A5083775832- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Aquaculture disease management and microbiota
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Enzyme-mediated dye degradation
- Cardiac tumors and thrombi
- Ovarian cancer diagnosis and treatment
- Analytical chemistry methods development
- PARP inhibition in cancer therapy
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
- Signaling Pathways in Disease
- Tissue Engineering and Regenerative Medicine
- Chromium effects and bioremediation
- Neuroblastoma Research and Treatments
University of California, Los Angeles
2018-2023
Doshisha Women's College of Liberal Arts
2022
Abstract Loss of function the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark clear cell renal carcinoma (ccRCC). The importance heterogeneity in loss this has been under reported. To study impact intratumoral VHL observed human ccRCC, we engineered deletion four RCC models, including new primary line derived from an aggressive metastatic case. gene-deleted (VHL-KO) cells underwent epithelial-to-mesenchymal transition (EMT) and exhibited increased motility but diminished...
M2 macrophages in the tumor microenvironment are important drivers of cancer metastasis. Exosomes play a critical role crosstalk between different cells by delivering microRNAs or other cargos. Whether exosomes derived from pro-tumorigenic (M2-Exos) could modulate metastatic behavior renal cell carcinoma (RCC) is unclear. This study found that M2-Exos promotes migration and invasion RCC cells. Inhibiting miR-21-5p significantly reversed their pro-metastatic effects on vitro avian embryo...
Cancer of the urological system commonly occurs in kidney, bladder, and prostate gland. The clear cell subtype renal carcinoma (ccRCC) constitutes great majority kidney cancer. Metastatic ccRCC portends a very poor outcome with no effective treatment available. Prostate cancer is most common males US. Despite recent advances selective kinase inhibitors immunotherapies, rate developing new from bench to bedside slow. A time-consuming step at animal drug testing stage, which mouse model gold...
Mouse models are the benchmark tests for in vivo cancer studies. However, cost, time, and ethical considerations have led to calls alternative models. The chicken chorioallantoic membrane (CAM) model provides an inexpensive, rapid that permits direct visualization of tumor development is suitable imaging. As such, we sought develop optimized protocol engrafting gynecological urological tumors into this model, which present here. Approximately 7 days postfertilization, air cell moved...
Poly(ADP-ribosyl)ation is a post-translational modification of proteins by transferring poly(ADP-ribose) (PAR) to acceptor the action polymerase (PARP). Two tankyrase (TNKS) isoforms, TNK1 and TNK2 (TNKS1/2), are ubiquitously expressed in mammalian cells participate diverse cellular functions, including wnt/β-catenin signaling, telomere maintenance, glucose metabolism mitosis regulation. For TNKS1/2 catalyze poly(ADP-ribosyl)ation Axin, key component β-catenin degradation complex, which...
Exosomes are extracellular vesicles that modulate essential physiological and pathological signals. Communication between cancer cells express the von Hippel-Lindau (VHL) tumor suppressor gene those do not is instrumental to distant metastasis in renal cell carcinoma (RCC). In a novel model, VHL(−) metastatic driver, while VHL(+) receive signals from undergo aggressive transformation. This study investigates whether exosomes could be mediating crosstalk. isolated paired lines were assessed...
Metastatic clear cell renal carcinoma (ccRCC) is the most common subtype of kidney cancer. Localized ccRCC has a favorable surgical outcome. However, one third patients will develop metastases to lung, which related very poor outcome for patients. Unfortunately, no therapy available this deadly stage, because molecular mechanism metastasis remains unknown. It been known 25 years that loss function von Hippel-Lindau (VHL) tumor suppressor gene pathognomonic ccRCC. clinically relevant...
Metastatic clear cell renal carcinoma (ccRCC) is the most common subtype of kidney cancer. Localized ccRCC has a favorable surgical outcome. However, one third patients will develop metastases to lung, which related very poor outcome for patients. Unfortunately, no therapy available this deadly stage, because molecular mechanism metastasis remains unknown. It been known 25 years that loss function von Hippel-Lindau (VHL) tumor suppressor gene pathognomonic ccRCC. clinically relevant...
Mouse models are the benchmark tests for in vivo cancer studies. However, cost, time, and ethical considerations have led to calls alternative models. The chicken chorioallantoic membrane (CAM) model provides an inexpensive, rapid that permits direct visualization of tumor development is suitable imaging. As such, we sought develop optimized protocol engrafting gynecological urological tumors into this model, which present here. Approximately 7 days postfertilization, air cell moved...
Abstract BACKGROUND: Despite the advancement of targeted therapies and immunotherapies, outcome clear cell renal carcinoma (ccRCC) remains poor at metastatic stage, with a median survival mere 7 months. This devastating is partially due to an inadequate understanding mechanism ccRCC. Previously, we found that two distinct populations co-exist in malignancy: one functional von-Hippel Lindau (VHL) gene (VHL(+)) other without (VHL(-)). heterogeneity VHL plays essential role, where VHL(-) cells...
Immunotherapy represents an exciting new strategy to treat patients with malignant gliomas; however, we and others have previously shown that the presence of other immune cell populations in tumor microenvironment can reduce effectiveness immunotherapy. To date, a comprehensive quantitative examination composition glioma has not been performed. We purified CD45+ cells from freshly digested samples 35 undergoing surgical resection at UCLA performed CyTOF mass cytometry. then analyzed lineage...
Abstract Clear cell renal carcinoma (ccRCC) is the most common subtype of kidney cancers. Annually, 74,000 Americans are newly diagnosed with disease, and more than 14,000 patients succumb to death, especially due advanced-stage ccRCC developing distant metastases. Unfortunately, there currently no effective therapy for deadly stage. Despite recent progress in immunotherapy or anti-angiogenesis kinase inhibitors, efficacy varies from one patient another. Therefore, gaining further insight...
Abstract To study the impact of intratumoral VHL heterogeneity observed in patient ccRCC primary tumors, we engineered gene deletion three RCC models, including a new tumor cell line derived from an aggressive metastatic ccRCC. The gene-deleted (VHL-KO) cells underwent epithelial-to-mesenchymal transition (EMT) and showed diminished proliferation tumorigenicity compared to parental, VHL-expressing (VHL+) cells. Renal tumors with either VHL+ or VHL-KO alone exhibit minimal potential....