A5010511707- Neuroinflammation and Neurodegeneration Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Nanoplatforms for cancer theranostics
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- RNA Interference and Gene Delivery
- Ferroelectric and Piezoelectric Materials
- Cell death mechanisms and regulation
- Radiopharmaceutical Chemistry and Applications
- Multiferroics and related materials
- Neuropeptides and Animal Physiology
- Atherosclerosis and Cardiovascular Diseases
- Microwave Dielectric Ceramics Synthesis
- Cancer, Lipids, and Metabolism
- Neuroscience and Neuropharmacology Research
- Prostate Cancer Treatment and Research
- Melanoma and MAPK Pathways
- Advanced Nanomaterials in Catalysis
- CRISPR and Genetic Engineering
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Hormonal Regulation and Hypertension
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Genital Health and Disease
China Pharmaceutical University
2014-2025
University of Lübeck
2012-2025
University Hospital Schleswig-Holstein
2012-2025
Guangdong Medical College
2023-2025
University of Wisconsin–Madison
2019-2024
State Key Laboratory of Electrical Insulation and Power Equipment
2022-2024
Sun Yat-sen University
2022-2024
Hunan University of Science and Technology
2024
Xi'an Jiaotong University
2020-2024
Clinical Research Center Kiel
2023
Antimicrobial resistant (AMR) infections are a growing threat to public health and there is general lack of development in new antibiotics. Here, dextran-coated stimuli-responsive nanoparticle (NP) that encapsulates the hydrophobic antibiotic, rifampicin, specifically binds bacteria overcome AMR reported. The NP shows strong affinity with variety pathogens vitro effectively accumulates bacterial infected tissues. activated by either low pH or high reactive oxygen species infectious...
Up-regulation of cyclooxygenase (COX)-2 exacerbates neuronal injury after cerebral ischemia and contributes to cell death. The present study clarifies the function peroxisome-proliferator-activated receptor(s) gamma (PPARgamma) in expression COX-2 neurons rat brain middle artery occlusion (MCAO) with reperfusion by immunohistochemistry, Western blot, immunofluorescence staining. In peri-infarct cortical areas PPARgamma was located both microglia neurons, whereas almost exclusively expressed...
Abstract An urgent need for developing new antimicrobial approaches has emerged due to the imminent threat of antimicrobial‐resistant (AMR) pathogens. Bacterial infection can induce a unique microenvironment with low pH, which be employed trigger drug release and activation. Here, pH‐responsive polymer–drug conjugate (PDC) capable combating severe infectious diseases overcoming AMR is reported. The PDC made biodegradable biocompatible cationic polymer Hex‐Cys‐DET streptomycin, model...
Nanoparticle-based therapeutics represent potential strategies for treating atherosclerosis; however, the complex plaque microenvironment poses a barrier nanoparticles to target dysfunctional cells. Here, we report reactive oxygen species (ROS)-responsive and size-reducible nanoassemblies, formed by multivalent host-guest interactions between β-cyclodextrins (β-CD)-anchored discoidal recombinant high-density lipoprotein (NP3ST) hyaluronic acid-ferrocene (HA-Fc) conjugates. The HA-Fc/NP3ST...
Clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 (Cas9) may offer new therapeutics for genetic diseases through gene disruption via nonhomologous end joining (NHEJ) or correction homology-directed repair (HDR). However, clinical translation of CRISPR technology is limited by the lack safe and efficient delivery systems. Here, facilely fabricated pH-responsive polymer nanoparticles capable safely efficiently delivering Cas9 ribonucleoprotein alone (termed...
Hyaluronic-acid (HA)-coated LOX-1-specific siRNA-condensed cell-penetrating peptide (CPP) nanocomplexes (NCs) were developed for targeted gene delivery to macrophages and suppression of lipid accumulation. The HA coating facilitated the accumulation nanoparticles at leaky endothelium overexpressing CD44 receptors was further degraded by hyaluronidase (HAase) intraplaques exposing naked CPP NCs achieving ultimate location into macrophages. surface verified increased particle size, inverted...
Ultrasonic energy harvesting technologies have gained much attention for biomedical applications due to their several desirable features including low-energy attenuation and strong penetration capability. In this work, flexible piezoelectric poly(vinylidenefluoride-co-trifluoroethylene) (P(VDF-TrFE))/barium titanate (BaTiO3, BT) membranes, capable of converting ultrasound electric energy, were fabricated by an electrospinning process effects on the wound healing behaviors with/without...
Occlusion of blood vessels caused by thrombi is the major pathogenesis various catastrophic cardiovascular diseases. Thrombi can be prevented or treated antithrombotic drugs. However, free drugs often have relatively low therapeutic efficacy due to a number limitations such as short half-life, unexpected bleeding complications, thrombus targeting capability, and negligible hydrogen peroxide (H2O2)-scavenging ability. Inspired abundance H2O2 active thrombus-targeting property platelets,...
Introduction As a deadly disease induced by Mycobacterium tuberculosis (Mtb), remains one of the top killers among infectious diseases. The low intracellular Mtb killing efficiency current antibiotics introduced long duration anti-TB therapy in clinic with strong side effects and increased drug-resistant mutants. Therefore, exploration novel agents potent becomes most urgent issues for TB therapies. Methods Here, we firstly method preparation zinc oxide-selenium nanoparticles (ZnO-Se NPs)...
Abstract The present study addresses the neuroprotective function of intracerebroventricular (i.c.v.) application pioglitazone, a selective ligand peroxisome proliferator‐activated receptor gamma (PPARγ) in rat brain after ischaemia. Pioglitazone or vehicle were i.c.v. infused via osmotic minipumps over 5‐day period before, and 2 days transient middle cerebral artery occlusion (MCAO) for 90 min. This pioglitazone significantly reduced infarct size oedema, attenuated peri‐infarct cortical...
Recreating the 3D cyst-like architecture of alveolar epithelium in vitro has been challenging to achieve a controlled fashion with primary lung epithelial cells. Here, we demonstrate model alveoli formed within tunable synthetic biomaterial platform using photodegradable microspheres as templates create physiologically relevant, cyst structures. Poly(ethylene glycol) (PEG)-based hydrogels were polymerized suspension form on order 120 μm diameter. The gel chemistry was designed allow erosion...