A5100438889- Cardiac electrophysiology and arrhythmias
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Neuroscience and Neural Engineering
- Cancer, Hypoxia, and Metabolism
- Quantum Computing Algorithms and Architecture
- Metabolism, Diabetes, and Cancer
- Advanced Chemical Sensor Technologies
- Drug Transport and Resistance Mechanisms
- Ion Channels and Receptors
- Lipid metabolism and disorders
- Ion channel regulation and function
- Microbial Metabolism and Applications
- Morinda citrifolia extract uses
- Cancer and Skin Lesions
- Medicinal Plants and Bioactive Compounds
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Peroxisome Proliferator-Activated Receptors
- ATP Synthase and ATPases Research
- Protein Structure and Dynamics
- Epigenetics and DNA Methylation
- ECG Monitoring and Analysis
- Pelvic floor disorders treatments
- Computational Physics and Python Applications
Institute of Hematology & Blood Diseases Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
University of Aizu
2019-2024
Tea Research Institute
2023-2024
Guizhou Academy of Agricultural Sciences
2023-2024
National Clinical Research
2024
Xiangya Hospital Central South University
2024
Central South University
2024
PharmacoGenetics (China)
2024
Affiliated Hospital of Guizhou Medical University
2024
Umami amino acids inhibit the bitter and astringent taste presentation of catechins, which is essential for regulation green tea. In this study, concentration-intensity trends threshold properties major catechin monomers were investigated using an electronic tongue. The chemical structure interactions between ester-type catechins theanine, glutamic acid (Glu), aspartic (Asp) further analyzed by in vitro simulation analysis their reciprocal structures. results showed that bitterness...
Lactate dehydrogenase A (LDHA) is upregulated in multiple cancer types and contributes to the Warburg effect. Several studies have found that many tumor‐related genes subtypes play important roles promoting development. Here, we identified a novel LDHA transcript, which produced new protein 3 kDa larger than LDHA, named LDHAα. We cell lines express LDHAα, ectopic expression of LDHAα led higher proliferation migration rate vitro . Ectopic could also promote tumor growth vivo Conversely,...
Background and Study Aims Small polyps are occasionally missed during colonoscopy. This study was conducted to validate the diagnostic performance of a polyp‐detection algorithm alert endoscopists unrecognized lesions. Methods A computer‐aided detection (CADe) developed based on convolutional neural networks using training data from 1991 still colonoscopy images 283 subjects with adenomatous polyps. The CADe evaluated validation dataset including 50 short videos 1–2 (3.5 ± 1.5 mm, range 2–8...
Automatic polyp detection is reported to have a high false-positive rate (FPR) because of various polyp-like structures and artifacts in complex colon environment. An efficient polyp's computer-aided (CADe) system should sensitivity low FPR (high specificity). Convolutional neural networks been implemented colonoscopy-based automatic achieved performance improving rate. However, environments caused excessive false positives are going prevent the clinical implementation CADe systems. To...
Background and study aims Colorectal cancers (CRC) with deep submucosal invasion (T1b) could be metastatic lesions. However, endoscopic images of T1b CRC resemble those mucosal CRCs (Tis) or superficial (T1a). The aim this was to develop an automatic computer-aided diagnosis (CAD) system identify based on plain images. Patients methods In two hospitals, 1839 non-magnified from 313 (Tis 134, T1a 46, 56, beyond 37) sessile morphology were extracted for training. A CAD trained the data...
The assessment of catechin content stands as a pivotal determinant tea quality. In production and quality grading, the development accurate non-destructive techniques for prediction various is paramount. Near-infrared spectroscopy (NIRS) has emerged widely employed tool analyzing chemical composition tea. Nevertheless, spectral information obtained from NIRS faces challenges when discerning different types catechins in black tea, owing to their similar physical properties. Moreover, vast...
A Ca2+-activated monovalent cation-selective TRPM4 channel is abundantly expressed in the heart. Recently, a single gain-of-function mutation identified distal N-terminus of human (Glu5 to Lys5; E7K) was found be arrhythmogenic because enhanced cell membrane expression. In this study, we conducted detailed analyses mutant from more functional aspects, comparison with its wild type (WT). an expression system, intracellular application short soluble PIP2 (diC8PIP2) restored single-channel...
