A5112127696- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Acute Kidney Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Respiratory Support and Mechanisms
- Anesthesia and Sedative Agents
- Thermal Regulation in Medicine
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related molecular mechanisms research
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Biomarkers in Disease Mechanisms
- Cardiac and Coronary Surgery Techniques
- Lipid metabolism and disorders
- Long-Term Effects of COVID-19
- Inflammation biomarkers and pathways
- COVID-19 Clinical Research Studies
- Neurological Disease Mechanisms and Treatments
- Emergency and Acute Care Studies
First Affiliated Hospital of Xinjiang Medical University
2016-2025
Xinjiang Medical University
2016-2025
Peking Union Medical College Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Anhui Provincial Hospital
2021
Introduction Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology outcome severe septic shock mixed ICU China, as well independent predictors mortality. Methods We performed a 2-month prospective, observational cohort 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during period were screened patients with or included. Results A total 484 patients, 37.3 per 100 diagnosed...
Abstract Background: Ciprofol (HSK3486; Haisco Pharmaceutical Group Co., Ltd., Chengdu, China), developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics propofol when applicated continuous intravenous infusion for 12 h maintenance sedation in previous phase 1 trial. The 2 trial was designed to investigate the safety, efficacy, pharmacokinetic of ciprofol patients undergoing mechanical ventilation. Methods: In this multicenter, open...
OBJECTIVES: To determine the effectiveness and safety of ciprofol for sedating patients in ICUs who required mechanical ventilation (MV). DESIGN: A multicenter, single-blind, randomized, noninferiority trial. SETTING: Twenty-one centers across China from December 2020 to June 2021. PATIENTS: total 135 ICU 18 80 years old with endotracheal intubation undergoing MV, were expected require sedation 6–24 hours. INTERVENTIONS: One hundred thirty-five randomly allocated into ( n = 90) propofol 45)...
We sought to describe the demographics, case mix, interventions, and clinical outcome of critically ill patients admitted ICUs in Mainland China.A 2-month (July 1, 2009, August 31, 2009) prospective, observational cohort study.Twenty-two China.Adult participating during study period with an ICU length stay >24 hrs.None.Patient characteristics, including underlying diseases, severity illness, admission status, complications, intervention treatment stay, were recorded report form. The primary...
Poor inter-rater reliability in chest radiograph interpretation has been reported the context of acute respiratory distress syndrome (ARDS), although not for Berlin definition ARDS. We sought to examine effect training material on accuracy and consistency intensivists' interpretations ARDS diagnosis. conducted a rater agreement study which 286 intensivists (residents 41.3%, junior attending physicians 35.3%, senior physician 23.4%) independently reviewed same 12 radiographs developed by...
Abstract Background Hospital and ICU structural factors are key affecting the quality of care as well patient outcomes. However, data from China scarce. This study was designed to investigate how differences in outcomes associated with hospital structure variables throughout 2019. Methods a multicenter observational study. Data total 2820 hospitals were collected using National Clinical Improvement System that reports information China. collection consisted a) on factors, including type,...
Background Although it has been established that elevated blood pressure and its variability worsen outcomes in spontaneous intracerebral hemorrhage, antihypertensives use during the acute phase still lacks robust evidence. A pressure–lowering regimen using remifentanil dexmedetomidine might be a reasonable therapeutic option given their analgesic antisympathetic effects. The objective of this superiority trial was to validate efficacy safety strategy uses patients with hemorrhage. Methods...
Background Acute kidney injury (AKI) has been recognized as a major healthcare problem affecting millions of patients worldwide. However, epidemiologic data concerning AKI in China are still lacking. The objectives this study were to characterize defined by RIFLE criteria, assess the association with hospital mortality, and evaluate impact context other risk factors. Methods This prospective multicenter observational enrolled 3,063 consecutive from 1 July 2009 31 August 22 ICUs across...
The aim of this study is to develop consensus on core competencies required for postgraduate training in intensive care medicine.We used a combination modified Delphi method and nominal group technique create modify the list ensure maximum consensus. Ideas were generated from Competency Based Training Intensive Care Medicine Europe collaboration (CoBaTrICE) competencies. An online survey invited healthcare professionals, educators, trainees rate comment these output was edited then reviewed...
Abstract Purpose To investigate the effects of ICU quality control indicators on VAP incidence rate and mortality in China throughout 2019. Methods This was a retrospective study. A total 1267 ICUs from 30 provinces mainland were included. Data collected using National Clinical Improvement System that report information. Ten related analyzed, including 5 structural factors (patient-to-bed ratio, physician-to-bed nurse-to-bed patient-to-physician patient-to-nurse ratio), 3 process (unplanned...
Background: Urine output (UO) is an essential criterion of the Kidney Disease Improving Global Outcomes (KDIGO) definition and classification system for acute kidney injury (AKI), which diagnostic value has not been extensively studied. We aimed to determine whether AKI based on KDIGO UO criteria (KDIGOUO) could improve prognostic accuracy, compared with serum creatinine (KDIGOSCr). Methods: conducted a secondary analysis database previous study by China Critical Care Clinical Trial Group...
BACKGROUND: Dexmedetomidine has already been used in septic patients as a new sedative agent, few studies have examined its effects on immunomodulation.Therefore, the authors designed controlled experimental study to characterize immunomodulation of dexmedetomidine cecal ligation and puncture (CLP) model rats. METHODS:After CLP, 48 Wistar rats were randomly allocated into four groups: (1) CLP group;(2) small-dose treatment group (2.5 μg•kg -1 •h ); (3) medium-dose (5.0 • h (4) large-dose...
Liver ischemia/reperfusion injury (I/RI) is characterized by inflammatory actions. Understanding the mechanistic insights underpinning inflammation critical to developing treatment strategies. In this study, we illustrated of transcription factor Yin-Yang 1 (YY1)-mediated microRNA (miR)-181a-5p/estrogen receptor alpha (ESR1)/epidermal growth 2 (ERBB2) axis in liver I/RI.First, established I/RI models mice and hypoxia-reperfusion (H/R) cell mouse hepatocytes (AML12). Subsequently, expression...
Objective: To assess the efficacy and safety of esomeprazole in preventing upper gastrointestinal (GI) bleeding critically ill Chinese patients, using cimetidine as an active comparator.Methods: A pre-specified non-inferiority limit (5%) was used to compare rates significant GI this randomized, double-blind, parallel-group, phase 3 study across 27 intensive care units China. Secondary endpoints included tolerability measures. Patients required mechanical ventilation had at least one...
Sepsis is a major challenge in critical care and associated with high mortality. Current management of sepsis septic shock remains mainly supportive. Both basic clinical research has shown that ulinastatin can improve the prognosis sepsis. The aim this trial to evaluate efficacy safety profiles compared placebo. In multi-center, double-blind, randomized placebo-controlled we are recruiting total 348 subjects meeting "The Third International Consensus Definitions for Septic Shock" (Sepsis-3)....
Sepsis is a global public health burden. The sequential organ failure assessment (SOFA) the most commonly used scoring system for diagnosing sepsis and assessing severity. Due to widespread use of endotracheal intubation sedative medications in sepsis, accuracy Glasgow Coma Score (GCS) lowest SOFA. We designed this multicenter, cross-sectional study investigate predictive efficiency SOFA with or without GCS on ICU mortality patients sepsis.
Sepsis is a disease that typically treated in intensive care units with high mortality and morbidity. Pyroptosis newly identified type of programmed cell death characterized by inflammatory cytokine secretion. However, the role pyroptosis sepsis remains unclear.