A5100372795- RNA modifications and cancer
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Axon Guidance and Neuronal Signaling
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Kruppel-like factors research
- Wnt/β-catenin signaling in development and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Liver Disease and Transplantation
- Nuclear Receptors and Signaling
- Chromatography in Natural Products
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hippo pathway signaling and YAP/TAZ
- Liver Disease Diagnosis and Treatment
- Connective Tissue Growth Factor Research
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Parasitic Diseases Research and Treatment
Chengdu Third People's Hospital
2024
Southwest Jiaotong University
2024
Central South University
2013-2023
Xiangya Hospital Central South University
2013-2023
Weatherford College
2020
Creative Commons
2019
Fudan University
2017
Zhongshan Hospital
2017
Southern Medical University
2015
Institute of Microbiology
2012
Papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) is a newly identified non-coding RNA, which highly thyroid-specific. Dramatic downregulation in cancers suggests its potential roles the occurrence and development of tumors. The present study aimed to investigate effects PTCSC3 on biological features cancer cells explore possible function as competing endogenous RNA bind with miRNAs. Constructs containing long PTCSC3, were transfected into various cell lines (BCPAP, FTC133...
Many recent studies have demonstrated the predominant role chronic inflammation plays in cancer cell propagation, angiogenesis and immunosuppression. Cancer-related (CRI) has been shown to correlate with poor prognosis. Our study aimed evaluate prognostic value of neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) patients hepatocellular carcinoma (HCC) who undergone liver resection.Between 2012 2015, 239 HCC had resection at XiangYa Hospital Central South University were...
Abstract Hepatocellular carcinoma (HCC) remains the primary cause of cancer-related death. Metabolic change is major characteristic cancer. The present study attempted to investigate regulatory mechanisms HCC energy metabolism from perspective noncoding RNA regulation HIF1A and LDHA. expression miR-100-5p was significantly suppressed in tissue samples cell lines under 1% O 2 -induced hypoxia. overexpression hypoxia-induced increases lactate concentration glucose uptake. Exposure induced...
Abstract Epithelial-mesenchymal transition (EMT) is a critical step in the metastasis of hepatocellular carcinoma (HCC). BTB/POZ domain-containing protein 7 (BTBD7) regulates EMT-associated proteins implicated HCC progression. However, role(s) BTBD7 have not been identified. Using highly metastatic HCCLM3 cells, immortalized L02 hepatocytes, animal models, and three independent cohorts patient specimens, we aimed to determine involvement metastasis. We show that messenger RNA was expressed...
Abstract RNF2 is a RING domain-containing E3 ubiquitin ligase that mediate histone H2A mono-ubiquitination to repress gene transcription, but its expression patterns and molecular function in hepatocellular carcinoma (HCC) remain unclear. Herein, we extracted data from TGCA database validated our own cohort, which revealed was highly expressed HCC associated with malignant characteristics poor prognosis of HCC. Moreover, demonstrated promote metastasis via enhancing epithelial-mesenchymal...
Anaplastic thyroid carcinoma (ATC) is an aggressive malignant disease in older adults with a high mortality rate. The present study aimed to examine several key genes and pathways, which are associated ATC. GSE33630 gene expression profile was downloaded from the Gene Expression Omnibus database, included 11 ATC 45 normal samples. differentially expressed (DEGs) were identified using Limma package R. Ontology functions Kyoto Encyclopedia of Genes Genomes pathways selected DEGs enriched...
Objective: MAGI1 (membrane-associated guanylate kinase, WW and PDZ domain containing 1) plays an important role in stabilization of adherens junctions suppression invasiveness metastasis. However, its expression clinical revelance hepatocellular carcinoma (HCC) are still unknown. So, this study was performed to detect the significance human HCC. Methods: The mRNA protein levels were examined by using reverse transcription-PCR (RT-PCR) Western blotting 31 paired HCC paracarcinomatous liver...
// Yiming Tao 1 , Kuan Hu Fengbo Tan Sai Zhang 2 Ming Zhou 3 Jia Luo 4 and Zhiming Wang Department of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China Institute Medical Sciences, Cancer Research, Hunan Provincial Tumor Correspondence to: Wang, email: Keywords : hepatocellular carcinoma, SH3-domain binding protein 1, Wiskott-Aldrich syndrome family verproline-homologous 2, metastasis, prognosis Received July 11, 2015 Accepted February 2016 Published...
Abstract Introduction: Choice of treatment in patients with symptomatic polycystic liver diseases (PLD) remains controversial. Various surgical procedures aiming at eliminating cysts are widely used mild and advanced PLD patients, but transplantation is currently recommended as the only curative especially severe cases. Patient concerns: Case 1: A 51-year-old male was admitted for eating disorder dyspnea 2 months. He had been diagnosed PLD, PKD, hypertension 9 years, antihypertensive drug...
Previous studies have shown that semaphorin-3F (SEMA3F) functions as a tumor suppressor in several types. However, the role of SEMA3F metastasis and prognosis liver hepatocellular carcinoma (LIHC) remains unknown. In this study, by performing bioinformatics analysis on transcriptome profiles from The Cancer Genome Atlas (TCGA), we demonstrated was significantly upregulated LIHC tissues, compared with normal controls. Moreover, expression value positively correlated patients' pathological...
