A5053492603- Ferroptosis and cancer prognosis
- Gastrointestinal motility and disorders
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds in Plants
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- Phytochemicals and Antioxidant Activities
- Endoplasmic Reticulum Stress and Disease
- Berberine and alkaloids research
- Adenosine and Purinergic Signaling
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Mast cells and histamine
- Cytokine Signaling Pathways and Interactions
- Sirtuins and Resveratrol in Medicine
- Flavonoids in Medical Research
- Cancer, Lipids, and Metabolism
- Digestive system and related health
- Barrier Structure and Function Studies
- Pineapple and bromelain studies
First Affiliated Hospital of Dalian Medical University
2016-2024
Dalian Medical University
2014-2024
Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract. Citrus nobiletin can exert robust anti-inflammatory effects in vivo and vitro. We evaluated impact on excessive response impaired barrier function rodent colitis model.Colitis was established by infusion with 1 mL 2,4,6-trinitrobenzene sulfonic acid (TNBS) dissolved ethanol (40% v/v) rats at 125 mg/kg dose. Caco-2 cell monolayer exposed to LPSs used as culture model for intestinal permeability...
Shaoyao Decoction (SYD) is a canonical herbal medicine prescription formulated by Liu Wan-Su in AD 1186. SYD has been widely used to treat inflammatory bowel disease clearing heat and damp, removing stasis toxin the intestine; however, precise mechanisms therapeutic material basis remain largely unclear. In present study, we measured effects of on colitis symptom, epithelial barrier function, ferroptosis, colonic protein mRNA expression glutathione peroxidase 4 (GPX4) model, determined...
Inhibition of ferroptosis in intestinal epithelial cells ameliorates clinical symptoms and improves endoscopic presentations inflammatory bowel disease (IBD). Licorice is used worldwide food medicine fields. Liquiritin, a flavonoid component licorice, an effective substance as anti-inflammatory, antioxidant that has been shown to improve chemically induced colitis. Herein we evaluated the therapeutic effects liquiritin on colitis determined whether could affect by modulating cells. A model...
Intestinal disorders often co-occur with inflammation and dysmotility. However, drugs which simultaneously improve intestinal co-occurring dysmotility are rarely reported. Atractylodin, a widely used herbal medicine, is to treat digestive disorders. The present study was designed characterize the effects of atractylodin on amelioration both jejunal in constipation-prominent (CP) diarrhea-prominent (DP) rats. results indicated that reduced proinflammatory cytokines TNF-α, IL-1β, IL-6 plasma...
Salvianolic acid B (Sal B) is isolated from the traditional Chinese medical herb Salvia miltiorrhiza and reported to have a wide range of therapeutic benefits. The aim this study was investigate effects Sal on epithelial barrier dysfunction in rat inflammatory bowel disease (IBD) uncover related mechanisms. Rat IBD model established by intracolonic administration 2, 4, 6-trinitrobenzene sulfonic (TNBS). intestinal function evaluated measuring serum recovery fluorescein isothiocyanate-4 kD...
Inhibition of ferroptosis in intestinal epithelial cells serves as an attractive target for the development therapeutic strategies colitis. Pinobanksin, one main flavonoids derived from propolis, possesses significant anti-inflammatory effects and inhibits cell death several lines. Here, we evaluated whether pinobanksin influenced colitis by modulation ferroptosis. Mice treated with 2.5% DSS dissolved sterile distilled water were established acute model. The mitochondrial morphology, colonic...
Emodin is traditionally used as a laxative and found to increase or decrease the contractility of intestinal smooth muscle in low doses high doses, respectively. In this study, we propose that bidirectional regulation (BR) on jejunal (CJSM) inducible by emodin absence control central nervous system. The results indicated emodin-induced BR had following characteristics. A stimulatory effect CJSM was induced at 7 contractile states, an inhibitory states. Emodin-induced myosin phosphorylation...
Activation of the TNF-α receptor (TNFR) leads to an inflammatory response, and anti-TNF therapy has been administered reduce inflammation symptoms heal mucosal ulcers in bowel disease (IBD). Bromelain, a complex natural mixture proteolytic enzymes, shown exert anti-inflammatory effects. This study aimed investigate effect purified fruit bromelain (PFB)-induced inhibition epithelial TNFR rat colitis model. Colitis was established by intracolonic administration 2, 4, 6-trinitrobenzene sulfonic...
Naringin has been shown to exert protective effects in an animal model of ulcerative colitis, but detailed mechanisms remain unclear. This study aimed investigate function and signaling underlying naringin-induced therapeutic on colitis. Two mouse models were established mimic human Inflammatory bowel disease (IBD) by treating drinking water with dextran sodium sulphate or intra-colonic administration 2, 4, 6-trinitrobenzene sulfonic acid. Transcriptomics combined functional experiments used...
Activation of phosphatase and tensin homolog (PTEN) is known to induce cell apoptosis. MicroRNA-374a (miR-374a), which can suppress PTEN expression, has been found abnormally expressed in inflammatory bowel disease (IBD). Fortunellin a citrus flavonoid that potential anti-inflammation agent diseases. The present study investigated the effects mechanisms underlying fortunellin-induced inhibition IBD. Colitis was established rats by intracolonic administration 2,4,6-trinitrobenzene sulfonic...
Capsaicin is an active component of chili peppers, having diverse effects. However, the effects capsaicin on intestinal motility are still controversial. The present study aimed to investigate disorder and uncover related mechanisms.A rat model with was established in vitro through adding different stimuli into tissue bath; vivo using constipation diarrhea model, respectively. exerted dual motility, i.e. relaxation contraction jejunum induced by corresponding stimulus were, respectively,...
Regulatory T (Treg) cells is required to dampen immune responses against intestinal microbiota, which aid in a healthy body promise that the resident gut microbiota should not attract attention of system. Inflammation and inflammatory bowel disease (IBD) can be induced if system fails ignore targets them instead. D-mannose, common monosaccharide nature, has been shown ameliorate multiple autoimmune diseases. This study aimed investigate therapeutic effect D-mannose on mice ulcerative colitis...
Abstract Objectives The aim of the study was to evaluate berberine-induced bidirectional regulation on contractility jejunum. Methods Different low and high contractile states isolated jejunal segment from rat were established investigate effects berberine. Key findings Stimulatory exerted by berberine in six inhibitory produced states. myosin light chain kinase (MLCK) mRNA expression, MLCK protein content, phosphorylation jejunum also bidirectional. Bidirectional not observed presence...
Madagascine (3-isopentenyloxyemodin) can be chemically synthesized or purified from several Rhamnus species, and it is found to have more potent biological activities than the parent compound emodin. The aim of this study characterize vasodilatory effect madagascine on vasoconstriction sphingosylphosphorylcholine induced vasospasm in ex vivo reveal potential mechanisms vitro. effects rat mesenteric resistance arteries (MRAs) by K+, methoxamine, endothelin-1 were respectively studied....
This study was designed to characterise the effects of evodiamine on intestinal contractility and reveal correlated mechanisms. Evodiamine (2.5–80.0 μM) increased normal jejunal hypocontractility established under a variety experimental conditions. Evodiamine-exerted stimulatory were blocked by L-type Ca2+ channel blocker nifedipine or abolished in Ca2+-free assay condition. The partially presence neurotoxin tetrodotoxin endogenous acetylcholine synthesis hemicholinium-3 muscarinic receptor...