A5100696304- Cancer Risks and Factors
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Magnolia and Illicium research
- Global Cancer Incidence and Screening
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Reproductive Biology and Fertility
- Pharmacological Effects of Natural Compounds
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Bone Tumor Diagnosis and Treatments
- Prostate Cancer Treatment and Research
- Signaling Pathways in Disease
- RNA Interference and Gene Delivery
- BRCA gene mutations in cancer
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Metabolism, Diabetes, and Cancer
- Myasthenia Gravis and Thymoma
- Nutritional Studies and Diet
- Phytoestrogen effects and research
- Surgical site infection prevention
- Musculoskeletal synovial abnormalities and treatments
Second Affiliated Hospital of Zhejiang University
2012-2024
Zhejiang University
2011-2021
Tianjin Medical University
2013
Tianjin Medical University Cancer Institute and Hospital
2012
Age is an important risk factor for breast cancer, but data regarding whether patient age at diagnosis related to cancer survival are conflicting. This population-based study evaluated the effect of on prognosis and identified outcome-related factors.We searched Surveillance, Epidemiology, End Results (SEER) database enrolled female primary non-metastatic cases. Patients were subdivided into seven groups, analyses associations between overall (OS) cancer-specific (BCSS) carried out using...
Objectives Disparities in the global burden of breast cancer have been identified. We aimed to investigate recent patterns and trends incidence associated mortality. also assessed cancer-related health inequalities according socioeconomic development factors. Design An observational study based on Global Burden Diseases. Methods Estimates mortality during 1990–2016 were obtained from Health Data Exchange database. Subsequently, data 2016 described using age-standardised age-specific...
MircroRNAs are emerging as critical regulators in carcinogenesis and chemoresistance multiple cancer types. In this study, we observed that the miR-944 level was upregulated breast patients' serum tumor tissues, suggesting is a promoter cancer. To investigate role of miR-944, performed gain- loss-of-function experiments vitro. We then demonstrated promotes cell proliferation metastasis lines. Furthermore, indicated associated with cisplatin resistance by targeting BNIP3. Knockdown specific...
MicroRNAs (miRNAs/miRs) are important regulators of multiple cellular processes, and their dysregulation is a common event in tumorigenesis, including the development hepatocellular carcinoma (HCC). Studies have shown that certain miRNAs associated with resistance to chemotherapy or drug sensitization; however, underlying mechanisms largely remained elusive. Multiple major barrier for treatment advanced HCC. In present study, miR-101 was observed be downregulated panel HCC cell lines,...
Many different treatments may affect the serum lipid profiles of breast cancer patients. This study analyzed levels at periods during treatment to observe changes in and after chemotherapy compare effects regimens on profiles. A total 805 patients were included this study. We measured who received surgery without prior operation 3, 6 12 months operation. In addition, underwent chemotherapy, last cycle chemotherapy. Lipid profile measurements cholesterol (TC), triglycerides (TG), low-density...
Adjuvant endocrine therapy improves the prognosis of early breast cancer with hormone receptor positivity. However, there is no systematic report on effect (particularly ovarian function suppression, OFS) serum lipids in premenopausal women. This retrospective cohort study aimed to determine whether various treatments had different effects blood lipids. enrolled 160 patients stage I-III eastern China. The initial diagnostic information was retrieved from patient's medical records, including...
Abstract Background Chemotherapy-induced amenorrhea (CIA) is one of the most frequent therapy-related adverse events observed in breast cancer patients who have undergone chemotherapy. Although characteristics CIA been studied Western countries, little known about Asian. We conducted a retrospective analysis to assess and influencing factors its association with menopause Chinese women underwent adjuvant chemotherapy for early-stage cancer. Methods Seventy-three premenopausal early stage...
Breast cancer is a worldwide threat to female health with patient outcomes varying widely. The exact correlation between global of breast and the national socioeconomic status still undetermined. Mortality-to-incidence ratio (MIR) was calculated contemporary age standardized incidence mortality rates for countries data available at GLOBOCAN 2012 database. MIR matched human development indexes (HDIs) system attainments were respectively obtained from Human Development Report World Health...
Circulating tumor cells (CTCs) in blood is the direct cause of metastasis. The isolation and detection CTCs whole very important clinical value early diagnosis, postoperative review, personalized treatment. It difficult to separate all types that efficiently rely on a single path due cancer cell heterogenicity. Here, we designed new kind "filter chip" for retention with high efficiency by integrating effects size specific antigens surface cells. filter chip consists semicircle arc arrays can...
Multidrug resistance (MDR) is a major challenge in cancer therapy. Apoptosis tolerance one of the key mechanisms MDR. Honokiol, small-molecule pharmacologically active component, exhibits competent cytotoxicity variety human cells through apoptosis and other forms programmed cell death (such as necrosis). Although much work has been done on its antitumor effects, little attention paid systemic evaluation efficacy honokiol combined with chemotherapeutic agents, especially drug‑resistant...
BACKGROUND: Carcinosarcoma is an exceptionally rare and poorly differentiated kind of breast neoplasm with only few published reports in the literature. CASE REPORT: We report a case carcinosarcoma 26-year-old Chinese female patient, presenting as multiple lumps single breast. A nipple-sparing modified radical mastectomy was performed. The patient now her 7th postoperative month disease-free. CONCLUSION: challenging to diagnose preoperatively, even core needle biopsy histopathology. Modified...
Aims Patients who have undergone prostate radiation are at increased risk for developing urothelial carcinoma. Radiation changes can cause significant cytological atypia in benign glands that may mimic pagetoid spread of GATA 3 is a common marker differentiating prostatic adenocarcinoma from The aim this study was to investigate the expression epithelium irradiated and malignant tissue. Methods results We performed retrospective review cases with atypia. staining on tissue without atypia, as...
Both chemotherapy-induced neutropenia (CIN) and febrile (FN) frequently occur can lead to dose-limiting toxicity even fatal chemotherapy side effects. The prophylactic use of recombinant human granulocyte colony-stimulating factor (rhG-CSF), including pegylated rhG-CSF (PEG-rhG-CSF), significantly reduces the risks CIN FN during in early-stage breast cancer (ESBC) patients. However, whether (G-CSF), especially PEG-rhG-CSF, influence white blood cell (WBC) counts absolute neutrophil (ANCs)...
Abstract Cardiovascular morbidity is closely associated with serum lipid level. We aimed to investigate the effects of different aromatase inhibitors, including letrozole, anastrozole, and exemestane, on profile eastern Chinese breast cancer patients. evaluated a retrospective cohort postmenopausal women early‐stage who received inhibitors. A total 116 without prior cardiovascular disease were included. Lipid changes at 3, 6, 12, 24 months compared across endocrine therapy categories. Our...
Abstract High-intensity focused ultrasound (HIFU) is playing an increasingly important role in cancer therapy. Primary synovial sarcomas of the chest wall are extremely rare. We report first case noninvasive HIFU therapy for control sarcoma. A 51-year-old man was diagnosed with spindle cell sarcoma on left through lumpectomy. After four cycles chemotherapy, local recurrence detected. Subsequent extended resection confirmed five a new chemotherapy option, relapsed again. Then patient received...
Honokiol is a pharmacologically active small molecule with multifunctional antitumor effects. Although plenty of literature available on honokiol-triggered apoptosis and programmed necrosis, few studies have investigated the potential existence death mode transition from to necrosis. In current study, we demonstrated that necrotic cell population (PI-positive) gradually increased early-stage apoptotic (PI-negative AV-positive) decreased in dose- time-dependent manner following honokiol...