The overall response rate of hepatocellular carcinoma (HCC) to chemotherapy is poor. In our previous study, oxaliplatin-resistant HCC found exhibit an enhanced stemness, and increased levels CCN2 LRP6, while the role LRP6 in prognosis patients, interaction regulation mechanism between are still unclear. expression were detected large cohorts HCCs, functional analyses performed both vitro vivo. roles cell surface heparin sulfate proteoglycans (HSPGs) mutual regulatory verified HCC,...
Objective: BolA family member 2 (BOLA2) is a novel gene highly associated with human hepatocellular carcinoma (HCC) progression.Tumor hemorrhage (TH) acts as poor marker for HCC patients and community affair in the tumor microenvironment.In present study, we examined possible association between BOLA2 levels TH.Methods: The mRNA protein of were determined two independent cohorts specimens by quantitative real-time polymerase chain reaction (qRT-PCR) immunohistochemistry (IHC) analysis,...
Microvascular invasion (MVI) is a critical prognostic factor for operable hepatocellular carcinoma (HCC). This study aimed to explore the performance of circulating tumour DNA (ctDNA) in evaluating MVI status preoperatively.Seventy-three HCC patients were enrolled and randomly divided into training cohort validation 2:1 ratio, preoperative blood surgical tissue samples obtained. Genomic alterations analysed using targeted deep sequencing with 1021-gene panel.In cohort, 260 somatic mutations...
Cholangiocarcinoma (CCA) is the second most common hepatic malignancy. Progress and developments have also been made in field of CCA management along with increasing scientific publications during past decades, which reflect topics general interest suggest future direction studies. The purpose this bibliometric study to summarize 25 years using a machine learning method.Scientific focusing on from 1995 2019 were searched PubMed MeSH term "cholangiocarcinoma." Full associated data downloaded...
Assessment of hepatic functional reserve is important to enable the selection appropriate treatment methods and safe resection in hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC). In present study, an evaluation was made clinical value combining Child‑Pugh score (CPS) with standardized future liver remnant (sFLR) measurement predict postoperative dysfunction (PLD). A total 61 HBV‑related HCC patients undergoing volumetry prior hepatectomy were enrolled study. The sFLR...
To investigate the expression and clinical significance of ephrin type-A receptor 2 epithelial-mesenchymal transition-related proteins in primary hepatocellular carcinoma.Tissues from 52 carcinomas 12 human normal liver tissues were detected for 2, E-cadherin, N-cadherin by immunochemistry. Cinicopathological features carcinoma tumor recurrence after operation studied association with these molecular expressions E-N cadherin switch.Increased reduced E-cadherin significantly compared tissues....
To investigate the expression and clinical significance of ephrin type-A receptor 2 epithelial-mesenchymal transition-related proteins in primary hepatocellular carcinoma.Tissues from 52 carcinomas 12 human normal liver tissues were detected for 2, E-cadherin, N-cadherin by immunochemistry. Cinicopathological features carcinoma tumor recurrence after operation studied association with these molecular expressions E-N cadherin switch.Increased reduced E-cadherin significantly compared tissues....
The Chinese guidelines for IAI presented here were developed by a panel that included experts from the fields of surgery, critical care, microbiology, infection control, pharmacology, and evidence-based medicine. All questions structured in population, intervention, comparison, outcomes format, evidence profiles generated. Recommendations generated following principles Grading Assessment, Development, Evaluation system or Best Practice Statement (BPS), when applicable. final include 45...
Age at menarche (AAM) and age natural menopause (AANM) have been shown intimately associated with woman's health later in life. Previous studies indicated that AAM AANM are highly heritable. RANKL/RANK/OPG signaling pathway is essential for mammary gland development, which also found post-menopausal hormone-related diseases. The aim of this study was to evaluate associations between the polymorphisms TNFSF11, TNFRSF11A TNFRSF11B genes Chinese women.Post-menopausal women (n = 845) aged from...
To explore the eff ect of Fasudil on invasion and metastatic abilities human high liver cancer cells (HCCLM3) underlying mechanisms.HCCLM3 were incubated with 100 μmol/L Fasudil. Fluorescence staining for F-actin Transwell assay performed to observe ability HCCLM3 cells. divided into 3 groups: a negative control group, group BTB/ POZ domain containing 7 (BTBD7)-siRNA group. Western blot was detect expression levels BTBD7, ras homolog family member C (RhoC) Rho-associated, coiled-coil protein...
CCN gene family members have recently been identified as multifunctional regulators involved in diverse biological functions, especially vascular and skeletal development. In the present study, a comparative genomic phylogenetic analysis was performed to show similarities differences structure function of CCNs from different organisms reveal their potential evolutionary relationship. First, homologs metazoans species were identified. Then we made multiple sequence alignments, MEME analysis,...
Objective: Recent works have demonstrated that neuroepithelial transforming protein 1 (NET-1) gene expression is associated with proliferation, metastasis, and clinical stages of human hepatocellular carcinoma (HCC). To investigate its prognostic significance in HCC, which currently unknown, the authors examined correlation between NET-1 prognosis patients HCC. Methods: Immunohistochemical staining was used to determine level 368 paired HCC normal liver tissue (NLT) specimens. Kaplan–Meier...