Zhaoxiang Li

ORCID: 0009-0003-8255-433X
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Research Areas
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Advanced Photocatalysis Techniques
  • Crystallization and Solubility Studies
  • Quantum Dots Synthesis And Properties
  • X-ray Diffraction in Crystallography
  • Conducting polymers and applications
  • TiO2 Photocatalysis and Solar Cells
  • Cancer-related molecular mechanisms research
  • Network Security and Intrusion Detection
  • Nanocluster Synthesis and Applications
  • Aortic aneurysm repair treatments
  • Peptidase Inhibition and Analysis
  • Polydiacetylene-based materials and applications
  • Genomics and Phylogenetic Studies
  • Supramolecular Chemistry and Complexes
  • Microbial Applications in Construction Materials
  • Microbial Natural Products and Biosynthesis
  • Chemical Synthesis and Analysis
  • Cytokine Signaling Pathways and Interactions
  • Organic Electronics and Photovoltaics
  • Infections and bacterial resistance
  • Anomaly Detection Techniques and Applications
  • Supramolecular Self-Assembly in Materials
  • Plasmonic and Surface Plasmon Research
  • Nuclear Receptors and Signaling

First Hospital of China Medical University
2025

China Medical University
2025

Zhengzhou University
2021-2024

Yanbian University
2022-2024

Yunnan University
2022-2024

East University Of Heilongjiang
2022-2023

Harbin University of Science and Technology
2023

Changchun University of Science and Technology
2023

Capital Medical University
2022

Ministry of Education of the People's Republic of China
2022

Abstract Regulation of hot spots exhibits excellent potential in many applications including nanolasers, energy harvesting, sensing, and subwavelength imaging. Here, hat-shaped hierarchical nanostructures with different space curvatures have been proposed to enhance for facilitating surface-enhanced Raman scattering (SERS) plasmon-driven catalysis applications. These novel comprise two layers metal nanoparticles separated by MoS 2 films. The fabrication this hybrid structure is based on the...

10.1515/nanoph-2021-0476 article EN cc-by Nanophotonics 2021-11-12

MoS2-based heterostructures have received increasing attention for not only surface-enhanced Raman scattering (SERS) but also enhanced photoelectrocatalytic (PEC) performance. This study presents a hydrothermal method preparing vertical MoS2 nanosheets composed of in situ grown AuNPs with small size and chemically reduced AgNPs large to achieve the synergistic enhancement SERS PEC properties owing effect plasmonic structure. Compared pristine unitary or composited nanosheets, ternary...

10.1364/oe.441176 article EN cc-by Optics Express 2021-10-29

Background Alzheimer’s disease (AD) is a common, refractory, progressive neurodegenerative disorder in which cognitive and memory deficits are highly correlated with abnormalities hippocampal brain regions. There still lack of hippocampus-related markers for AD diagnosis prevention. Methods Differently expressed genes were identified the gene expression profile GSE293789 region. Enrichment analyses GO, KEGG, GSEA used to identify biological pathways involved DEGs AD-related group. WGCNA was...

10.3389/fnins.2024.1359631 article EN cc-by Frontiers in Neuroscience 2024-03-07

Background Chronic critical illness (CCI) can manifest as dysfunction of thyroid hormones. This study aimed to investigate the predictive value nonthyroidal syndrome (NTIS) for prognosis CCI patients, establish a model and evaluate efficacy provide theoretical basis clinical intervention.

10.1080/07853890.2025.2479583 article EN cc-by Annals of Medicine 2025-03-21

The weak plasmonic coupling intensity in an aluminum (Al) nanostructure has limited potential applications excellent low-cost surface-enhanced Raman scattering (SERS) substrates and light harvesting. In this report, we aim to elevate the by fabricating Al nanoparticle (NP)−film system. system, NP are fabricated directly on different film layers, nanoscale-thick alumina interlayer obtained between neighboring films acts as natural dielectric gaps. Interestingly, number of layers increase,...

10.1364/oe.389886 article EN cc-by Optics Express 2020-03-06

Tumor angiogenesis is critical for tumor metastasis by providing oxygen, nutrients, and metastatic pathways. As a potential anti-angiogenic agent, Dihydroartemisinin (DHA) can effectively inhibit metastasis. However, the mechanism how it regulates to affect has not been fully clarified. To investigate mechanisms of DHA melanoma progression. In this study, bioinformatics methods were used analyze correlation between Then, B16F10, A375, HUVECs mouse models adapted clarify inhibition in...

