A5003968984- PARP inhibition in cancer therapy
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- DNA Repair Mechanisms
- Cell death mechanisms and regulation
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Antifungal resistance and susceptibility
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Screening and Detection
- Thyroid Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
National and Kapodistrian University of Athens
2015-2025
University General Hospital Attikon
2011-2025
St Savas Hospital
2023
Sotiria General Hospital
2023
University of Crete
1998-2003
Evangelismos Hospital
1996
The General Hospital of Heraklion "Venizeleio-Pananio"
1996
University Hospital of Heraklion
1995-1996
BackgroundProgrammed cell death protein 1(PD-1) axis blockade has become the mainstay in treatment of recurrent and/or metastatic (R/M) head and neck squamous cancer (HNSCC). PD-L1 is only approved biomarker for patient selection; however, response rate limited even among high expressors. Our primary objective was to investigate association immune-cell-related biomarkers tumor microenvironment with PD-1 checkpoint inhibitors' outcomes patients R/M HNSCC.Patients methodsNCT03652142 a...
The tumour-host interaction at the invasive front of colorectal cancer, including epithelial–mesenchymal transition and its hallmark ‘tumour budding’, is an important area investigation in terms prognosis. aim this study was to determine prognostic impact a ‘pro-/anti-tumour’ approach defined by established ‘pro-tumour’ (tumour budding) host-related ‘anti-tumour’ factor adaptive immunological microenvironment (CD8+ lymphocytes). Double immunostaining for CK22/CD8 on whole tissue sections...
DICER1 syndrome (DICERs) represents a tumor predisposition genetic syndrome, inherited in an autosomal dominant manner. Germline loss-of-function variants of the gene lead to impaired processing microRNA, expression, and increased risk tumorigenesis. Although pleuropulmonary blastoma (PPB) is hallmark multiple extrapulmonary malignant non-malignant conditions have also been described, including multinodular goiter (MNG) sex-cord stromal tumors. MNG one most common components associated with...
Background/Objectives: There are limited data regarding immunohistochemical profiling of immune cells in bone marrow trephine biopsies patients with high-risk myelodysplastic syndromes (HR-MDS). Methods: We sought to objectively quantify, the use digital pathology, density (cells/mm2) prominent adaptive immunity cell populations sixty-four (64) HR-MDS receiving 5-Azacytidine. focused on CD3(+) T cells, CD8(+) cytotoxic (Tc), helper (Th), Foxp3(+) regulatory (Tregs), CD20(+) B-cells and...
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial, wide-spectrum disorder. Small intestinal bacterial overgrowth (SIBO) characterized by an increase in the number and/or type of colonic bacteria upper gastrointestinal tract. SIBO, through energy salvage and induction inflammation, may be pathophysiological factor for NAFLD development progression.Consecutive patients with histological, biochemical, or radiological diagnosis any stage (non-alcoholic [NAFL], non-alcoholic...
<b>Background and study aims</b> Full-spectrum colonoscopy (FSC) promises to increase adenoma detection by providing a wider field of view. The aim this was compare miss rates FSC with those conventional complemented right-colon re-examination using scope retroflexion (CC/R). <b>Patients methods</b> At two tertiary endoscopy facilities, patients who were scheduled for the assessment symptoms or colorectal cancer screening/surveillance randomized (1:1) undergo same-day, back-to-back...
Background. Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought play a key role. Objectives. To investigate the expression of vascular endothelial growth factor (VEGF) CD31 as angiogenetic markers in postradiation rectal tissue. Methods. Rectal mucosa biopsies from 11 patients who underwent irradiation for prostate cancer were examined immunohistochemically VEGF at three time settings-before, completion of, 6 months after...
Simultaneous development of adenocarcinoma and primary B cell lymphoma mucosa-associated lymphoid tissue (MALT) the colon is rare; only one case has so far been reported out 13 cases with coexistence colonic involvement by lymphoma. We hereby present three more cases, two females (aged 75 71 years) a male 72 years). All underwent colectomy based on preoperative biopsy revealing carcinoma. Histological examination resection specimens disclosed in whereas tubulovillous adenoma superficial foci...
Lymphoepithelial or lymphoepithelioma-like carcinoma is a poorly differentiated located outside the nasopharynx with similar morphologic characteristics to its nasopharyngeal counterpart. of lung rare subtype squamous cell frequently associated Epstein-Barr virus (EBV) infection, accounting for approximately 1% non-small carcinomas (NSCLC). We herewith present case 78-year-old female patient who was diagnosed lymphoepithelial lung, emphasizing distinct epidemiological features, clinical...
Background: The aim of the study was to determine whether expression baseline phosphorus (P) and magnesium (Mg) levels were prognostic in terms stage overall survival (OS) newly diagnosed non-small cell lung cancer (NSCLC) small (SCLC) patients. Materials Methods: Retrospectively, 130 patients selected at time diagnosis oflung (100 with NSCLC 30 SCLC), before initialization any chemo-radiotherapy. median age 67 (range 29-92). IA, IB, IIA, IIB, IIIA, IIIB IV stages present 3, 4, 19, 6, 25, 8,...
Purpose: We conducted a phase II randomized noncomparative window of opportunity (WOO) trial to evaluate the inhibition cellular proliferation and modulation immune microenvironment after treatment with olaparib alone or in combination cisplatin durvalumab patients operable head neck squamous cell carcinoma (HNSCC). Experimental Design: Forty-one HNSCC were plus (arm A), B), no C) D). The primary endpoint was percentage each arm that achieved reduction at least 25% Ki67. Secondary endpoints...