An acute psychological stress can precipitate ventricular arrhythmias and sudden cardiac death in patients with coronary artery disease (CAD). However, the physiologic mechanisms by which these effects occur are not entirely clear. Mental stress-induced myocardial ischemia occurs a significant percentage of CAD population. It is unknown if proarrhythmic mediated through development ischemia.To examine on QT dispersion (QTd) among whether via ischemia.Psychological was induced using public...
In the heart, TRPM4 is most abundantly distributed in conduction system. Previously, a single mutation, ‘E7K’, was identified its distal N-terminus to cause disorder because of enhanced cell-surface expression. It remains, however, unclear how this expression increase leads failure rather than abnormally cardiac excitability. To address issue theoretically, we mathematically formulated gating kinetics E7K-mutant channel by combined use voltage jump analysis and ionomycin-perforated...
The simulation of electrophysiological cardiac models plays an important role in facilitating the investigation behavior under various conditions. However, these simulations often require a lot computational resources.
Variational quantum algorithms (VQAs) have shown potential for advantage with noisy intermediate-scale (NISQ) devices machine learning (QML). However, given the high cost and limited availability of resources, delegating VQAs via cloud networks is a more practical solution clients capabilities. Recently, Shingu et al.[Physical Review A, 105, 022603 (2022)] proposed variational secure computing protocol, utilizing ancilla-driven computation (ADQC) cloud-based minimal resource consumption....
The objective of this study is to explore whether sodium valproate (VPA) alleviates epileptic seizures via suppressing lysyl oxidase (Lox)-mediated ferroptosis. Epileptic seizure mouse model was prepared intrahippocampal injection kainic acid (250 ng/μl). After treatment with acid, VPA injected intraperitoneally by the dose 250 mg/kg twice daily for 4 days. Ferroptosis-associated indices including lipid peroxides (LPO) level and Ptgs2 mRNA in hippocampal tissue samples were detected....
Abstract Purpose This study aimed to investigate anterior segment parameters in patients with exfoliation syndrome (XFS) and glaucoma (XFG). Methods The adopted a retrospective case series design, involving total of 56 (112 eyes) unrelated XFS/XFG (XFS: 26 patients/60 eyes; XFG: 30 patients/44 100 age-related cataract cases as the control group (200 eyes). participants were evaluated at ophthalmology department First Affiliated Hospital Xinjiang Medical University. Clinical data, including...
Chemical composition of the essential oil from Qiancao roots was analyzed by gas chromatography-mass spectrometry (GC-MS), and 43 components were identified in paper. Mollugin (30.58%) found to be major component, followed 3-methyl-2-cyclopenten-1-one (10.55%), 4-tert-butyl-2-phenyl-phenol (8.64%) eugenol (6.30%). The antibacterial activity against selected food-borne pathogens evaluated. results showed that sensitivity different for tested bacteria had a strong B. cereus with lowest minimum...
Objective To provide an effective imaging technique for the morphological observation of urogenital hiatus in pelvic organ prolapse women using three-dimensional ultrasound. Methods In a prospective observational study, forty patients with and thirty nulliparous underwent transperineal ultrasound, supine after bladder emptying. The ultrasound volume was acquired form, structure, composition size urogeital were observed axial plane set by interior-inferior edge symphsis pubis analrectum...
The design of novel peptide sequence and investigations the mechanisms underlying cell adhesion are critical for culture human induced pluripotent stem cells (hiPSCs) on displaying surfaces. Recently, we reported that near-D amino acid sequences play an important role in function whole RGD-containing peptides. In this study, two peptides with Ac-KGGTYRAYRGDVFTMP Ac-KGGVFTMPRGDTYRAY were designed from Fortunately, exhibited excellent ability sustaining cultures hiPSCs. Moreover, predicted...
Abstract Background Corrected QT (QTc) interval has been reported to be associated with type 2 diabetes. This study aimed explore the relationship between different glucose tolerance and QTc among middle-aged older Chinese individuals. Methods We conducted a cross-sectional analysis that included 9898 subjects (3194 men 6704 women) in population. Glucose was studied during OGTT. Insulin, blood pressure, HbA1c, serum lipids, hepatic transaminases waist-to-hip ratio were assessed.The derived...