10.1002/ptr.8065 article EN cc-by-nc-nd Phytotherapy Research 2023-11-19

Psoriasis is a chronic, prolonged, and recurrent inflammatory skin disease the current therapeutics can only alleviate symptoms rather than cure it completely. Therefore, we aimed to identify molecular signatures specific biomarkers of psoriasis provide novel clues for targeted therapy. In present study, Gene Expression Omnibus (GEO) database was used retrieve three microarray datasets (GSE166388, GSE50790 GSE42632) explore differentially expressed genes (DEGs) in using Affy package R...

10.3390/ijms232315286 article EN International Journal of Molecular Sciences 2022-12-04

Diabetic foot ulcer (DFU) is a frequently diagnosed complication of diabetes, and remains heathcare burden worldwide. However, the pathogenesis DFU still largely unclear. The objective this study to delineate function underlying mechanism lncRNA antisense non coding RNA in INK4 locus (ANRIL) endothelial progenitor cells (EPCs) mice.The mouse model was established, EPCs were subjected high glucose (HG) treatment mimic diabetes. qRT-PCR or western blot employed detected expression ANRIL,...

10.1002/jgm.3462 article EN The Journal of Gene Medicine 2022-11-08

The simultaneous output of highly sensitive and reproducible signals for surface-enhanced Raman spectroscopy (SERS) technology remains difficult. Here, we propose a two-dimensional (2D) composite structure using the repeated annealing method with MoS 2 film as molecular adsorbent. This provides enlarged Au nanoparticle (NP) density much smaller gap spacing, thus dramatically increases intensity hot spots. films distribute among spots, which is beneficial uniform adsorption, further...

10.1364/oe.403940 article EN cc-by Optics Express 2020-09-09

As a metastasis-prone malignancy, the metastatic form and location of melanoma seriously affect its prognosis. Although effective surgical methods targeted drugs are available to enable treatment carcinoma in situ, for tumors, diagnosis, prognosis assessment development immunotherapy still pending. This study aims integrate multiple bioinformatics approaches identify immune-related molecular targets viable prognostic melanoma, thus providing new strategies use as an immunotherapy....

10.3390/ijms241813752 article EN International Journal of Molecular Sciences 2023-09-06

Abstract PRAS40 has been shown to have a crucial role in the repression of mammalian target rapamycin (mTOR). Nonetheless, appears an oncogenic function cancer cells. Whether mediates signaling independent mTOR inhibition cells remains elusive. Here overexpression lung adenocarcinoma and cutaneous melanoma was significantly correlated worse prognosis. And we identified unexpected for regulation nuclear factor (NF)-κB signaling. P65, subunit NF-κB transcription complex, confirmed associate...

10.1038/oncsis.2017.80 article EN cc-by Oncogenesis 2017-09-25

Combination chemotherapy is recognized as a vital medical treatment for cancer, but it has not achieved clinical ideal effects of combination therapy. Herein, we designed supramolecular strategy based on cucurbit[8]uril (CB[8]), which can be facilely assembled into dual platinum drugs. Interestingly, employing the CB[8] carrier led to greater than 10-fold intracellular Pt content compared that drugs at 4 h, and complex (CLE) enhance infiltration in colorectal tumor cells tremendously. The...

10.1021/acs.langmuir.2c02388 article EN Langmuir 2022-11-10

The rhenium disulphide (ReS 2 ) nanocavity-based surface enhanced Raman scattering (SERS) substrates ware fabricated on the gold-modified silicon pyramid (PSi) by thermal evaporation technology and hydrothermal method. In this work, ReS nanocavity was firstly combined with metal nanostructures in order to improve SERS properties of materials, response composite structure exhibits excellent performance sensitivity, uniformity repeatability. Numerical simulation reveals synergistic effect...

10.1364/oe.435627 article EN cc-by Optics Express 2021-08-16

The present study aimed to analyze the impact of astragaloside IV (AS-IV) on abdominal aortic aneurysm (AAA) and glycocalyx, elucidating potential mechanism AS-IV.

10.1155/2024/2348336 article EN cc-by Analytical Cellular Pathology 2024-02-13

MoS2-plasmonic hybrid platforms have attracted significant interest in surface-enhanced Raman scattering (SERS) and plasmon-driven photocatalysis. However, direct contact between the metal MoS2 creates strain that deteriorates electron transport across metal/ interfaces, which would affect SERS effect catalytic performance. Here, MoS2/graphene van der Waals heterojunctions (vdWHs) were fabricated combined with two-layered gold nanoparticles (Au NP) for photocatalysis analyse. The graphene...

10.1364/oe.443835 article EN cc-by Optics Express 2021-10-22

EDOT–<italic>CH</italic>(<italic>R</italic>)–EDOT was chosen as a prototype model monomer for solid state polymerization (SSP). The aromatic moieties were first introduced in the branch chain polymer matrix.

10.1039/c5ra21122k article EN RSC Advances 2015-01-01
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