six SNPs cancer; namely, rs4973768(Odds ratio (OR) = 1.30, 95% confidence interval (CI) =1.01-1.67), rs981782(OR =1.30, CI=1.01-1.66), rs1432679(OR =0.84, CI=0.70-0.99), rs10759243(OR=1.30, 95%CI=1.09-1.55), rs10822013(OR =1.18, CI=1.00-1.39)...
Triple‑negative breast cancer (TNBC) is characterized by strong invasiveness, frequent local recurrence and distant metastasis, with poor prognosis. According to tumor angiogenesis theory, cells can obtain blood supply not only fusing host vessels, but also constructing a new vascular system through angiogenesis, so as continuously nutrients oxygen supply; this called vasculogenic mimicry (VM). In our previous study, differential expression profiles of miRNAs were examined gene chip in TNBC...
Gastric cancer (GC) is one of the most common malignancies globally, and its occurrence development are associated with genetic, dietary, biological, immune factors. Epstein-Barr virus-associated gastric (EBVaGC), as a special subtype GC, has become research hotspot in recent years. In patients advanced virus infection closely related to lymph node metastasis, depth tumor invasion, poor prognosis. There great clinical need for new treatment modality EBVaGC. Advances molecular biology...
Efforts to get a strong and sustained anti-tumour immune response induced by tumour specific antigen have failed, but sipuleucel-T has been approved the US Food Drug Administration (FDA). We noticed that exosomes secreted cells or may be crucially involved in response, whereas others had inconsistent findings on exosome involvement. Based network theory, we summarise research advances of speculate follow curve hypothesis. Exosomes activate simultabeously both activation tolerance, at...
An antibody-drug conjugate (ADC) of human epidermal growth factor receptor-2 (HER2) provides effective treatment for patients with HER2-positive non-small cell lung cancer (NSCLC). Exon 20 insertion mutations are the most common among HER2 mutations. This mutant subtype is highly drug-resistant, and receiving conventional often have a poor prognosis. Trastuzumab deruxtecan (T-DXd), novel anti-HER2 ADC, has emerged as option (mutated, expressed, amplified, alternated) NSCLC, based on several...
The survival of patients with advanced colorectal cancer (CRC) is variable. high rates recurrence, metastasis, and drug resistance make clinical treatment difficult, which needs to further develop therapeutic prognostic targets. Ribosomal RNA processing 12 homolog (RRP12), as a nucleolar protein involved in ribosome subunit maturation export, plays important roles cell cycle-related processes the response DNA damage, regulates occurrence development various cancers. primary aim this study...
Distinguishing the surface markers of cancer stem cells ( CSC s) is a useful method for early diagnosis and treatment tumors, as s may participate in tumorigenesis metastasis by migrating into circulatory system. However, potential targets are expressed at low levels natural state always changing. Thus, dynamic screening has been reported to be an effective measure exploring markers. In recent years, diverse single‐chain variable fragments (scFvs) have widely used immunotherapy. this study,...
Rationale: Gastric cancer is a common and lethal malignancy worldwide. It lacks specific clinical symptoms during the early stages, when detected, optimal surgical opportunity lost. Chemotherapy alone offers limited benefits in advanced inoperable disease or postoperative recurrence. heterogeneous tumor involving multiple gene regulations; thus, multi-target combination therapy trend research. The c-MET protein tyrosine kinase receptor belonging to MET family, encoded by proto-oncogene....
e23265 Background: BRAF mutations are frequently found in melanoma, non-small cell lung cancer (NSCLC), thyroid cancer, to a lesser degree other tumor types. These constantly activate the kinase domain and result MAPK pathway hyperactivation. Successful inhibition of this with BRAF/MEK inhibitors (BRAFi/MEKi) results clinically meaningful benefit for some patients. The RBAST study, assess efficacy survival outcomes inhibitor-based therapy were investigated patients solid tumors harboring...
BACKGROUND: The incidence of type 2 diabetes is rapidly increasing worldwide. Studies have shown that it also associated with cancer-related morbidities. Early detection cancer in patients crucial. OBJECTIVE: This study aimed to construct a model predict risk diabetes. METHODS: collected clinical data from total 5198 patients. A prediction was established by analyzing 261 items routine laboratory tests. We screened 107 factors tests based on the importance characteristic variables,...
e21001 Background: EGFR R776H is an uncommon exon 20 mutation in non-small cell lung cancer (NSCLC) patients. This was first reported samples after generation TKI treatment as acquired resistant to of EGFR-TKI. We further analyzed the molecular characteristics patients with and its correlation therapy. Methods: In this study, a total 16131 NSCLC from multiple centers NGS data were retrospectively study clinical outcomes mutation. Results: 44 (0.27%) had mutation, 28 them (63.6%)...
To investigate the effect of G4PAMAM/VEGFASODN compound on expression VEGF and mRNA in MDA-MB-231 breast cancer cells growth inhibition vascular endothelial cells.The diameter granule was measured by transmission electron microscopy, its stability under different pH also observed. The efficiency transfection vitro detected flow cytometer positively transfected were laser scanning confocal microscope. survival rate inhibitory determined MTT assay. protein immunohistochemical method RT-PCR.The...
44 Background: Immune checkpoint inhibitors (ICIs) have improved the therapeutic prospects in advanced gastrointestinal tumors. The PD-L1 expression has become one of predictive biomarkers for immunotherapy and used treatment, but there are still some drawbacks. aim this study was to investigate changes peripheral blood T-lymphocyte subsets, IL-6 levels before after treatment with ICIs clinical significance. Methods: 70 patients tumors who were hospitalized Shaanxi Provincial People's...