A5032255984- Cholinesterase and Neurodegenerative Diseases
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- Folate and B Vitamins Research
- Muscle metabolism and nutrition
- Heavy Metal Exposure and Toxicity
- Mitochondrial Function and Pathology
- Biochemical Analysis and Sensing Techniques
- Neonatal Health and Biochemistry
- Pesticide Exposure and Toxicity
- Ion Transport and Channel Regulation
- Pharmacological Effects and Toxicity Studies
- Biochemical effects in animals
- Ion channel regulation and function
- Exercise and Physiological Responses
- Coenzyme Q10 studies and effects
- Thyroid Disorders and Treatments
- Trace Elements in Health
- Biomedical Research and Pathophysiology
- Alzheimer's disease research and treatments
- Chemical Reaction Mechanisms
- Liver Disease and Transplantation
- Sulfur Compounds in Biology
- Adipose Tissue and Metabolism
National and Kapodistrian University of Athens
2007-2019
Evangelismos Hospital
2019
Athens State University
2006-2010
University of Tsukuba
2008
Czech Academy of Sciences, Institute of Physiology
2008
Children's Hospital Agia Sophia
2005
Institute of Child Health
2005
Boston Children's Hospital
2001
Boston Children's Museum
2001
National Centre of Scientific Research "Demokritos"
1984
Phosphatidylserine (PtdSer) incubated with synaptosomal plasma membranes (SPM) of dog brain is incorporated into SPM in proportion to its concentration the incubation medium. Low PtdSer concentrations progressively activated SPM-associated (Na+ + K+)-stimulated ATPase and acetylcholinesterase. Increasing above that which maximally stimulated enzyme activities effected a progressive inhibition respect maximal stimulation. Arrhenius plots K+ Mg2+)-dependent 5′-nucleotidase revealed clear break...
Abstract: This study was undertaken in order to investigate: a) the short‐ and long‐term vivo effects of cadmium (Cd) on brain acetylcholinesterase (AChE), (Na + ,K )‐ATPase Mg 2+ ‐ATPase activities adult rats, b) concentration‐dependent vitro (acute experiment) Cd activity those enzymes, c) antioxidant L‐cysteine (Cys) above enzyme activities, d) evaluation total status after Cd, L‐cysteine, or L‐cysteine+Cd administration rats. In vitro, CdSO 4 inhibited pure AChE concentrations higher...
Summary: Purpose: Valproic acid (VPA) is an effective antiepileptic drug (AED), which associated with dose‐related adverse reactions such as skin rash, hair loss (alopecia), etc. Profound well partial biotinidase deficiency causes dermatologic manifestations similar these. Therefore, it was of interest to evaluate serum activity in patients receiving VPA monotherapy. Methods: Seventy‐five seizures, mean age, 8.6 years (±1.9 years) were divided into three groups. Group A (n = 25) treated 28.7...
Abstract The aim of this study was to investigate whether the preincubation brain homogenates with L-phenylalanine (Phe), L-cysteine (Cys) or reduced glutathione (G SH) could reverse free radical effects on Na + ,K -ATPase activity. Two well established systems were used for production radicals: 1) FeSO 4 (84 μᴍ ) plus ascorbic acid (400 and 2) , H 2 O (1 mᴍ) 10 min at 37 °C in adult rat whole brain. Changes activity total antioxidant status (TAS) studied presence each system separately,...
Abstract: We have previously reported that cadmium (Cd) as 3CdSO 4 · 8H 2 O decreases rat brain total antioxidant status and L‐cysteine (Cys) has a protective effect against it. The aim of the present study was to investigate effects subacute Cd administration, either alone or (almost simultaneously) with zinc (Zn), calcium (Ca) Cys, on acetylcholinesterase (AChE) activity in male adult rats. All substances were administered intraperitoneally. Cadmium (1 mg/kg/day for 14 days) increased AChE...
The mean miniature end-plate potential (m.e.p.p.) frequency and the acetylcholinesterase (AChE) activity have been examined in rat diaphragm, relation to time of Li+ action. Substitution LiCl for NaCl caused increase m.e.p.p. frequency, final level which depended on concentration bath solution. Incubation diaphragm homogenate with initially a slight AChE activity, reaching plateau after 20 min. produced an maximum, followed by decrease minimum. consequently returned steady level. During...
Abstract: Manganese (Mn) is an essential metalloenzyme component that in high doses can exert serious oxidative and neurotoxic effects. The aim of this study was to investigate the potential effect antioxidant l ‐cysteine (Cys, 7 mg/kg) on adult rat brain total status (TAS) activities acetylcholinesterase (AChE), Na + ,K ‐ATPase Mg 2+ induced by short‐term Mn administration (as chloride, 50 mg/kg). Twenty‐eight male Wistar rats were divided into four groups: A (saline‐treated control), B...