A5113110227- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Pregnancy and preeclampsia studies
- Health Systems, Economic Evaluations, Quality of Life
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Hereditary Neurological Disorders
- Protease and Inhibitor Mechanisms
- Lipoproteins and Cardiovascular Health
- EEG and Brain-Computer Interfaces
- Maternal and fetal healthcare
- Pharmacological Effects and Toxicity Studies
- interferon and immune responses
- Patient Satisfaction in Healthcare
- Hepatitis Viruses Studies and Epidemiology
- Neurology and Historical Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Hepatitis B Virus Studies
- Neurological Complications and Syndromes
- Neurological Disorders and Treatments
- Blood donation and transfusion practices
The University of Texas Southwestern Medical Center
2023-2025
Southwestern Medical Center
2025
Introduction: Thrombolytic and mechanical thrombectomy therapies are the current standard of care for large vessel occlusion (LVO) stroke. Multiple studies emphasized impact time metrics on patient outcomes, particularly door-to-needle door-to-puncture (DTP) times. Tenecteplase (TNK) offers potential advantages over alteplase (tPA), including a simplified one-time bolus administration, which may reduce DTP time. While suggested TNK is non-inferior to tPA in terms clinical few cohort have...
Importance Clinical practice guidelines recommend initiation of anticoagulation within 2 weeks after stroke with atrial fibrillation. It is unknown whether there an optimal starting day the 14-day period that balances risks recurrent embolic events against serious hemorrhagic events. Objective To determine if delay time to initiate treatment a direct oral anticoagulant fibrillation–related minimizes risk composite outcome ischemic or Design, Setting, and Participants This phase 2, pragmatic,...
Introduction: Clinical practice guidelines recommend initiation of anticoagulation within 2 weeks after stroke due to atrial fibrillation (AF). It is unknown whether there an optimal day that 14-day period balances the risks recurrent embolic vs serious hemorrhagic events. Methodology: The Lone Start Stroke START trial a pragmatic, prospective, multi-center, response-adaptive randomized Phase study 200 patients prescribed direct oral anticoagulant (DOAC) for secondary prevention AF. Patients...
Hypertensive disorders of pregnancy (HDP) pose significant risks to maternal and fetal health, with substantial mortality morbidity rates globally, particularly in developing countries. Pre-eclampsia (PE) accounts for a notable portion mortality, varied prevalence across regions within countries like India. Despite advancements, disparities healthcare access persist, influencing outcomes. PE not only affects health during but also predisposes women long-term cardiovascular complications,...
Preeclampsia and eclampsia are hypertensive disorders of pregnancy associated with significant maternal fetal morbidity mortality. Posterior reversible encephalopathy syndrome (PRES) is a neurological complication observed in these conditions, yet its impact on fetomaternal outcomes remains underexplored. The aim this study to investigate the association between PRES women preeclampsia eclampsia.
Introduction: Unlike state designation for trauma centers, there are no Texas State rules on certain infrastructure requirements stroke and independent center accreditation. To assess the current of program manager impact, a Stroke Program Survey was administered. Hypothesis: Lack results in overburdened programs, high turnover, poor mentorship, burnout. Methods: Electronic survey contained assessment with link to validated instrument (MBI-HSS), administered by Mind Garden Inc, burnout,...
Background: Screening is a valuable tool for triaging, protocol activation, and resource allocation in emergency medicine, yet no has been identified as superior the prehospital hospital setting. DESTINY was developed single to screen all stroke subtypes. Methods: This study Phase II prospective two part adaptive design validation of ED during early triage suspected patients from 05/01/2022 08/08/2022. CSTAT (questions: 2, 4, 5, 10) VAN 3, 6, 7, were embedded tool. incorporated into EHR...
Background: Screening is a valuable tool for triage, protocol activation, and resource allocation in emergency medicine, yet no identified as superior the prehospital or hospital setting. DESTINY screening developed single to screen all stroke subtypes. Methods: This study phase II prospective 2-part adaptive design validation of ED during early triage suspected patients from 05/01/2022 08/08/2022. CSTAT VAN were embedded tool. was incorporated into EHR standardized workflow nursing ED. The...
Introduction: Tenecteplase (TNK) has potential advantages over alteplase for treating acute ischemic stroke (AIS). Yet, TNK adoption is not universal. This mixed-methods study identifies common barriers and facilitators to implementation. Methods: We surveyed 40 Texas hospitals using qualitative interview a Likert questionnaire. Hospitals ranged from Acute Stroke Ready that had implemented Comprehensive Centers TNK. Qualitative themes were identified phenomenological approach with...
Introduction: Tenecteplase (TNK) presents potential advantages in the treatment of acute ischemic stroke (AIS) and is hypothesized to reduce door-to-needle times (DTN). Methods: The Lone Star Stroke (LSS) registry incorporates data from 9 (6 CSC, 3 PSC) Texas hospitals which have not switched TNK, mapping subject Get-With-the-Guidelines (GWTG) variables including patients who received alteplase (ALT) or TNK October 2019 March 2023. dataset stratified into ALT groups, generating a univariate...
Comparing Tenecteplase and Alteplase in Acute Ischemic Stroke Treatment throughout the state of Texas.
Introduction: Hepatitis B surface Antigen (HBsAGg) prevalence among pregnant women in India is between 0.9-3.1%. The most important factor determining the transmission from asymptomatic chronic Virus (HBV) mother to newborn. This study was done observe antiviral treatment and fetomaternal outcome HBV mothers. Aim: To outcomes hepatitis women. Materials Methods: prospective cohort enrolled 125 HBsAg seropositive singleton pregnancy over a period of 18 months October 2020 March 2022 at...