A5045032364- Radiopharmaceutical Chemistry and Applications
- Bone health and treatments
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Boron Compounds in Chemistry
- RNA modifications and cancer
- MicroRNA in disease regulation
- Prostate Cancer Treatment and Research
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Immune cells in cancer
- Wnt/β-catenin signaling in development and cancer
- Pharmacological Effects of Natural Compounds
- Genetics, Aging, and Longevity in Model Organisms
- Helicobacter pylori-related gastroenterology studies
- Medicinal Plants and Bioactive Compounds
- Circular RNAs in diseases
- Toxin Mechanisms and Immunotoxins
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2022-2024
Guangzhou University of Chinese Medicine
2024
Nanjing University of Chinese Medicine
2024
Shuguang Hospital
2021-2023
Shanghai University of Traditional Chinese Medicine
2021-2023
Abstract: The utilization of PD-1/PD-L1 inhibitors marks a significant advancement in cancer therapy. However, the efficacy monotherapy is still disappointing substantial subset patients, necessitating exploration combinational strategies. Emerging from promising results KEYNOTE-942 trial, RNA-based therapies, particularly circRNAs and piRNAs, have distinguished themselves as innovative sensitizers to immune checkpoint (ICIs). These non-coding RNAs, notable for their stability specificity,...
Abstract Background Non‐apoptotic cell death is presently emerging as a potential direction to overcome the apoptosis resistance of cancer cells. In current study, natural plant agent α‐hederin (α‐hed) induces caspase‐independent paraptotic modes death. Purpose The present study aimed investigate role α‐hed paraptosis and associated mechanism it. Methods proliferation was detected by CCK‐8. cytoplasm organelles were observed under electron microscope. Calcium (Ca 2+ ) level flow cytometry....
Helicobacter pylori (H. pylori) is a carcinogenic factor for gastric cancer. Our previous study demonstrated that H. decreased the expression of micro-RNA (miRNA)-30a to promote tumorigenesis However, upstream regulatory molecules miR-30a are not well elucidated. In this study, we found long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) may sponge regulate COX-2/BCL9 pathway.The NEAT1 was detected in cancer tissues and tumor-adjacent by fluorescence situ...
Bone is the most common site of metastasis prostate cancer (PCa). PCa invasion leads to a disruption osteogenic-osteolytic balance and causes abnormal bone formation. The interaction between stromal cells, especially osteoblasts (OB), considered essential for disease progression. However, drugs that effectively block cancer-bone regulate remain undiscovered.A reporter gene system was constructed screen compounds could inhibit PCa-induced OB activation from 631 compounds. Then,...
Abstract Background Helicobacter pylori ( H. ) accounts for the majority of gastric cancer (GC) cases globally. The present study found that promoted GC stem cell (CSC)‐like properties, therefore, regulatory mechanism how promotes stemness was explored. Methods Spheroid‐formation experiments were performed to explore self‐renewal capacity cells. expression R‐spondin 3 (RSPO3), Nanog homeobox, organic cation/carnitine transporter‐4 (OCT‐4), SRY‐box transcription factor 2 (SOX‐2), CD44, Akt,...
Abstract Background: Helicobacter pylori (H. pylori) is a carcinogenic factor for gastric cancer. Our previous study demonstrated that H. decreased the expression of microRNA(miRNA)-30a to promote tumorigenesis in However, upstream regulatory mechanism miR-30a hasn’t well-elucidated. In this study, we found long non‑coding RNA (lncRNA) NEAT1 may sponge regulate COX-2/BCL9 pathway. Methods: The was detected cancer tissues and tumour adjacent by fluorescence in-situ hybridization(FISH)...