A5100336199- Plant-derived Lignans Synthesis and Bioactivity
- Gastrointestinal motility and disorders
- Phytochemical Studies and Bioactivities
- Curcumin's Biomedical Applications
- Cardiac Ischemia and Reperfusion
- Advanced Glycation End Products research
- Neuroblastoma Research and Treatments
- Natural product bioactivities and synthesis
- Carbohydrate Chemistry and Synthesis
- Phytochemistry and biological activity of medicinal plants
- Coenzyme Q10 studies and effects
- Medicinal Plants and Neuroprotection
- Ginger and Zingiberaceae research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bioactive Compounds in Plants
- Lymphatic System and Diseases
- Berberine and alkaloids research
- Biochemical and Molecular Research
- Axon Guidance and Neuronal Signaling
- Helicobacter pylori-related gastroenterology studies
- Alkaloids: synthesis and pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Neuroendocrine Tumor Research Advances
- Immune cells in cancer
- Eicosanoids and Hypertension Pharmacology
Dalian Medical University
2012-2020
RIKEN
2015
Zhejiang University
2011
Yangzhou University
2004
Intestinal disorders often co-occur with inflammation and dysmotility. However, drugs which simultaneously improve intestinal co-occurring dysmotility are rarely reported. Atractylodin, a widely used herbal medicine, is to treat digestive disorders. The present study was designed characterize the effects of atractylodin on amelioration both jejunal in constipation-prominent (CP) diarrhea-prominent (DP) rats. results indicated that reduced proinflammatory cytokines TNF-α, IL-1β, IL-6 plasma...
Emodin is traditionally used as a laxative and found to increase or decrease the contractility of intestinal smooth muscle in low doses high doses, respectively. In this study, we propose that bidirectional regulation (BR) on jejunal (CJSM) inducible by emodin absence control central nervous system. The results indicated emodin-induced BR had following characteristics. A stimulatory effect CJSM was induced at 7 contractile states, an inhibitory states. Emodin-induced myosin phosphorylation...
It is well known that the “free” form of glycans are structurally related to asparagine (N)-linked (“free N-glycans”) found in a wide variety organisms. The mechanisms responsible for formation/degradation high mannose-type free N-glycans have been extensively studied mammalian cells. Recent evidence, however, also suggests sialylated, complex-type present cytosol various mammalian-derived cultured cells/tissues. We report herein on an investigation mechanism degradation such sialyl...
Abstract Objectives The aim of the study was to evaluate berberine-induced bidirectional regulation on contractility jejunum. Methods Different low and high contractile states isolated jejunal segment from rat were established investigate effects berberine. Key findings Stimulatory exerted by berberine in six inhibitory produced states. myosin light chain kinase (MLCK) mRNA expression, MLCK protein content, phosphorylation jejunum also bidirectional. Bidirectional not observed presence...
Saccharides from Arctium lappa. L. root (ALR-S) is a high-purity fructosaccharide separated the medicinal plant root. These compounds showed many pharmacological effects in previous studies. In present study, antithrombotic of ALR-S arterial thrombosis via inhibiting platelet adhesion and rebalancing thrombotic factor expression secretion were found rats human aortic endothelial cells (HAECs). This study also that inhibition oxidative stress (OS), which closely involved coagulation-...
The aim of this study was to characterize and reveal the protective effects cinnamaldehyde (CA) against mesenteric ischemia-reperfusion- (I/R-) induced lung liver injuries related mechanisms. Sprague-Dawley (SPD) rats were pretreated for three days with 10 or 40 mg/kg/d, ig CA, then ischemia 1 h reperfusion 2 h. results indicated that pretreatment mg/kg CA attenuated morphological damage in both tissues I/R-injured rats. significantly restored levels aspartate transaminase (AST) alanine...
1. Resibufogenin (1), a major bufadienolide of Chinese medicine Chan Su, had wide range pharmacological activities. In present work, the metabolism 1 in male Sprague-Dawley rats was investigated by identifying metabolites resibufogenin excreted rat bile.2. Following an oral dose 60 mg/kg resibufagenin, nine were isolated from bile rats, and their structures identified as 3-keto- (2), 3-epi-resibufogenin (3), 5β-hydroxy-3-epi-resibufogenin (4), 1α, 5β-dihydroxy-3-epi-resibufogenin (5), 3α,...
Context: Ginsenosides are primary active ingredients of ginseng, which believed to have various health benefits. It is found that the biotransformation ginsenosides mainly takes place in gastrointestinal tract and information about ginsenosides-exerted effects on intestinal contractility not sufficient.Aims: The present study proposed could exert stimulatory or inhibitory motility depending assay condition-related contractile states was characterize motility.Methods: Jejunal determination,...
In this study, two new compounds and six known were isolated from the aerial parts of Pteris semipinnata. The chemical structures these elucidated as 6β,11α-dihydroxy-15-oxo-ent-kaur-16-en-19-oic acid (1) 7α,11α-dihydroxy-15-oxo-ent-kaur-16-en-19-oic (2) by extensive spectral methods including 2D NMR HR-MS techniques.
High exposure to advanced glycation end-products (AGEs) may induce cardiotoxicity. However, the effects and mechanisms remain be further clarified. CYP4A plays an important role in pathophysiological process of myocardial abnormalities by modulating oxidative stress apoptosis (OS/Apop) signaling pathway. The present work aimed investigate whether mediates AGEs-induced injury. AGEs solution was administered intragastrically C57BL/6 mice for 60 days, while specific inhibitor CYP4A, HET0016,...
Abstract Hepatocellular carcinoma (HCC) ranks in the top of cancers leading to death. Early diagnosis is big challenge case HCC. Our vitro study showed that Ezrin expression lymphatic metastasis hepatocellular (LNM‐HCC) was associated with metastatic rate. Here we aim evaluate as diagnostic and/or prognostic biomarker LNM‐HCC mice. Chinese inbred 615 mice, Hca‐F and Hca‐P cell lines were used study. Histological changes determined by Hematoxylin Eosin, while assessed qRT‐PCR, western blot,...
Abstract A number of benzodioxane compounds were synthesized using the palladium‐catalyzed etherification aryl halides by employing triphenylphosphane ligands. This method was used as key step in synthesis two natural products isoamericanol and isoamericanin A.
Abstract The title podophyllotoxin analogues are evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549, and 95D.
Statement of Financial Accounting Standard (SFAS) No. 142 requires that goodwill and other intangible assets be tested annually for impairment. The estimation impairment is complex subject to management discretion errors. Motivated by the concern earnings errors, this study empirically examines impact SFAS on persistence, a measure accounting information quality. evidence suggests implementation provision under No.142 has an adverse effect accruals persistence. In addition, stock market...