A5087427573- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intensive Care Unit Cognitive Disorders
- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Long-Term Effects of COVID-19
- Blood Coagulation and Thrombosis Mechanisms
- Vitamin C and Antioxidants Research
- SARS-CoV-2 and COVID-19 Research
- Vitamin D Research Studies
- Regulation of Appetite and Obesity
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Inflammation biomarkers and pathways
- S100 Proteins and Annexins
- Cancer, Hypoxia, and Metabolism
- Acute Kidney Injury Research
- Coenzyme Q10 studies and effects
- Exercise and Physiological Responses
- Thermal Regulation in Medicine
- Sphingolipid Metabolism and Signaling
- Abdominal Trauma and Injuries
National and Kapodistrian University of Athens
2012-2023
Evangelismos Hospital
2013-2023
Thorax Foundation
2018
Importance Although vaccination substantially reduces the risk of severe COVID-19, it is yet unknown whether vaccinated patients who develop COVID-19 and require invasive mechanical ventilation have lower mortality than controls. Objective To examine association between status among critically ill owing to acute respiratory distress syndrome (ARDS) related COVID-19. Design, Setting, Participants This multicenter cohort study was performed June 7, 2021, February 1, 2022, 265 consecutive adult...
Abstract Introduction Gene expression profiling was performed via DNA microarrays in leukocytes from critically ill trauma patients nonseptic upon admission to the ICU, who subsequently developed either sepsis ( n = 2) or severe and acute respiratory distress syndrome 3). By comparing our results with published studies animal models of lung injury, we found aquaporin-1 be differentially expressed across all studies. Our aim determine how water channel is involved regulating immune response...
Coronavirus disease-19 (COVID-19) continues to be a health threat worldwide. Increased blood lactate is common in intensive care unit (ICU) patients; however, its association with outcomes ICU COVID-19 patients remains currently unexplored. In this retrospective, observational study we assessed whether associated patients. Blood was measured on admission and thereafter daily up day 14 45 confirmed pneumonia. Acute physiology chronic evaluation (APACHE II) calculated admission, sequential...
Congenital central hypoventilation syndrome (CCHS) is an uncommon disorder characterized by the absence of adequate autonomic control respiration, which results in alveolar and decreased sensitivity to hypercarbia hypoxemia, especially during sleep. Patients with CCHS need lifelong ventilatory support. The treatment options for include intermittent positive pressure ventilation administered via tracheostomy, noninvasive ventilation, negative-pressure body chamber or cuirass, phrenic nerve...
Abstract Background Before the pandemic of coronavirus disease (COVID-19), rapidly improving acute respiratory distress syndrome (ARDS), mostly defined by early extubation, had been recognized as an increasingly prevalent subphenotype (making up 15–24% all ARDS cases), associated with good prognosis (10% mortality in ARDSNet trials). We attempted to determine prevalence and persistent severe related COVID-19. Methods included consecutive patients COVID-19 receiving invasive mechanical...
Acute kidney injury (AKI) is one of the most common complications in critically ill patients. In recent years, studies have focused on exploring new biomarkers for early diagnosis and prognosis AKI. The aim this study was to investigate serum prognostic (neutrophil gelatinase-associated lipocalin, NGAL, creatinine) AKI included 266 ill, initially nonseptic, patients admitted a multidisciplinary ICU. Serum levels NGAL creatinine were measured at ICU admission. ROC curves generated estimate...
Background/hypothesis: Whole body exercise (WBE) changes lymphocyte subset percentages in peripheral blood. Resistive breathing, a hallmark of diseases airway obstruction, is form for the inspiratory muscles. Strenuous muscle contractions induce oxidative stress that may mediate immune alterations following exercise. We hypothesized resistive breathing (IRB) alters blood subsets and mediates subpopulation both WBE IRB. Patients methods: Six healthy nonathletes performed two IRB sessions 45...
Hypoxia is characterized as one of the main consequences sepsis, which recognized leading cause death in intensive care unit (ICU) patients. In this study, we aimed to examine whether expression levels genes regulated under hypoxia could be utilized novel biomarkers for sepsis prognosis ICU Whole blood hypoxia-inducible factor-1α (HIF1A), interferon-stimulated gene 15 (ISG15), hexokinase 2 (HK2), lactate dehydrogenase (LDHA), heme oxygenase-1 (HMOX1), erythropoietin (EPO), and vascular...
In the last years, biomarkers of infection, such as soluble urokinase plasminogen activator receptor (suPAR), have been extensively studied potential diagnostic and prognostic in intensive care unit (ICU). this study, we investigated whether biomarker can be used COVID-19 non-COVID-19 septic patients for mortality prediction. Serum suPAR levels were measured 79 critically ill upon sepsis (within 6 h), on admission 95 (66 critical 29 moderate/severe). The matched age, sex, disease severity,...
The pathogenesis of sepsis involves complex interactions and a systemic inflammatory response leading eventually to multiorgan failure. Autotaxin (ATX, ENPP2) is secreted glycoprotein largely responsible for the extracellular production lysophosphatidic acid (LPA), which exerts multiple effects in almost all cell types through its at least six G-protein-coupled LPA receptors (LPARs). Here, we investigated possible role ATX/LPA axis an animal model endotoxemia as well septic patients. Mice...
Mucormycosis has emerged as a group of severe infections mainly in immunocompromised patients. We analysed the epidemiology mucormycosis Greece multicentre, nationwide prospective survey patients all ages, during 2005-2022. A total 108 cases were recorded. The annual incidence declined after 2009 and appeared stable thereafter, at 0.54 cases/million population. most common forms rhinocerebral (51.8%), cutaneous (32.4%), pulmonary (11.1%). Main underlying conditions haematologic...
Aging negatively affects the endothelium. Endocan (ESM-1), an endothelium-derived soluble proteoglycan, participates in fundamental biological processes of endothelial cells. We aimed to examine role dysfunction and age poor outcomes critical illness. ESM-1 levels were measured sera mechanically ventilated critically ill patients, including COVID-19, non-septic, septic patients. The 3 patient cohorts divided based on (≥65 <65). Critically COVID-19 patients had statistically higher...
The endothelial protein C receptor (EPCR) is a that regulates the anticoagulant and anti-inflammatory pathways. A soluble form of EPCR (sEPCR) circulates in plasma inhibits activated (APC) activities. clinical impact sEPCR its involvement COVID-19 has not been explored. In this study, we investigated whether levels were related to patients' requirement for hospitalization.Plasma measured on hospital admission 84 patients, 11 non-hospitalized SARS-CoV2-positive patients approximately 6 days...
ABSTRACT Introduction: To examine whether very low levels of 25-hydroxyvitamin D {25(OH)D} upon admission to the intensive care unit (ICU) are associated with worse outcomes. Methods: Retrospective observational cohort study critically ill patients treated in a multidisciplinary ICU. Two hundred twenty seven initially non-septic, patients, whom was measured at ICU admission. An additional group 192 healthy subjects also used. Patients were categorized according their vitamin admission; two...
The outbreak of the new coronavirus strain SARS-CoV-2 (COVID-19) highlighted need for appropriate feeding practices among critically ill patients admitted to intensive care unit (ICU). This study aimed describe intubated COVID-19 during their second week hospitalization in First Department Critical Care Medicine, Evaggelismos General Hospital, and evaluate potential associations with all cause 30-day mortality, length hospital stay, duration mechanical ventilation. We enrolled adult ICU...
Background: The increased oxidative stress resulting from the inflammatory responses in sepsis initiates changes mitochondrial function which may result organ damage, most common cause of death intensive care unit (ICU). Deficiency coenzyme Q10 (CoQ10), a key cofactor respiratory chain, could potentially disturb bioenergetics and stress, serve as biomarker dysfunction. Hence, we aimed to investigate initially non-septic patients whether CoQ10 levels are decreased septic shock compared ICU...
Studies have hypothesized a potential role of the interleukin (IL)-23/17 axis in coronavirus disease 2019 (COVID-19). However, to date, levels IL-23 and 17 not been compared between critically ill COVID-19 patients non-COVID-19 patients. were measured on admission intensive care unit (ICU) (N = 38) 34) with an equal critical illness severity. Critically did sepsis or septic shock ICU admission. None enrolled had previously received corticosteroids. In our study, circulating IL-17 higher More...
Lately, studies have reported contradicting results on the cytokine storm seen in critically-ill COVID-19 patients. Depending control group used, cytokines been found to be higher, similar or even lower compared critical illnesses associated with elevated concentrations. However, most of these do not take into account illness severity. Hence, we decided compare levels patients and a general intensive care unit (ICU), who did sepsis septic shock, but had an equal disease severity.Interleukin...
A soluble (s) form of the endothelial protein C receptor (EPCR) circulates in plasma and inhibits activated (APC) activities. The clinical impact sEPCR its involvement septic process is under investigation. This study determined frequencies EPCR haplotypes H1 H3 to investigate possible associations with admission levels an intensive care unit (ICU) cohort patients. Three polymorphisms gene were genotyped 239 Caucasian critically ill patients, their also measured at time ICU. Multivariate...